Glioblastoma (GBM) is a fast-growing type of central nervous system tumour that forms from glial (supportive) tissue of the brain and spinal cord, with cells that look very different from normal ones, said Dr Ata Ul Aleem Bhatti, ex-instructor neurosurgeon, Aga Khan University Medical College, Dar as Salaam, Tanzania, and consultant neurosurgeon at the South City Hospital, Karachi.

Addressing a public awareness seminar on World GBM Day 2022 in collaboration with the Neurospinal & Cancer Care Postgraduate Institute, he said: Like most brain tumors, GBM grow more rapidly than their benign counterparts and affect the brain in many different ways depending on the part of the brain they are located.

Dr Bhatti further explained: Unfortunately, like most cancers in other parts of the body, the exact cause of GBM is unknown. Glioblastoma itself is not the only form of brain cancer, though it is the most common and most aggressive type. Other malignant brain tumours include medulloblastomas, lymphomas and anaplastic astrocytomas, to mention a few.

Various risk factors linked to developing cancer in the brain include over exposure to radiation and some rare inherited conditions. In all of these cases, the exact connection or link remains a mystery, but we do see a pattern of occurrence.

Again, unfortunately, there are no symptoms that will immediately tell someone they are developing a malignant brain tumour, however, there are some common things to look out for, when a person develops a mass or growth in the brain, either benign or malignant. These include a bad headache, but not the type one gets after spending hours in Karachi traffic or a stressful day. This headache is usually worse in the morning and persistent over several weeks. It may be associated with a feeling of wanting to vomit (nausea) or actually vomiting, which tends to make the person feel better.

Unfortunately, according to Dr Bhatti, at the moment there is no cure for brain cancers. While there are many therapies that are being tried and a lot of experimental work going on, we are yet to find a cure.

Malignant brain tumours are usually treated with a combination of surgery, radiotherapy and chemotherapy.

Sometimes, newer options like hormone therapy, immune therapy and others are also used. Which option is offered depends on the type of cancer involved. Surgery remains a main part of any treatment regime for GBM, since it allows for accurate diagnosis and also reduces the amount of tumour the body has to fight against.

In some cases, an attempt is made to remove as much of the tumour as possible to allow the radiotherapy and chemotherapy be more effective.

Dr Adeel Ahmed Memon, consultant clinical & radiation oncologist and assistant professor at the Karachi Institute of Radiotherapy & Nuclear Medicine (KIRAN), gave a radiation oncologist perspective for GBM.

Radiosurgery is a treatment method that uses specialized radiation delivery systems to focus radiation at the site of the tumor, while minimizing the radiation dose to the surrounding brain. Radiosurgery may be used in selective cases for tumor recurrence, often using additional information derived from MRS or PET scans, he said.

Studies have shown that radiation therapy provides most patients with improved outcomes and longer survival rates when given the combination of surgery, radiation and chemotherapy compared with surgery alone. Radiation also may be used as the sole treatment when a glioblastoma tumor is in an area that is not appropriate for surgery.

Guest speaker Dr Reena Kumari, consultant medical oncologist & assistant professor at Dr Ziauddin University Hospital, also shared her views regarding the role of chemotherapy, targeted & immunotherapy and discussed why GBM was difficult to treat brain tumor.

When treating GBM, she explained, what makes treatment challenging is that you have tumor cells that are not active, meaning they are dormant. These cells are known as cancer stem cells and since they are not active they do not die by radiation and chemotherapy.

Unlike other cancers such as breast or lung, brain tumors are extremely genetically heterogeneous means there is a high degree of variation within the same tumor cells that makes each individual glioblastoma molecularly distinct. This can be challenging when predicting prognosis and treatment, if it is in an area which is difficult access, or too close to major blood vessels or other important centers of the brain, it can make surgery tough, tendency of the tumor to come back aggressively is also a great challenge.

A promising targeted treatment is the anti-vascular endothelial growth factor (VEGF) monoclonal antibody bevacizumab. It has been approved by FDA for several different types of cancer, including. Angiogenesis is a key survival feature of many cancers as tumors rely on nutrients from the vasculature to proliferate

A clinical trial has found that selinexor, the first of a new class of anti-cancer drugs called selective inhibitors of nuclear export (SINE) , is able to shrink tumors in almost a third of patients with recurrent glioblastoma,

Dr Kumari urged people to be careful, saying: Negligence in treatment of diseases like GBM can be fatal. She further said that timely treatment of brain tumor was very important as chances of relapsing increases with the grade of tumor.

Dr Sadia Afsar, in-Charge, Neurosurgery Department, Abbasi Shaheed Hospital , highlighted the problems faced by patients with GBM and other brain tumors as this is ignored by community.

Government needs to realise that these conditions are quite common and provide more facilities for early diagnosis and treatment of GBM & other types of brain tumors like MRI, CT-Scan & PET-CT Scanner must be readily available across the country to enhance diagnosis.

