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Archive for Pet Stem Cell Therapy

Gene Therapy Saves Puppies From A Fatal DiseaseAnd Maybe Us Next – Vocativ

For decades, some unluckydog lovers have welcomeda bundle of barking joy into their homes, only to see them perish from a mysterious disease mere weeks after their birth. The pups seemingly healthy muscles had literally wasted away in front of their owners eyes until they could no longer stand and breathe.

It wasnt until 2010 that a French research team isolated the genetic cause of this specific muscle-wasting disease in a group of Labrador Retrievers; these dogs were suffering from a single mutation that left them unable to produce an essential protein known asmyotubularin.Whats more, it was the exact kind of mutation and disease also long found in male human babies, too. That made the researchers wonder if these unfortunate puppiescould help us study the disease and even someday find a way to saveboth pets and people.

Now, years down the road, it appearsthey were right, thanks to a cutting-edgegene therapy treatment.

An international group of researchers, including some from the original French team, gathered together 10-week-old puppies with the mutation to take part in a randomized controlled trial. The dogs who were given a treatment that repaired their defectivemyotubularingene avoided the crippling muscle degeneration that killed the placebo-treated dogs by week 17. And by the ninth month of study, the saved puppies muscle and neurological function continued to match readings from healthy dogs, particularly forthose that got the highest doses.

The findings, building on an earlier proof-of-concept study of dogs and mice by the researchers, signal that a scaled-up treatment could save the lives of boys with the same sort of genetic flaw.

I believe that the dog study will be about as close as we will ever get to a human study, senior author Dr. Martin Childers of the University of Washington told Vocativ in an email. Because we found evidence that the gene therapy product spread throughout the entire skeletal musculature of adult dogs after a single infusion, it seems reasonable to expect a similar result in human patients.

Gene therapy has received plenty of attention for its potential to treat otherwise irreparable DNA defects, but according to the researchers, theres been little focus on bone- and muscle-relatedgenetic disorders. The condition treated in the current study, called x-linked myotubular myopathy, affects around one in every 50,000 boys, with most sufferers living no more than a few years. And though theres no true tally of how often it affects dogs, case reports of similar-sounding diseases have been published stretching back decades.

There will undoubtedly be hurdles to climb before the treatment Childers and his team developed, or a similar one, can be tested in people, Childers said. It is always possible that humans might respond differently, thus, clinical trials will be conducted with extraordinary care and oversight, he explained. And though the dogs suffered little adverse effects from the therapy delivered via a harmless virus researchers will still have to watch out for any possible toxicity in people.

That said, the treatment offers hope for both man and mutts. The changes seen after a single treatment have lasted for several years in the small sample of dogs the team has raised. So its possible that people wont need repeated doses or they would be infrequent, Childers said a big positive, given how expensive gene therapy is today.

And its also likely that these treatments, within the larger field of regenerative medicine, will find a place for dogs and other animals sooner than it will for people.

Veterinary medicine is ahead of human medicine in some cases with respect to regenerative technologies, Childers said. Stem cell infusions, for example, have been given to pets and horses for more than a decade.

But people may not have to wait so long for the promise of gene therapy either. Childers is hopeful that Audentes Therapeutics, a San Francisco biomedical company hes collaborating with (and which partially funded the current study), will begin their first human trials of a gene therapy treatment for x-linked myotubular myopathy, based on his teams research, later this year.

The teams findings were published earlier this February in Molecular Therapy.

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Gene Therapy Saves Puppies From A Fatal DiseaseAnd Maybe Us Next - Vocativ

Local vet taking part in stem cell therapy study for dogs – ABC Action News

TARPON SPRINGS, Fla. - Cosby just doesnt get around like he used to.

We have six dogs and hes always the one thats the last to get up. The last to get out, said his owner Brian Cirillo.

And for Cirillo, its sad to see.

I hate it. Its always like he always on his tippy topes on his back legs. So its heartbreaking.

But a new trial study that is about to start at the St. Francis Pet Care Center in Tarpon Springs, could be just what Cosby needs.

Veterinarian Mike Amsberry is offering stem cell therapy for dogs.

They are seeing that its very, very safe. And very effective.

This study is focused specifically on four-legged friends with arthritis.

But in the past hes seen stem cell treatments work wonders for other ailments.

