Chulalongkorn Universitys Faculty of Veterinary Science and the Faculty of Engineering have worked together to research and develop a three-dimensional artificial cornea from stem cells that offers a way to treat deep corneal wounds in dogs. The innovation helps to solve the problem of treatment methods that rely on tissue replacement which is hard to find and very expensive. It makes it possible for dogs to be able to see clearly and comfortably once again.

Does your dog have any of these symptoms? The inability to fully open its eyes, squinting or blinking frequently, shedding lots of tears, sometimes the tears are thick, and the mucus appears greenish. The sclera is unusually red and not clear like before. The cornea becomes cloudy and there are blood vessels in it.

If your answer is yes then your pet might be suffering from a corneal ulcer which, if left untreated could eventually cause blindness.

Nowadays, the number of dogs receiving treatment for corneal ulcers has increased tremendously.The small animal hospital at the Faculty of Veterinary Medicine, Chulalongkorn Universityalone is already treating dogs with corneal ulcers daily.

Veterinarian Dr. Chutirat Torssahakul,the Department of Internal Medicine, Faculty of Veterinary Medicine

We find quite a number of lesions like this in dogs. Corneal ulcers occur as a result of many reasons, such as dogs scratching their own eyes because they have allergies causing itching around the eyes followed by scratching until the lesions form. Fights with other dogs, being scratched by a cat, or accidentally bumps into objectsVeterinarian Dr. Chutirat Torssahakul of the Department of Internal Medicine,Faculty of Veterinary Medicine, Chulalongkorn Universityaddressed the problems that became the starting point for the research and innovation development. Three-dimensional artificial cornea from stem cells enables your beloved pet to have perfect vision once again. The current treatment being used is to have grafts made from replacement tissue derived from porcine bladder or canine placentas which are rare and relatively expensive. There is also the possibility of causing post-surgery reaction and inflammation. Therefore, we thought that if we could produce our own innovative artificial cornea using natural materials that are easily found and reduce the chance of causing inflammation this might be a better option. Dr. Chutirat explained.

Three-dimensional artificial cornea from stem cells a brighter alternative

As a result of the effort and intention to solve eye problems for dogs, the Faculty of Veterinary Sciences research team throughthe Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC)has therefore embarked on additional studies on stem cells and is working with the Biomedical Engineering Research Center of the Faculty of Engineering, Chulalongkorn University recognizing its expertise in tissue engineering to help make adhesive materials for growing stem cells.

Image showing a 3D corneal patch made from silk fibroin and gelatin

According to Veterinary Professor Dr. Chutirat Artificial corneal tissue is obtained by cultivating real dog corneal stem cells on a natural material structure made from silk fibroin mixed with gelatin. The material can be cheaply and easily found in Thailand. It is strong and durable, clear and transparent, and adheres well to cells making them three-dimensional which is comparable to real corneal tissue.

This innovation can be used to treat corneal perforations in dogs as well as large corneal wounds where the tissue cannot be stitched or even deep wounds in which a large amount of corneal tissue has been lost. In cases of dogs with mild or moderate levels of corneal ulcer problems, currently, 2 methods for treatment are still in use.

But in cases where the wound in the cornea is so large that tissue must be used to replace the missing part, we usually use a graft which could be the dogs own conjunctiva. The other option is to use replacement tissue such as tissues derived from human or canine placentas. These are costly and difficult to find so we have invented a new way to treat them and that is the three-dimensional artificial cornea made from stem cells.

4 outstanding features of the 3D artificial cornea innovation

At present, the 3D artificial cornea from stem cells innovation is still in the laboratory testing stage to study whether the 3D artificial cornea can actually be used as a cornea replacement, and to determine how it interacts with the animals body. According to Veterinary Professor Dr. Chutirat in many countries research on such innovations is also currently underway at the laboratory level.

The research we have done has produced satisfactory results. It is expected that this innovation will be applied to dogs in the next few years. Moreover, we have plans to apply this knowledge to cats as well from cell collection, locating cells, separating cells, and arranging cells Dr. Chutirat concluded.

Those who are interested can further read the research paper on the subject at https://pubmed.ncbi.nlm.nih.gov/35120168/

Original post:
3D Artificial Cornea from Stem Cells: Chula Researchers Advance Canine Corneal Wound Treatment - Times Higher Education

Global Animal Stem Cell Therapy

In recent years, animal stem cell therapy has emerged as a promising avenue in veterinary medicine, offering novel solutions for treating various diseases and injuries in companion and livestock animals. Amidst evolving regulatory landscapes, technological advancements, and the lingering effects of the COVID-19 pandemic, understanding the dynamics of the global animal stem cell therapy market is paramount. This blog delves into the size, share, and impact of factors shaping the market from 2023 to 2031.

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The animal stem cell therapy market encompasses a range of products and services aimed at harnessing the regenerative potential of stem cells to treat conditions such as osteoarthritis, tendon injuries, and inflammatory bowel disease in animals. Key factors influencing market growth include resin type, application, technology, end-use industry, and regional trends.

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Resin type plays a crucial role in the development and manufacturing of stem cell therapy products for animals. Common materials used in cell culture and scaffold fabrication include synthetic polymers, hydrogels, and extracellular matrix components. Advances in biomaterials science continue to drive innovation, enhancing the efficacy and safety of stem cell-based treatments. Animal stem cell therapy finds applications across diverse veterinary specialties, including orthopedics, neurology, oncology, and wound healing. From autologous stem cell transplantation to allogeneic cell products, the market offers a spectrum of treatment modalities tailored to individual patient needs. Growing awareness of regenerative medicine principles and increasing pet ownership drive market demand.

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Technological advancements play a pivotal role in advancing animal stem cell therapy, facilitating cell isolation, expansion, differentiation, and delivery. Innovations such as automated cell culture systems, three-dimensional bioprinting, and gene editing technologies enhance the scalability and precision of stem cell-based treatments. Moreover, advancements in cryopreservation techniques ensure long-term storage and viability of stem cell products. The end-use industry encompasses veterinary clinics, research institutions, biotechnology companies, and pharmaceutical manufacturers. Collaborations between academia and industry drive translational research and commercialization of stem cell therapies. Moreover, partnerships between veterinary professionals and stem cell therapy providers enhance patient access and clinical outcomes.

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Geographic variations in the animal stem cell therapy market reflect differences in regulatory frameworks, healthcare infrastructure, and socioeconomic factors. While developed regions such as North America and Europe boast robust veterinary healthcare systems and regulatory pathways, emerging economies in Asia-Pacific and Latin America present untapped opportunities for market expansion. Moreover, the COVID-19 pandemic has influenced market dynamics, reshaping healthcare priorities and accelerating digital health solutions.

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Originally posted here:
"Charting the Course: Global Animal Stem Cell Therapy Market - openPR