The scarcity of Radiotherapy modalities in the country has already been highlighted by her and said that a huge time is wasted in long queue, additionally. The teaching hospitals need to also be equipped to perform proper neurosurgery department and OT, as this is the first step in any treatment programme for brain tumors, including GMBs.

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Negligence in treatment of diseases like glioblastoma can be fatal, seminar told - The News International

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Wilmington, Delaware, United States, Transparency Market Research Inc.: Stem cells are bodys raw materials or cells from which all other cells with specialized functions are generated. These cells can be guided to become specific cells that regenerate and repair diseased or damaged tissues in patients suffering from various diseases.

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This stem cell therapy is called regenerative medicine or regenerative therapy to treat several diseases. Stem cell and regenerative therapy promotes the repair response of diseased, injured, or dysfunctional tissue using stem cells or derivatives of stem cells.

Stem cell therapies can be used to treat patients with Parkinson's disease, amyotrophic lateral sclerosis, diabetes type 1, Alzheimer's disease, heart disease, stroke, burns, cancer, and osteoarthritis

In advanced therapies, stem cells are used to replace damaged cells and serve as a replacement method for the donor's immune system to fight several types of blood-related diseases and cancer

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Key Drivers and Restraints of Global Stem Cell and Regenerative Therapy Market

Unclear Regulatory Guidelines Hampers Global Market

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Cell Therapy Segment to Dominate Global Market

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Hospitals to be Major End-user Segment

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North America to Lead Global Stem Cell and Regenerative Therapy Market

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Key manufacturers operating in the global market are:

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In molecular biologist David Sinclair's lab at Harvard Medical School, old mice are growing young again.

Using proteins that can turn an adult cell into a stem cell, Sinclair and his team have reset aging cells in mice to earlier versions of themselves. In his team's first breakthrough, published in late 2020, old mice with poor eyesight and damaged retinas could suddenly see again, with vision that at times rivaled their offspring's.

"It's a permanent reset, as far as we can tell, and we think it may be a universal process that could be applied across the body to reset our age," said Sinclair, who has spent the last 20 years studying ways to reverse the ravages of time.

"If we reverse aging, these diseases should not happen. We have the technology today to be able to go into your hundreds without worrying about getting cancer in your 70s, heart disease in your 80s and Alzheimer's in your 90s." Sinclair told an audience at Life Itself, a health and wellness event presented in partnership with CNN.

"This is the world that is coming. It's literally a question of when and for most of us, it's going to happen in our lifetimes," Sinclair told the audience.

"His research shows you can change aging to make lives younger for longer. Now he wants to change the world and make aging a disease," said Whitney Casey, an investor who is partnering with Sinclair to create a do-it-yourself biological age test.

While modern medicine addresses sickness, it doesn't address the underlying cause, "which for most diseases, is aging itself," Sinclair said. "We know that when we reverse the age of an organ like the brain in a mouse, the diseases of aging then go away. Memory comes back; there is no more dementia.

"I believe that in the future, delaying and reversing aging will be the best way to treat the diseases that plague most of us."

A reset button

In Sinclair's lab, two mice sit side by side. One is the picture of youth, the other gray and feeble. Yet they are brother and sister, born from the same litter -- only one has been genetically altered to age faster.

If that could be done, Sinclair asked his team, could the reverse be accomplished as well? Japanese biomedical researcher Dr. Shinya Yamanaka had already reprogrammed human adult skin cells to behave like embryonic or pluripotent stem cells, capable of developing into any cell in the body. The 2007 discovery won the scientist a Nobel Prize, and his "induced pluripotent stem cells," soon became known as "Yamanaka factors."

However, adult cells fully switched back to stem cells via Yamanaka factors lose their identity. They forget they are blood, heart and skin cells, making them perfect for rebirth as "cell du jour," but lousy at rejuvenation. You don't want Brad Pitt in "The Curious Case of Benjamin Button" to become a baby all at once; you want him to age backward while still remembering who he is.

Labs around the world jumped on the problem. A study published in 2016 by researchers at the Salk Institute for Biological Studies in La Jolla, California, showed signs of aging could be expunged in genetically aged mice, exposed for a short time to four main Yamanaka factors, without erasing the cells' identity.

But there was a downside in all this research: In certain situations, the altered mice developed cancerous tumors.

Looking for a safer alternative, Sinclair lab geneticist Yuancheng Lu chose three of the four factors and genetically added them to a harmless virus. The virus was designed to deliver the rejuvenating Yamanaka factors to damaged retinal ganglion cells at the back of an aged mouse's eye. After injecting the virus into the eye, the pluripotent genes were then switched on by feeding the mouse an antibiotic.