Its cells treating the body, rather than then some foreign substance. Some medication.

In this trial, the stem cells come from umbilical cords of donor dogs.

Not only can qualified pets get the treatment for free, but owners are paid too.

Cosby seems like the perfect candidate.

I think thats where everything seems to be going with regard to medicine. So to be on the leading edge of that to potential help him without having to put him on a bunch of medicine is definitely a plus, said Cirillo.

The hope is one day Cosby will be able to keep up with the rest.

And lead the way to help thousands of other dogs.

For more information on the trial study go to petstemcells.org.

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Local vet taking part in stem cell therapy study for dogs - ABC Action News

Stem cell therapy adds pep to pets – Columbus Telegram

COLUMBUS For the past year, Dr. Todd Paczosa has been practicing what he calls the future of medicine.

The veterinarian treats his four-legged patients through stem cell therapy.

Im not anti-antibiotic, anti-medicine. I just believe that even in the future of cancer treatment that it is going to come down to your body healing itself, Paczosa said.

The process involves removing fatty tissue from a patient, extracting stem cells, then injecting the cells back into the animal's joints to promote healing.

Paczosa said he researched the treatment for about a decade before deciding to offer it at Redstone Veterinary Hospital in Columbus.

Our body is full of cells that heal. You get cut, your body heals. What we are doing is taking those cells, waking them up and saying, Hey, lets go to work, he said.

Since he started offering stem cell therapy last March, 17 dogs, horses and cattle have used the treatment. One of those patients is Butch, a 9-year-old schnauzer owned by Marge Biester of Columbus that was suffering from a strained ligament and achy joints.

He was really hurting. I had to do something for him, Biester said, adding that Butch wasnt putting much weight on his back leg when he walked.

The treatment was done in January. Butch was put under anesthesia to retrieve the fat tissue. Using equipment in-house, the stem cells were extracted and injected back into the dog that same day.

Paczosa, who has been a veterinarian for 23 years, said the entire process can be done in a day.

Biester noticed results in about two weeks.Butch wasnt doing his three-legged walk anymore and began acting like a more-active, younger version of himself.

Im amazed at how quickly he recovered, she said.

Paczosa said all of the animals he has treated so far have shown improvement.

One of these days, we will have one that doesnt work. Thats just medicine, but we havent had one yet, he said.

The possibility of the stem cell therapy not working can be a turnoff for some pet owners who might find it difficult to spend $1,900 to $2,400 for the treatment at Redstone. If it does work, Paczosa said the therapy is less expensive in the long run than putting an animal on medication for extended periods of time to ease the pain from arthritis.

Other pluses, he said, are that the regenerative therapy isnt as invasive as surgery and anti-rejection drugs don't have to be used since the cells come from the same animal.More than one joint can also be treated at a time and it can eliminate the use of non-steroidal anti-inflammatory drugs.

The biggest risks are putting the animal under anesthesia and infection of the surgical site where the fatty tissue is removed, typically from the shoulder area or abdomen.

Stem cell therapy is practiced at a few hundred veterinary clinics in the country. Redstone works with the animal stem cell company MediVet Biologics and uses that companys in-house technology.

Paczosa said owners have come from other states to use the therapy at his Columbus clinic.

Initial results from the procedure lasts about two years. An option to bank stem cells from a pet is available. A portion of what is taken can be stored in a lab and used again in the future.

For Paczosa's patients, results have been quick and ongoing.

Most owners have seen a dramatic improvement in two weeks. Our first patient is still seeing improvements, he said.

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Stem cell therapy adds pep to pets - Columbus Telegram

Stem cell transplant – Canadian Cancer Society

Stem cell transplant replaces a persons blood-forming (hematopoietic) stem cells. It is used when stem cells or the bone marrow has been damaged by chemotherapy drugs, radiation therapy or disease (such as cancer). The new stem cells make healthy blood cells.

Stem cells are young, immature cells. Stem cells mature (through a process called differentiation) to become different types of specialized cells. They can copy (replicate) themselves to replace or rebuild tissues in the body. Some stem cells mature into blood cells. Blood-forming stem cells develop into different types of blood cells in the bone marrow. When blood cells are mature, they move from the bone marrow into the bloodstream.