"The antibiotic is just a tool. It could be any chemical really, just a way to be sure the three genes are switched on," Sinclair said. "Normally they are only on in very young developing embryos and then turn off as we age."

Amazingly, damaged neurons in the eyes of mice injected with the three cells rejuvenated, even growing new axons, or projections from the eye into the brain. Since that original study, Sinclair said his lab has reversed aging in the muscles and brains of mice and is now working on rejuvenating a mouse's entire body.

"Somehow the cells know the body can reset itself, and they still know which genes should be on when they were young," Sinclair said. "We think we're tapping into an ancient regeneration system that some animals use -- when you cut the limb off a salamander, it regrows the limb. The tail of a fish will grow back; a finger of a mouse will grow back."

That discovery indicates there is a "backup copy" of youthfulness information stored in the body, he added.

"I call it the information theory of aging," he said. "It's a loss of information that drives aging cells to forget how to function, to forget what type of cell they are. And now we can tap into a reset switch that restores the cell's ability to read the genome correctly again, as if it was young."

While the changes have lasted for months in mice, renewed cells don't freeze in time and never age (like, say, vampires or superheroes), Sinclair said. "It's as permanent as aging is. It's a reset, and then we see the mice age out again, so then we just repeat the process.

"We believe we have found the master control switch, a way to rewind the clock," he added. "The body will then wake up, remember how to behave, remember how to regenerate and will be young again, even if you're already old and have an illness."

Science already knows how to slow human aging

Studies on whether the genetic intervention that revitalized mice will do the same for people are in early stages, Sinclair said. It will be years before human trials are finished, analyzed and, if safe and successful, scaled to the mass needed for a federal stamp of approval.

While we wait for science to determine if we too can reset our genes, there are many other ways to slow the aging process and reset our biological clocks, Sinclair said.

"The top tips are simply: Focus on plants for food, eat less often, get sufficient sleep, lose your breath for 10 minutes three times a week by exercising to maintain your muscle mass, don't sweat the small stuff and have a good social group," Sinclair said.

What controls the epigenome? Human behavior and one's environment play a key role. Let's say you were born with a genetic predisposition for heart disease and diabetes. But because you exercised, ate a plant-focused diet, slept well and managed your stress during most of your life, it's possible those genes would never be activated. That, experts say, is how we can take some of our genetic fate into our own hands.

Cutting back on food -- without inducing malnutrition -- has been a scientifically known way to lengthen life for nearly a century. Studies on worms, crabs, snails, fruit flies and rodents have found restricting calories "delay the onset of age-related disorders" such as cancer, heart disease and diabetes, according to the National Institute on Aging. Some studies have also found extensions in life span: In a 1986 study, mice fed only a third of a typical day's calories lived to 53 months -- a mouse kept as a pet may live to about 24 months.

Studies in people, however, have been less enlightening, partly because many have focused on weight loss instead of longevity. For Sinclair, however, cutting back on meals was a significant factor in resetting his personal clock: Recent tests show he has a biological age of 42 in a body born 53 years ago.

"I've been doing a biological test for 10 years now, and I've been getting steadily younger for the last decade," Sinclair said. "The biggest change in my biological clock occurred when I ate less often -- I only eat one meal a day now. That made the biggest difference to my biochemistry."

Additional ways to turn back the clock

Sinclair incorporates other tools into his life, based on research from his lab and others. In his book "Lifespan: Why We Age and Why We Don't Have To," he writes that little of what he does has undergone the sort of "rigorous long-term clinical testing" needed to have a "complete understanding of the wide range of potential outcomes." In fact, he added, "I have no idea if this is even the right thing for me to be doing."

With that caveat, Sinclair is willing to share his tips: He keeps his starches and sugars to a minimum and gave up desserts at age 40 (although he does admit to stealing a taste on occasion). He eats a good amount of plants, avoids eating other mammals and keeps his body weight at the low end of optimal.

He exercises by taking a lot of steps each day, walks upstairs instead of taking an elevator and visits the gym with his son to lift weights and jog before taking a sauna and a dip in an ice-cold pool. "I've got my 20-year-old body back," he said with a smile.

Speaking of cold, science has long thought lower temperatures increased longevity in many species, but whether it is true or not may come down to one's genome, according to a 2018 study. Regardless, it appears cold can increase brown fat in humans, which is the type of fat bears use to stay warm during hibernation. Brown fat has been shown to improve metabolism and combat obesity.

Sinclair takes vitamins D and K2 and baby aspirin daily, along with supplements that have shown promise in extending longevity in yeast, mice and human cells in test tubes.

One supplement he takes after discovering its benefits is 1 gram of resveratrol, the antioxidant-like substance found in the skin of grapes, blueberries, raspberries, mulberries and peanuts.

He also takes 1 gram of metformin, a staple in the arsenal of drugs used to lower blood sugars in people with diabetes. He added it after studies showed it might reduce inflammation, oxidative damage and cellular senescence, in which cells are damaged but refuse to die, remaining in the body as a type of malfunctioning "zombie cell."

However, some scientists quibble about the use of metformin, pointing to rare cases of lactic acid buildup and a lack of knowledge on how it functions in the body.

Sinclair also takes 1 gram of NMN, or nicotinamide mononucleotide, which in the body turns into NAD+, or nicotinamide adenine dinucleotide. A coenzyme that exists in all living cells, NAD+ plays a central role in the body's biological processes, such as regulating cellular energy, increasing insulin sensitivity and reversing mitochondrial dysfunction.

When the body ages, NAD+ levels significantly decrease, dropping by middle age to about half the levels of youth, contributing to age-related metabolic diseases and neurodegenerative disorders. Numerous studies have shown restoring NAD+ levels safely improves overall health and increases life span in yeast, mice and dogs. Clinical trials testing the molecule in humans have been underway for three years, Sinclair said.

"These supplements, and the lifestyle that I am doing, is designed to turn on our defenses against aging," he said. "Now, if you do that, you don't necessarily turn back the clock. These are just things that slow down epigenetic damage and these other horrible hallmarks of aging.

"But the real advance, in my view, was the ability to just tell the body, 'Forget all that. Just be young again,' by just flipping a switch. Now I'm not saying that we're going to all be 20 years old again," Sinclair said.

"But I'm optimistic that we can duplicate this very fundamental process that exists in everything from a bat to a sheep to a whale to a human. We've done it in a mouse. There's no reason I can think of why it shouldn't work in a person, too."

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The 'Benjamin Button' effect: Scientists can reverse aging in mice. The goal is to do the same for humans - KITV Honolulu

Patients

Patients were18years old with reported post-COVID-19 cognitive symptoms that affected their quality of life and persisted for more than three months following an RT-PCR test confirming a symptomatic SARS-CoV-2 infection. Patients were excluded if they had a history of pathological cognitive decline, traumatic brain injury or any other known non-COVID-19 brain pathology. The inclusion and exclusion criteria are listed Supplementary information.

A prospective randomized, double blind, sham-controlled, phase II exploratory study was conducted from December 14, 2020, to December 27, 2021, at Shamir Medical Center (SMC), Israel. After signing an informed consent, patients were randomized to either HBOT or sham-control groups in a 1:1 ratio according to a computerized randomization table, supervised by a blinded researcher. To evaluate participant masking, patients were questioned after the first session on their perception regarding the treatment they received. Evaluation procedure was done at baseline and 13weeks after the last HBOT/control session. All evaluators were blinded to the patients group allocation. The study was approved by SMCs Institutional Review Board (IRB) (No. 332-20-ASF) and all participants signed an informed consent prior to their inclusion. All research was performed according to the relevant guidelines and regulations. This study was registered with ClinicalTrials.gov, number NCT04647656 on 01/12/2020.

Both HBOT and sham protocols were administrated in a multi-place Starmed-2700 chamber (HAUX, Germany). The protocol comprised of 40 daily sessions, five sessions per week within a two-month period. The HBOT protocol included breathing 100% oxygen by mask at 2ATA for 90min with five-minute air breaks every 20min. Compression/decompression rates were 1.0m/min. The sham protocol included breathing 21% oxygen by mask at 1.03 ATA for 90min. To mask the controls, the chamber pressure was raised up to 1.2 ATA during the first five minutes of the session along with circulating air noise followed by decompression (0.4m/min) to 1.03 ATA during the next five minutes.

The primary outcome of the study was the cognitive assessment as evaluated by the Mindstreams computerized cognitive testing battery (NeuroTrax Corporation, Bellaire, TX). This assessment evaluates various cognitive domains including: memory, executive function, attention, information processing speed, and motor skills. Cognitive scores were normalized for age, gender and educational levels. The tests methods are described in the Supplementary information.

The secondary outcomes include the following measures:

Brain imaging MRI scans were performed on a MAGNETOM VIDA 3T scanner, configured with 64-channel receiver head coils (Siemens Healthcare, Erlangen, Germany). The MRI protocol included T2-weighted, 3D fluid attenuated inversion recovery (FLAIR), susceptibility weighted imaging (SWI), pre- and post-contrast high-resolution MPRAGE 3D T1-weighted, dynamic susceptibility conSupplementary informationtrast (DSC) for calculating whole-brain quantitative perfusion maps, and diffusion tensor imaging (DTI) for microstructure changes in grey and white matter determination. A detailed description is found in the . Briefly, preprocessing of DSC and DTI images was performed using the SPM software (version 12, UCL, London, UK) and included motion correction, co-registration with MPRAGE T1 images, spatial normalization, and spatial smoothing with a kernel size of 6mm full width half maximum (FWHM). Whole-brain quantitative perfusion analysis was performed as described in previous studies39,40. MR signal intensity was converted to Gd concentrations, AIF was determined automatically, fitted to the gamma variate function and deconvolved on a voxel-by-voxel basis to calculate brain perfusion maps.