Stem cell transplants use blood-forming stem cells from the bone marrow and blood circulating in the body (peripheral blood) in adults. They may also use blood-forming stem cells from the umbilical cord (the cord that supplies a developing fetus with blood and nutrients). Sometimes a stem cell transplant may be described by the source of the stem cells. Stem cell transplant is also called:

There are 3 main types of stem cell transplants. They are described based on who donates the stem cells.

Both children and the family have questions and concerns about when stem cell transplant is done. Sometimes having a stem cell transplant can cause physical or psychological distress to children and their families. Being prepared and knowing what to expect can reduce anxiety for both children and parents. Parents can prepare children for and help them cope with a stem cell transplant by explaining what will happen in a way that the child will understand.

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Stem cell transplant - Canadian Cancer Society

Gene therapy tried in dogs with muscle disease could prove useful … – FierceBiotech

Theres a rare disorder that occurs when a gene mutation halts the production of myotubularina protein that facilitates normal muscle function. The disease, called myotubular myopathy (MTM), only affects males, and its ultimately fatal because it causes breathing difficulties.

Dogs get MTM, tooand that spelled opportunity for scientists at the University of Washington Medicine Institute for Stem Cell and Regenerative Medicine. In collaboration with five other academic institutions, they found a way to replace the faulty MTM gene with a functioning gene in dogs with the disease, they reported in the journal Molecular Therapy.

It worked: After a single infusion of genes, muscle strength was restored in the dogs, according to a press release. One year later, the dogs were indistinguishable from healthy animals, they said. "This regenerative technology allowed dogs that otherwise would have perished to complete restoration of normal health," said Dr. Martin K. "Casey" Childers, UW Medicine researcher and physician.

The researchers used a viral vector called adeno-associated virus serotype 8 (rAAV8) to deliver a healthy canine version of the MTM gene in dogs that were 10 weeks old and already showing symptoms. They believe a similar trial could be designed in people.

Gene therapy is under investigation for a wide range of disorders, though much of the progress to date has occurred outside the realm of muscular disorders. BioMarin Pharmaceutical, for example, is in mid-stage trials of a gene therapy treatment for hemophilia A. UniQure is working on several gene therapy products to treat diseases including Huntingtons and congestive heart failure. Its most advanced project, a gene therapy product to treat hemophilia B, received breakthrough designation status from the FDA in January.

One company that has achieved some success with gene therapy in inherited muscle disorders is AveXis, which is gearing up for a pivotal trial of its treatment for spinal muscular atrophy. AveXis won breakthrough therapy designation for its gene product last year, and high hopes for the product have prompted its stock to more than triple since the company went public early last year.

UW Medicine-led team that worked on the canine MTM trial observed that as they increased the dosage of genes, survival rates improved, they reported. They believe the study proves the potential utility of gene therapy in a wide range of diseases that are linked to mutated genes.

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Gene therapy tried in dogs with muscle disease could prove useful ... - FierceBiotech

The sheep that changed the world – The Economist (blog)

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The sheep that changed the world - The Economist (blog)

Hello, again, Dolly – The Economist

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Hello, again, Dolly - The Economist

Scientists are growing healthy skin for diseased patients – The Guam Daily Post (press release) (registration)

SAN JOSE, Calif. Small sheets of healthy skin are being grown from scratch at a Stanford University lab, proof that gene therapy can help heal a rare disease that causes great human suffering.

The precious skin represents growing hope for patients who suffer from the incurable blistering disease Epidermolysis bullosa and acceleration of the once-beleaguered field of gene therapy, which strives to cure disease by inserting missing genes into sick cells.

It is pink and healthy. Its tougher. It doesnt blister, said patient and research volunteer Monique Roeder, 33, of Cedar City, Utah, who has received grafts of corrected skin cells, each about the size of an iPhone 5, to cover wounds on her arms.

More than 10,000 human diseases are caused by a single gene defect, and Epidermolysis Bullosa is among the most devastating. Patients lack a critical protein that binds the layers of skin together. Without this protein, the skin tears apart, causing severe pain, infection, disfigurement and in many cases early death from an aggressive form of skin cancer.

Part of a pipeline of potential gene therapies

The corrected skin is part of a pipeline of potential gene therapies at Stanfords new Center for Definitive and Curative Medicine, announced last week.