Diffusion brain volumes denoising was performed using Joint Anisotropic LMMSE Filter for Stationary Rician noise removal41 and calculation of DTI-FA (fractional anisotropy) and MD (mean diffusivity) maps were performed using an in-house software written in Matlab R2021b (Mathworks, Natick, MA).

Included self-reported questionnaires were the short form-36 (SF-36) to assess quality of life, the Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality, the Brief Symptom Inventory (BSI-18) to evaluate psychological distress, based on three subscales: depression, anxiety, and somatization, and the Brief Pain Inventory (BPI) to measure pain intensity and impact.

The sense of smell was evaluated by the Sniffin Sticks Test (Burghardt, Wedel, Germany). The kit is standardized for age and gender. Taste was evaluated by a Taste Strip Test (Burghardt, Wedel, Germany), including four tastes: bitter, sour, salt and sweet.

Pulmonary function measurements were performed by a KoKo Sx1000 spirometer (Nspire health, USA). Blood samples were collected for complete blood count, chemistry and inflammatory markers. Participants were monitored for adverse events including barotraumas (either ear or sinuses), and oxygen toxicity (pulmonary and central nervous system). This article discusses cognitive and behavioral aspects of post-COVID-19 condition. Additional secondary outcomes including neuro-physical evaluation, cardiopulmonary exercise test, echocardiography, and functional brain imaging will be presented in future manuscripts.

Continuous data are expressed as meansstandard deviations (SD). Two-tailed independent t-tests with were performed to compare variables between groups when a normality assumption held according to a KolmogorovSmirnov test. Net effect sizes were evaluated using Cohen's d method, defined as the improvement from baseline after sham intervention was subtracted from the improvement after HBOT, divided by the pooled standard deviation of the composite score. Categorical data were expressed in numbers and percentages, compared by chi-square/Fishers exact tests. To evaluate HBOTs effect, a mixed-model repeated-measure ANOVA model was used to compare post-treatment and pre-treatment data. The model included time, group and the group-by-time interaction. A Bonferroni correction was used for the multiple comparisons. A value of p<0.05 was considered significant. Pearsons correlations were performed between perfusion and diffusion changes and the change in questionnaire scores before and after HBOT and sham. Imaging data analysis was performed on the normalized CBF, FA and MD maps, using the voxel-based method to generate statistical parametric maps. A gray matter mask was applied on the CBF and MD maps, and a white matter mask on the FA maps (using a threshold of 0.2). A within-subject repeated measure ANOVA model was used to test the main interaction effect between time and group implemented in SPM software (version 12, UCL, London, UK). A sequential Hochberg correction was used to correct for multiple comparisons (P<0.05)42. Data analysis was performed using Matlab R2021b (Mathworks, Natick, MA) Statistics Toolbox.

The estimated sample size was calculated based on our recent study in healthy adults19. A Mindstreams-NeuroTrax global cognitive score improvement of 5.2 and 0.8 points, with a standard deviation of 6.7 points was found in the HBOT and control groups respectively. Assuming a power of 80%, and 5% two-sided level of significance, a total of 74 participants would be required, 37 participants in each arm. Considering a dropout rate of 15% the total sample size required is 85.

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Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial | Scientific Reports -...

The new report by Expert Market Research titled, India Pet Grooming Products Market Size, Share, Price, Trends, Growth, Report and Forecast 2021-2026, gives an in-depth analysis of the countryspet grooming products market, assessing the market based on its segments like product type and distribution channels. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analysing the market based on the SWOT and Porters Five Forces models.

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The key highlights of the report include:

Market Overview (2016-2026)

Forecast CAGR (2021-2026): 13% (India Pet Care Market)

Pet grooming is one of the most important aspect of properly raising a pet. The market for pet grooming products in India is likely to be propelled by the rising awareness of pethealthand well-being. Proper grooming of pet is essential to prevent them from any kind ofdiseases. In India, the market for shampoos and conditioners is likely to grow at a healthy pace as the hairs of cats and dogs needs routine cleaning and nourishment. Also, the increasing use of e-commerce platforms for shopping of pet grooming products is expected to further aid the market growth in the forecast period of 2021-2026.

Industry Definition and Major Segments

Pet grooming is defined as the maintenance and well-being of pets. In includes all the products which are being used by pet owners to take proper care of their pets health and hygiene. By using grooming products, not just a pets good health is maintained but also its physical appearance is simultaneously enhanced.