The center, a new joint initiative of Stanford Healthcare, Stanford Childrens Health, and the Stanford School of Medicine, is designed to accelerate cellular therapies at the universitys state-of-the-art manufacturing facility in Palo Alto. Simultaneously, it is aiming to bring cures to patients faster than before and boost the financial value of Stanfords discoveries before theyre licensed out to biotech companies.

With trials such as these, we are entering a new era in medicine, said Dr. Lloyd B. Minor, Dean of the Stanford University School of Medicine.

Gene therapy was dealt a major setback in 1999 when Jesse Gelsinger, an Arizona teenager with a genetic liver disease, had a fatal reaction to the virus that scientists had used to insert a corrective gene.

But current trials are safer, more precise and build on better basic understanding. Stanford is also using gene therapy to target other diseases, such as sickle cell anemia and beta thalassemia, a blood disorder that reduces the production of hemoglobin.

There are several diseases that are miserable and worthy of gene therapy approaches, said associate professor of dermatology Dr. Jean Tang, who co-led the trial with Dr. Peter Marinkovich. But Epidermolysis Bullosa, she said, is one of the worst of the worst.

'Makes you feel like youre making a difference in the world'

It took nearly 20 years for Stanford researchers to bring this gene therapy to Roeder and her fellow patients.

It is very satisfying to be able to finally give patients something that can help them, said Marinkovich. In some cases, wounds that had not healed for five years were successfully healed with the gene therapy.

Before, he noted, there was only limited amounts of what you can do for them. We can treat their wounds and give them sophisticated Band-Aids. But after you give them all that stuff, you still see the skin falling apart, Marinkovich said. This makes you feel like youre making a difference in the world.

Roeder seemed healthy at birth. But when her family celebrated her arrival by imprinting her tiny feet on a keepsake birth certificate, she blistered. They encouraged her to lead a normal childhood, riding bicycles and gentle horses. Shes happily married. But shes grown cautious, focusing on photography, writing a blog and enjoying her pets.

Scarring has caused her hands and toes to become mittened, or webbed. Due to pain and risk of injury, she uses a wheelchair rather than walking long distances.

Every movement has to be planned out in my head so I dont upset my skin somehow, she said. Wound care can take three to six hours a day.

Doctor's infect patient's skin with missing gene

The team of Stanford experts harvested a small sample of skin cells, about the size of a pencil eraser, from her back. They put her cells in warm broth in a petri dish, where they thrived.

To this broth they added a special virus, carrying the missing gene. Once infected, the cells began producing normal collagen.

They coaxed these genetically corrected cells to form sheets of skin. The sheets were then surgically grafted onto a patients chronic or new wounds in six locations. The team reported their initial results in Novembers Journal of the American Medical Association.

Stem cell biology, genome editing and tissue engineering work together

Historically, medical treatment has had limited options: excising a sick organ or giving medicine, said Dr. Anthony E. Oro of Stanfords Institute for Stem Cell Biology and Regenerative Medicine. When those two arent possible, theres only symptom relief.

But the deciphering of the human genome, and new tools in gene repair, have changed the therapeutic landscape.

Now that we know the genetic basis of disease, we can use the confluence of stem cell biology, genome editing and tissue engineering to develop therapies, Oro said.

Its not practical to wrap the entire body of a patient with Epidermolysis Bullosa in vast sheets of new skin, like a mummy, Oro said.

But now that the team has proven that gene therapy works, they can try related approaches, such as using gene-editing tools directly on the patients skin, or applying corrected cells like a spray-on tan.

A cure doesnt take one step, said Tang. It takes many steps towards disease modification, and this is the first big one. Were always looking for something better.

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Scientists are growing healthy skin for diseased patients - The Guam Daily Post (press release) (registration)

Lyme disease mum releases video of herself doubling-over in agony to warn others of tick infection – The Sun

A MUM who is desperately fighting a serious bacterial infection after being bitten by a TICK has released harrowing footage of herself screaming in pain to raise awareness of Lyme disease.

Heidi Luckraft, from Beeston, Nottinghamshire, was walking her dog four years ago when she was bitten but it wasnt until last year that she was finally diagnosed with Lyme disease.

YouTube

YouTube

The horrific clip sees the 34-year-old hunched over on the floor as she howls in pain, while tears stream down her face, smudging her eye makeup.