Read Full Report with Table of Contents https://bityl.co/Casj

Firstly, the market has been segmented based on the product type as:

Shampoos and Conditioners Combs and Brushes Clippers and Scissors Others

Depending on the distribution channel, the Indias pet care market has also been segmented into:

Hypermarkets and Supermarkets Pet Stores Veterinary Clinics Online Others

Market Trends

The shift towards environment friendly products can also be seen in the pet grooming products market. Petveda is one such market player which provides several pet care and grooming products by combining Ayurvdeda and sciences. In 2021, Urban Essentials launched Pawsh, a grooming product range which is SLS and paraben free with no artificial colours orchemicals. Pawsh products have been manufactured using safe ingredients, such as coconut cleansers and essential oils. The new product launches in the market is likely to provide number of alternatives to the Indian pet owners for choosing an environment-friendly option for grooming their pets.

Key Market Players

The major players in the market are Glenand Group of Companies, Petacom, Petkin Inc., Wahl Clipper Corporation, Terrai Natural Products, Scoobee Pet Products, and others. The report covers the market shares, capacities, plant turnarounds, expansions, investments and mergers and acquisitions, among other latest developments of these market players.

About Us:

Expert Market Research is a leading business intelligence firm, providing custom and syndicated market reports along with consultancy services for our clients. We serve a wide client base ranging from Fortune 1000 companies to small and medium enterprises. Our reports cover over 100 industries across established and emerging markets researched by our skilled analysts who track the latest economic, demographic, trade and market data globally.

At Expert Market Research, we tailor our approach according to our clients needs and preferences, providing them with valuable, actionable and up-to-date insights into the market, thus, helping them realize their optimum growth potential. We offer market intelligence across a range of industry verticals which include Pharmaceuticals, Food and Beverage, Technology, Retail, Chemical and Materials, Energy and Mining, Packaging and Agriculture.

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India Pet Grooming Products Market To Be Driven By Increasing Pet Ownership And Rising Awareness About The Usage Of Pet Grooming Products In Forecast...

The new report by Expert Market Research titled, India Pet Grooming Products Market Size, Share, Price, Trends, Growth, Report and Forecast 2021-2026, gives an in-depth analysis of theIndia pet grooming products market, assessing the market based on its segments like applications, manufacturing process and major regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along with analyzing the market based on the SWOT and Porters Five Forces models.

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The key highlights of the report include:

Market Overview (2016-2026)

Forecast CAGR (2021-2026): 13%

Indias pet care market is expected to grow during the forecast period, owing to the growth of nuclear families, dual-income households, lifestyle choices, urbanization, and increased pet ownership. Delayed parenthood, which is prevalent among urban and newlywed couples, has boosted the countrys pet adoption rate, transforming it into an emotional stimulant. Dog care products are the markets largest segment, accounting for more than half of the market share. Consumer awareness about pet health and well-being is propelling Indias pet grooming products industry. The market is also benefiting from the growing popularity of cats and rabbits as pets. Additional factors, such as the growing number of manufacturers, innovations, and specialized products, are expected to significantly propel the markets growth. The growing presence of veterinary clinics and pet stores is also expected to contribute to the markets growth. Over the forecast period, rising disposable incomes and the growing concept of pet parenting amongst todays generation are expected to drive the market growth.

Industry Definition and Major Segments

Pet grooming is defined as the care and maintenance of pets. Grooming is necessary to maintain the pets health.

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By types, the market is divided into:

Shampoos and Conditioners Combs and Brushes Clippers and Scissors Others

By distribution channel, the market is divided into:

Hypermarkets and Supermarkets Pet Stores Veterinary Clinics Online Others

By region, the industry is categorized into:

North India South India East India West India

Market Trends

Most pet care products are distributed through veterinary clinics. In terms, of distribution channels, veterinary clinics account for the largest share in the market. The sectors growth has been aided by an increase in per-pet spending and increased pet ownership. Additionally, the countrys growing number of dog grooming salons is expected to increase demand for pet grooming products. Meanwhile, Indias increasing preference for online shopping is expected to accelerate the growth of the online sector. This will contribute significantly to the market growth over the forecast period.

Shampoos and conditioners make up a huge part of the market share. This is because the number of cases of hair loss, skin diseases, and other ailments is increasing amongst pets. Cats and dogs are the most popular pets, both of which have furs. As a result, they require extensive cleansing, conditioning, and deodorization. These factors are expected to contribute to the growth of the market during the forecast period.

Key Market Players

The major players in the market are Glenand Group of Companies, Petkin Inc., Petacom, Wahl Clipper Corporation, Terrai Natural Products, Scoobee Pet Products, among Others. The report covers the market shares, capacities, expansions, investments and mergers and acquisitions, among other latest developments of these market players.

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Expert Market Research is a leading business intelligence firm, providing custom and syndicated market reports along with consultancy services for our clients. We serve a wide client base ranging from Fortune 1000 companies to small and medium enterprises. Our reports cover over 100 industries across established and emerging markets researched by our skilled analysts who track the latest economic, demographic, trade and market data globally.