Speaking to the Daily Mirror, the mum-of-two said:I really want to help others as it left me fighting for my life in hospital. It could have been prevented by an early diagnosis.

It isnt the NHSs fault. Its overstretched, underfunded and they need more trained doctors and urgent funding from the government.

Its no life having to live with Lyme disease and I just wish others suffering would be able to get treatment and diagnosis sooner.

SWNS:South West News Service

Heidi claims she was misdiagnosed with various illnesses including meningitis and chronic fatigue syndrome before a tell-tale rash emerged which identified her symptoms as Lyme disease.

Her friend Jodie Deegan, 34, and Heidis husband, Mark, set up a fundraising page to raise cash for treatment in the US which isnt currently available in the UK last year.

After raising 17,000 and remortgaging her house, she had Infusion treatment at a clinic in Germany.

This works by restoring the immune function, ridding the body of harmful parasites.

SWNS:South West News Service

Shes since stopped having seizures and shakes, and has managed to reduce pain medication by a whopping 70 per cent.

Shes now calling for better and more accurate blood testing for Lyme disease, as roughly only 30 per cent of cases in the UK are diagnosed correctly.

The National Institute of Health and Care Excellence is set to devise guidelines setting out the care people diagnosed with Lyme disease should receive in 2018.

Speaking last year, Jodie, who lives in Stockport, described her friends condition: She needs IV infusions, immune boosting IV therapies, stem cell treatments alongside IV antibiotics.

There are no UK trained NHS Lyme doctors here, we need her to be treated in the States and her bloods need to be tested in Germany.

Caters News Agency

SWNS:South West News Service

Shes always done so much for charity and helped kids with cancer.

Shell go to an event, dressed up as Elsa and sing for the children, then collapse in her wheelchair and cry from all the pain when shes finished.

She puts on a brave face, but what shes going through is really serious.

Heidi was walking her dog in Wollaton Park, Nottinghamshire, in 2012 when she was bitten by an infected tick.

She immediately felt tired and unwell, but a series of misdiagnosed illnesses meant that by the time she was diagnosed with Lyme disease in 2015, doctors couldnt do anything to treat it.

Jodie speaking on behalf of Heidi because she was too unwell said: Last week she had to be resuscitated three times.

She says her brain feels like its swelling and she gets really bad migraines.

All she can do is sit in a dark room and not even look at her phone.

At first she would have more good days than bad days, but now were thankful if she gets a good hour.

Shes just in agony.

Lyme disease is a bacterial infection It is spread by infected ticks who feed on human blood Many sufferers develop a distinctive red circular rash with a ring around it Early signs include flu-like symptoms, such as tiredness and muscle pain If diagnosed early, it can be treated with antibiotics

Heidi, mum to Ocian, 16, and Rhianna, 13, was forced to hide from the world after keeping her illness secret for so long.

Jodie added: She never really told anyone about it, she just got on with it.

Now her phone is going mad with people getting in touch.

When I told her wed already raised 800 she burst into tears.

She keeps asking do you think well do it?, but I know she doesnt want to get her hopes up just in case.

The musical theatre performer said: Her and Mark have been together for 20 years.

Its the love of his life and theyve got two gorgeous girls, its just heartbreaking.

SWNS:South West News Service

"I met Heidi when I was 14 and in a children's home.She took me under her wing and she's been like a big sister ever since.

"When she showed me that video and I saw how much pain she was in, I just knew we had to do something.

"She always puts other people first, it's time she did something for herself."

Lyme disease is spread via infected ticks which are found in woodland.

Cases are on the rise: in 2003, there were 346 reported cases which rose to 1,000 in 2015.

And the disease has become more well-known after it was revealed model Bella Hadid, her mum Yolanda and brother Anwar all suffer from the illness.

A number of celebs have also contracted Lyme disease

- Model Bella Hadid has been open about her battle with Lyme disease - The star's mum, Yolanda Hadid, and her brother Anwar also suffer - Singer Avril Lavigne was diagnosed with the condition in 2014 - Actor Alex Baldwin found out he had Lyme in 2011

If caught early enough, Lyme disease is treated with a course of antibiotics.

Jodie said: "If she was correctly diagnosed within 48 hours, all she would have needed is a two week course of antibiotics.

"When she was finally diagnosed it was bittersweet.

"She was relieved to have a diagnosis but by that time, it was so serious.

"But she's such a positive person.

"She keeps saying she's been given the disease so she can help other people in the future."

We pay for your stories! Do you have a story for The Sun Online news team? Email us at tips@the-sun.co.uk or call 0207 782 4368.

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Lyme disease mum releases video of herself doubling-over in agony to warn others of tick infection - The Sun

Teams of Top Scientists to Join University of Maryland School of Medicine as Major Recruitment Initiative Has Strong … – PR Newswire (press release)

The new teams of scientists will bring federal funding of nearly $30 million (more than $11 million annually) in total grants and contracts to the UM SOM, which surpassed $400M in total research funding in 2016.

Many of the new scientists will be housed in the new 450K sq ft state-of-the art research facility on West Baltimore St., costing more than $300M, and which is scheduled to be completed before the end of 2017.The new SOM Research Building will feature among the most advanced laboratories and medical research technology found anywhere. Dean Reece pointed out that the new building is a major asset to the School's research portfolio and will be most appealing to leading scientists who wish to have a state-of-the-art research facility for conducting discovery-based medicine in a collaborative manner and at a very high level of sophistication.

"We are off to a tremendous start with the STRAP Initiative, and are very excited to be able to attract these firstteams of outstanding individuals who are nationally- and internationally recognized in their respective fields," said Dean Reece, who is also Vice President for Medical Affairs, University of Maryland and the John Z. and Akiko K. Bowers Distinguished Professor."The University of Maryland School of Medicine is being recognized as a magnet institution for individuals interested in pursuing possible cures and treatments for the most critical and complex diseases that we face around the world."

The program is the most significant and ambitious effort to recruit scientists in the School's 210-year old history. It signifies an aggressive move by the UM SOM to advance in the top most echelon of leading biomedical research institutions in the nation. In particular, the School is targeting top researchers and physician scientists who will help to accelerate breakthrough discoveries in critical areas, including brain disorders, cancer, and cardiovascular-metabolic diseases. The initiative will lead to rich, collaborative research programs across the School of Medicine, the Campus and the University System, Dean Reece noted.

Experts in Lung Injury

Stephen N. Davis MBBS, the Dr. Theodore E. Woodward Professor and Chair of the Department of Medicine; Jeffrey D. Hasday, MD, the Dr. Herbert Berger Endowed Professor of Medicine and Division Head, Pulmonary & Critical Care Medicine; and Peter Rock, MD, MBA, the Dr. Martin A. Helrich Professor and Chair of Anesthesiology; with collaboration from Thomas M. Scalea, MD, the Francis X. Kelly Professor in Trauma Surgery, Director of the Program in Trauma and Physician-in-Chief at the University of Maryland R Adams Cowley Shock Trauma Center; and Scott M. Thompson, PhD, Professor and Chair, Department of Physiology, announced the addition of two top pulmonary scientists:

Konstantin Birukov, MD, PhD, comes to UM SOM from the University of Chicago School of Medicine, where he was an Associate Professor of Medicine in the Section of Pulmonary and Critical Care. He is a leading expert on the molecular mechanisms regulating lung vascular permeability, the role of mechanical forces and oxidized phospholipidome in development and recovery of lung function, and innovative strategies to prevent acute lung injury. Prior to the University of Chicago, he was a research associate at the Johns Hopkins University School of Medicine. He has authored or co-authored more than 120 peer-reviewed papers and reviews, as well as two book chapters, and has four patents. Dr. Birukov will have his primary appointment in the UM SOM Department of Anesthesiology, and a secondary appointment in the Department of Medicine, and serve as Director of the University of Maryland School of Medicine Lung Biology Research Program.

Anna Birukova, MD, is a widely-published investigator in several areas, including the regulation of lung vascular permeabilityand inflammation by microtubules, microtubule-associated signaling molecules, and new ways to protect the lungs from acute injury. Prior to coming to UM SOM, she was also an Associate Professor of Medicine in theSection for Pulmonary and Critical Care at the University of Chicago. Prior to that, she was a research associate at Johns Hopkins University School of Medicine. Shehas authored or co-authored more than 100 peer-reviewed papers and reviews and has written three book chapters. Dr. Birukova will have her primary appointment in the UM SOM Department of Medicine and a secondary appointment in the Department of Anesthesiology, and serve as Associate Director of the University of Maryland School of Medicine Lung Biology Research Program.