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India Pet Grooming Products Market To Be Driven By Rising Disposable Income And The Growing Concept Of Pet Parenting During Forecast Period Of...

New York, June 27, 2022 (GLOBE NEWSWIRE) -- The global animal stem cell therapy market recorded sales of around US$ 249.9 Mn in 2021 and the market is predicted to experience healthy growth over the years ahead at a CAGR of 5.2% (2022 to 2032).

Animal stem cell therapies are treatments for disorders such as arthritis, soft tissue injuries, traumatic fractures, tendonitis, inflammatory bowel disease, and others that are given to animals. Hematopoietic stem cells and mesenchymal stem cells are used in these treatment procedures.

As the focus on giving animals a better quality of life grows, so does the adoption of such therapies across the world. The market for animal stem cell therapy is predicted to continuously increase owing to the growing need for higher levels of veterinary care.

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Regulatory bodies are also encouraging veterinary regenerative medicine research & development.

The European Commission has approved a few stem cell-based products within the region.

The animal stem cell therapy market is moderately fragmented with a few key market players and presents numerous opportunities for new market entrants to create a foothold in the industry. Increased pet adoption rate can be a beneficial factor for manufacturers of stem cells to expand into emerging markets.

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Key Takeaways from Market Study

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With rising disposable incomes and higher adoption rate of pet animals, the global market for animal stem cell therapy is set to gain traction over the coming years, says an analyst of Persistence Market Research.

Market Competition

Key animal stem cell therapy providers are investing in innovating veterinary regenerative medicines and they are also coming up with new product launches for the well-being of animals.

Along with product innovation, market players are also aiming for various collaborations to strengthen their R&D in the field of animal stem cell therapy.

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What Does the Report Cover?

Persistence Market Research offers a unique perspective and actionable insights on the animal stem cell therapy market in its latest study, presenting historical demand assessment of 2012 2021 and projections for 2022 2032.

The research study is based on product type (hemopoietic stem cells and mesenchymal stem cells), source (allogeneic and autologous), indication (osteoarthritis, soft tissue injuries, traumatic fractures, tendonitis, inflammatory bowel disease, and others), species (canine, feline, and equine), and end user (veterinary hospitals, veterinary clinics, and veterinary research institutes), across seven key regions of the world.

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Business intelligence is the foundation of every business model employed by Persistence Market Research. Multi-dimensional sources are being put to work, which include big data, customer experience analytics, and real-time data collection. Thus, working on micros by Persistence Market Research helps companies overcome their macro business challenges.

Persistence Market Research is always way ahead of its time. In other words, it tables market solutions by stepping into the companies/clients shoes much before they themselves have a sneak pick into the market. The pro-active approach followed by experts at Persistence Market Research helps companies/clients lay their hands on techno-commercial insights beforehand, so that the subsequent course of action could be simplified on their part.

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Animal Stem Cell Therapy Market projected CAGR of 5.2% for the next ten years (2022-2032) Persistence Market Research - GlobeNewswire

The biotechs all new neurorestorative approach aims to rebuild and replace lost brain cells in Alzheimers that underlies clinical symptoms.

On the back of the trial, the company plans to launch a world-first human trial in 2024.

The veterinary trial, led by Skin2Neuron and published this month in Stem Cell Research and Therapy, reversed the dementia-like syndrome that strikes down many older pet dogs with Alzheimers.

Dementia was reversed in more than half of the canine patients, with a clinically meaningful improvement in 80%. Typically, improvement lasted around two years.

Skin2Neuron champions its new approach as a ray of hope for Alzheimers disease: championing a completely different approach to the amyloid hypothesis of Alzheimers disease.

Our target is the ultimate cause of dementia: lost neurons and synapses. We do this by microinjecting a patients own HFN cells directly into the hippocampus, the brains memory center and first area to be devastated by Alzheimers, explains the company.

While its lead therapeutic target is Alzheimers, it says its technology also has potential to treat neurodegenerative conditions such as Parkinsons disease, Amyotrophic Lateral Sclerosis and more.

A dogs thinking neocortex and hippocampus is similar to the human brain, says the company. Meanwhile, older dogs often develop a dementia syndrome similar to human dementia: becoming forgetful, irritable, lost, wandering around aimlessly, failing to recognize owners and experiencing disrupted sleep.

"Because of deep parallels between the canine brain and human brain, and canine Alzheimer's and human Alzheimer's, I started this trial 10 years ago with the assumption that if it's going to work in humans, then it needs to work in dogs first. And the results exceeded my wildest expectations, said co-founder Professor Michael Valenzuela.

"The hippocampus, the memory center of the brain, was packed with baby neurons and new synapses, precisely where we delivered the cells. Compared to untreated dogs, it was like night and day".