The team comes to the UM SOM with $4.35 million in total research funding from the National Institutes of Health (NIH), (more than $2 million annually).

Top Investigators in Muscle and Tendon Formation

In the Department of Orthopaedics, Andrew N. Pollak, MD, the James Lawrence Kernan Professor and Chair, has led the effort to recruit a team of leading orthopaedics researchers:

Masahiro Iwamoto, DDS, PhD, is an acclaimed scientist who has focused on the development of articular cartilage, the regulation of bone growth, and the repair of muscle, cartilage and other connective tissue. Prior to coming to UM SOM, he was a Research Associate Professor of Orthopaedic Surgery at the University of Pennsylvania School of Medicine. Prior to that, he was an Associate Professor of Orthopaedic Surgery at Thomas Jefferson University in Philadelphia. Dr. Iwamoto has earned four patents, and has authored or co-authored more than 90 peer-reviewed papers.

Motomi Enomoto-Iwamoto, DDS, PhD, comes from the Children's Hospital of Philadelphia (CHOP), where she was a Research Associate Professor in Orthopaedic Surgery.She is an accomplished investigator who studies the cellular and signaling mechanisms that regulate skeletal development and function; the cellular pathways that lead to cartilage tumors and osteoarthritis; and the role of local progenitor cells in articular cartilage and tendon repair. Prior to CHOP, she was an Associate Professor of Orthopaedic Surgery at Thomas Jefferson University. Dr. Iwamoto has earned four patents, and has authored or co-authored more than 70 peer-reviewed papers.

The team joins the UM SOM faculty with more than $2.7 million in total research funding from the NIH ($675K annually).

Leading Neuroscientist in Brain Development

In the Department of Pharmacology, Margaret M. McCarthy, PhD, Professor and Chair, and Bankole A.Johnson, DSc, MD, MB, ChB, MPhil, the Dr. Irving J. Taylor Professor and Chair, Department of Psychiatry, have announced the addition of a nationally-recognized neuroscientist:

Tracy L. Bale, PhD, is a leading expert on the links between stress and subsequent risk for neurodevelopmental disorders including autism and schizophrenia in offspring. Her innovative studies usemoleculartechniques to determine the mechanisms by which this may occur. Her studies ontheplacenta have revealed novel sex differences that may predict increased prenatal risk for disease in males.Prior to coming to UM SOM, she was a Professor of Neuroscience at the University of Pennsylvania School of Medicine, andtheSchool of Veterinary Medicine. She is the Co-Director of the Specialized Center for Research on Women's Health and Penn PROMOTES, and the Scientific Director for the BIRCWH K12. She serves as Chair of NIH study section, is a Reviewing Editor for the Journal of Neuroscience, and serves on the Congressional Committee on Gulf War Veterans Health.She has authored or co-authored more than 90 peer-reviewed papers.

Dr. Bale brings nearly $4.5 million in totalresearch funding from the NIH, ($1.9 million annually).

Top Team in Imaging and Spectroscopy

In the Department of Diagnostic Radiology & Nuclear Medicine, Elias Melhem, MD, the Dean John M. Dennis Chair in Radiology, has announced a team of top investigators from Hawaii.

Linda Chang, MD, MS, FAAN, FANA, is a highly-acclaimed physician-scientist coming to the UM SOM from the University of Hawaii, where she was a Professor of Medicine at the John A. Burns School of Medicine in Honolulu, as well as director of the school's Neuroscience and Magnetic Resonance Research Program. After graduating with an MD degree from Georgetown University, she became an Assistant Professor, and then an Associate, Professor of Neurology at the UCLA School of Medicine in Los Angeles. Dr. Chang has done research on a range of topics, including how methamphetamine and other drugs affect the brain and cognition, the neurological effects of HIV/AIDS and how the aging affects the brain. Over her career, she has authored or co-authored 200 peer-reviewed papers, and has written nearly 30 book chapters and monographs. She has also delivered 175 lectures, grand rounds, workshops & symposia.

Thomas Ernst, PhD, was also a Professor of Medicine at the John A. Burns School of Medicine at the University of Hawaii. Dr. Ernst earned a PhD degree in physics from the University of Freiburg in Germany. He has focused on several areas of research, including the development of strategies to minimize motion sensitivity of magnetic resonance and other imaging techniques, and to improve the overall precision of these techniques; the use of imaging to study HIV-related brain disease, the neurotoxic effects of methamphetamine and other illicit drugs and overall brain development. He has authored or co-authored more than 200 peer-reviewed papers, more than 10 book chapters, and has given dozens of lectures and seminars.

The team brings $9.2 million in total research funding from the NIH, (nearly $3 million annually).

Leader in Bioengineering and Artifical Organs

In the Department of Surgery, Stephen T. Bartlett, MD, the Peter Angelos Distinguished Professor and Chair in Surgery, and Bartley Griffith, MD, the Thomas E. and Alice Marie Hales Distinguished Professor in Transplant Surgery, announced that a top bioengineering scientist is returning to the UM SOM faculty.

Zhongjun Jon Wu, PhD, is an internationally recognized authority on the development of artificial organs, ventricular assist devices, blood pumps, artificial lungs and respiratory assist devices. He was an Assistant and Associate Professor at UM SOM from 2003 to 2014, when he became a Professor of Cardiovascular and Thoracic Surgery at the University of Louisville School of Medicine. His primary areas of research are in blood flow, flow visualization, blood damage, cell mechanics, cardiac biomechanics, hemodynamics; biological responses to artificial organs in human and animals; and stem cell therapies for heart and lung diseases. He has earned or applied for 10 patents, has authored or co-authored more than 90 peer-reviewed papers.

Dr. Wu brings nearly $1.6 million in total research funding from the NIH, (more than $660K annually)

Academic Leader in Physical Therapy

In the Department of Physical Therapy and Rehabilitation Science, Mark Rogers, PhD, PT, Professor and Chair, Department of Physical Therapy and Rehabilitation Science, along with Department of Orthopaedics Chair Andrew Pollak, MD, announced the addition of top research scientist in physical medicine and rehabilitation science.

Li-Qun Zhang, PhD, is a Senior Research Scientist who joins the SOM faculty as Professor in the Department of Physical Therapy & Rehabilitation Science (PTRS), with a secondary appointment in the Department of Orthopaedics.Dr. Zhang was previously a Professor in the Departments of Physical Medicine & Rehabilitation, Orthopaedic Surgery and Biomedical Engineering at Northwestern University.He also served as Director of Ortho Biomech Research at Northshore University Health System and Senior Research Scientist at the Rehabilitation Institute of Chicago. He is widely published and speaks internationally on his research related to biomechanics and biomedical engineering.

Throughout his research career, he has consistently received annual NIH funding and currently holds $2.7 million total in grants ($833K annually) from the National Institute of Disability and Rehabilitation Research.

University of Maryland School of Medicine is a Major Global Research Enterprise

With more than $400M in total extramural research funding last year, the School of Medicine now ranks among the top research intensive institutions nationally.Key advances since the UM SOM celebrated its bicentennial in 2007 include:

About the University of Maryland School of Medicine

Celebrating its 210th Anniversary, the University of Maryland School of Medicine was chartered in 1807 as the first public medical school in the United States. It continues today as a global leader in accelerating innovation and discovery in medicine. The School of Medicine is the founding school of the University of Maryland and is an integral part of the 11-campus University System of Maryland. Located on the University of Maryland's Baltimore campus, the School of Medicine works closely with the University of Maryland Medical Center and Medical System to provide a research-intensive, academic and clinically based education. With 43 academic departments, centers and institutes and a faculty of more than 3,000 physicians and research scientists plus more than $400 million in extramural funding, the School is regarded as one of the leading biomedical research institutions in the U.S. with top-tier faculty and programs in cancer, brain science, surgery and transplantation, trauma and emergency medicine, vaccine development and human genomics, among other centers of excellence. The School is not only concerned with the health of the citizens of Maryland and the nation, but also has a global presence, with research and treatment facilities in more than 35 countries around the world.http://medschool.umaryland.edu/

Media Contact: David Kohn dkohn@som.umaryland.edu 410-706-7590

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