Microscopic analysis confirmed the dogs had classic Alzheimer pathology: meaning the cell therapy worked in the setting of natural disease, a first of its kind, according to the company.

"Given our doggie patients also had many of the same health issues that older people face, it gives me even greater confidence," said Valenzuela.

Study:Valenzuela, M., Duncan, T., Abey, A.et al.Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial.Stem Cell Res Ther13,261 (2022). https://doi.org/10.1186/s13287-022-02933-w

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'A new Alzheimer's treatment is on the horizon': Cell therapy reverses dementia-like syndrome in dogs - BioPharma-Reporter.com

His plight tugged at the heartstrings of dog lovers all over the country when rescuers discovered an abandoned puppy who was suffering from almost 100 gun shot wounds

The dog was just about six months old when he was reported as a stray to Friends of Rescue in Derry and the charity volunteers were horrified to discover his coat was hiding severe injuries and starvation. They called him Darragh and started him on the road to recovery.

And today, almost two months on the Belgian shepherd has made a remarkable recovery is ready to find his forever home.

Read more: Could you manage your dog at your workplace?

A spokesperson for the charity said: "Our handsome Darragh is now fully recovered and ready to find his own family.

"Darragh was found cowering at the side of the road at only six months old unable to move. When we got him to safety we realised he was covered in wounds but under his heavy coat it was difficult to see.

"We had to shave him right down and then it was discovered that Darragh had been shot. There were more than 90 pellets in his body that we could clearly see in his X-ray and he has had a few surgeries since to remove the ones that could be safely reached.

"He was emaciated when he arrived, weighing just 12.8kg, but now weighing a fabulous 24kg he is looking so well - in fact he is well enough that he has been signed off by our vet as a healthy boy, so he is ready for adoption."

The team say Darragh is understandably shy and nervous about meeting new people and facing new experiences, but he comes round with patience and understanding as he has with his foster family.

And his new family will need to work with him to allow him to blossom at his own pace and work on his confidence with gentle reassurance and guidance

A spokesperson said: "Once he's comfortable you will see he is an absolute sweetheart and an absolute eejit. He loves curling up on the sofa when he's not trying to play with a toy or lick you to get a pet.

"Many people mistake Darragh for a Dutch shepherd because of his shorter hair, but he had been shaved and now its slowly growing back. Darragh is actually a Belgian shepherd so he will have long flowing hair and be stunning.

He doesnt like being alone, although crate trained he likes to know youre there, so no long working hours

He can live with cats

He will need a few meetings with any dog in the home

No kids under 10

Suzanne Fleming from the charity said: "His recovery is incredible and he is such a lovely boy. Darragh deserves a fantastic forever loving home and we hope to secure that for him as soon as possible. In the meantime he is in foster care where he is treated as family and loved 100%.

"Sadly he is not the only dog who needs out help and we are working at full capacity with vet bills mounting and the stream of animals in need of urgent care increasing daily.

"But while we continue to pick up after other peoples possessions we will always have to ask for help, so we hope you hear our plea. We simply cannot keep taking in any more animals without getting our vets bills down."

Darragh was found near stables close to Lenamore Rd, Co Derry. He was taken to a foster home for triage where his wounds were examined and then on to VetsForPets in Crescent Link, Derry, where he had about 90 lead pellets removed from his body, including 50 from around his neck.

Darragh's treatment and rehabilitation, feeding and medical costs were added to the most recent list of animals in need at Friends of rescue.

And dogs like Darragh need long term care, fostering and then a search for the right home to adopt him with costs rising daily.

Suzanne said: "Rescuing animals is heart breaking and it doesn't get easier. This poor pup was found lying alone near a stables in Co Derry, he had been left to die. Darragh didn't deserve this, no animal does. But he had no voice and so it's up to rescues like us to set in to protect the vulnerable, the ones who need us most and Darragh is the prime example of why we do what we do."

Darragh was discovered by a man who was out hacking on his horse, who spotted the dark bundle in the undergrowth and discovered it was a young dog who was lying motionless.

He called the Friends of Rescue for help and they discovered the dog had suffered around 100 injuries from lead pellet blasts.

Darragh's timeline

Suzanne said: We would also like to say a massive thank to everyone who has helped in any way towards Darragh's medical treatment, recovery and rehabilitation and to @filo for Darraghs Box of Love. To say he loved it was an understatement.

"Darragh is just one of the animals who has had extensive treatment in his time with us, and we cant continue our work without the generosity of the public.

If you would like to help Friends of rescue as they continue to help abused, abandoned and neglected animals, you can donate to them via Vets4Pets Crescent Link in person or via phone on 02871314420 or visit the charity's Paypal account by clicking here.

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Shot with 90 pellets and abandoned, but today Derry dog Darragh is ready for loving home - Belfast Live