For the 13 patients treated at the recommended phase 2 dose (RP2D) the response rate after one cycle of treatment remains at 100% with a 38.5% complete response (CR) rate; one additional patient completed cycle 1 at the RP2D and was assessed with a partial response (PR)Three of 3 patients treated with two cycles in the dose escalation part of the study at the RP2D remain in CR at 6 months after start of treatmentSide effect profile shows only five instances of transient infusion-related reactions (IRR) in more than 100 AFM13 infusions with no episodes of neurotoxicity, CRS or GvHD

HEIDELBERG, Germany, Dec. 09, 2021 (GLOBE NEWSWIRE) -- Affimed N.V. (Nasdaq: AFMD), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer will host today a financial community call to discuss recent findings from the investigator sponsored trial (IST) at The University of Texas MD Anderson Cancer Center investigating the treatment of CD30-positive lymphoma patients with its innate cell engager (ICE) AFM13, pre-complexed with cord blood-derived natural killer (cbNK) cells (AFM13-104).

A treatment cycle consists of lymphodepleting chemotherapy with fludarabine and cyclophosphamide followed two days later by a single infusion of cytokine-preactivated and expanded cbNK cells that are pre-complexed with AFM13, followed by three weekly infusions of AFM13 (200 mg) monotherapy. Responses are assessed on day 28 by FDG-PET and patients can receive up to two cycles. Three patients were treated with 1106, three patients with 1107 and 13 patients with 1108 AFM13-pre-complexed cbNK cells per kg body weight.

Response Assessment

A total of 19 patients with CD30-positive relapsed or refractory Hodgkin and non-Hodgkin lymphomas (17 and 2 patients, respectively) have been treated to date across three dose cohorts. According to investigator assessment, 17 of 19 patients had achieved an objective response (ORR 89.5%) to the treatment, with seven complete responses (CR 36.8%) and ten partial responses (PR 52.6%).

In patients treated at the RP2D level of 1x108 cbNK cells per kg, 12 of 13 had classical Hodgkin lymphoma and 1 patient had CD30-positive NHL. In this cohort, 100% of patients responded after the first cycle of treatment with five CRs (38.5%) and seven PRs (61.5%). All patients treated at the RP2D have now received a second cycle of therapy. Response evaluation after cycle 2 will be reported at a future scientific conference.

Initial Durability of Response Observations

Nine patients treated in the dose escalation phase of the study had follow-up at 6 months. Of note, the three patients treated at the RP2D remain in remission at 6 months after start of treatment, two without additional treatment and one on anti-PD-1 antibody maintenance.

In the four responders out of six treated at the two lower dose levels, one patient, who started treatment in September 2020, remains in remission after consolidation autologous stem cell transplant, and three relapsed at 3.4, 4.8 and 6.3 months after start of therapy.

Safety

Five reported cases of transient infusion related reactions were reported after the monotherapy infusions of AFM13. Of note, there were no instances of serious adverse events such as cytokine release syndrome, immune cell-associated neurotoxicity syndrome or graft-versus-host disease.

Conference Call/Webcast Information

The event today will include a review of Affimeds approach to activating the innate immune system in the fight against cancer, preclinical data supporting the combination of Affimeds ICE molecules with adoptive NK cell transfer, a review of the treatment challenges and clinical opportunities for CD30+ lymphomas, and review of the interim data from AFM13-104 by the studys principal investigator, Yago L. Nieto, M.D., Ph.D., professor of Stem Cell Transplantation and Cellular Therapy at of The University of Texas MD Anderson Cancer Center.

Affimed will host a conference call and webcast today, December 9th, 2021, at 8:30 a.m. EST. To access the call, please dial +1 (409) 220-9054 for U.S. callers, or +44 (0) 8000 323836 for international callers, and reference passcode 3065475 approximately 15 minutes prior to the call.

A live audio webcast of the conference call will be available in the Webcasts section on the Investors page of the Affimed website at https://www.affimed.com/webcasts/investor-day/ or https://edge.media-server.com/mmc/p/zzwismtq. A replay of the webcast will be accessible at the same link for 30 days following the call.

About the Phase 1-2 Study

The University of Texas MD Anderson Cancer Center is studying AFM13 in an investigator-initiated phase 1-2 trial in combination with cord blood-derived allogeneic NK cells in patients with recurrent or refractory CD30-positive lymphomas. The first phase of this study involves dose escalation of pre-complexed NK cells, with patients receiving lymphodepleting chemotherapy followed by 1106 NK cells/kg in Cohort 1; 1107 NK cells/kg in Cohort 2; and 1108 NK cells/kg in Cohort 3. The trial is designed to explore safety and to determine the recommended phase 2 dose and evaluate its activity. The recommended phase 2 dose was determined as 1108 NK cells/kg. In each cohort, the dose of the pre-complexed NK cells with AFM13 is followed by weekly doses of 200 mg AFM13 monotherapy for three weeks, with each patient evaluated for dose-limiting toxicities and responses on day 28. MD Anderson has an institutional financial conflict of interest with Affimed related to this research and has therefore implemented an Institutional Conflict of Interest Management and Monitoring Plan. Additional information about the study can be found at http://www.clinicaltrials.gov (NCT04074746).

About AFM13

AFM13 is a first-in-class innate cell engager (ICE) that uniquely activates the innate immune system to destroy CD30-positive hematologic tumors. AFM13 induces specific and selective killing of CD30-positive tumor cells, leveraging the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages. AFM13 is Affimeds most advanced ICE clinical program and is currently being evaluated as a monotherapy in a registration-directed trial in patients with relapsed/refractory peripheral T-cell lymphoma or transformed mycosis fungoides (REDIRECT). The study is actively recruiting. Additional details can be found at http://www.clinicaltrials.gov (NCT04101331).

About Affimed N.V.

Affimed (Nasdaq: AFMD) is a clinical-stage immuno-oncology company committed to give patients back their innate ability to fight cancer by actualizing the untapped potential of the innate immune system. The companys proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly owned and partnered single agent and combination therapy programs. The ROCK platform predictably generates customized innate cell engager (ICE) molecules, which use patients immune cells to destroy tumor cells. This innovative approach enabled Affimed to become the first company with a clinical-stage ICE. Headquartered in Heidelberg, Germany, with offices in New York, NY, Affimed is led by an experienced team of biotechnology and pharmaceutical leaders united by a bold vision to stop cancer from ever derailing patients lives. For more about the companys people, pipeline and partners, please visit: http://www.affimed.com.

Forward-Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as anticipate, believe, could, estimate, expect, goal, intend, look forward to, may, plan, potential, predict, project, should, will, would and similar expressions. Forward-looking statements appear in a number of places throughout this release and include statements regarding our intentions, beliefs, projections, outlook, analyses and current expectations concerning, among other things, the potential of AFM13, AFM24, and our other product candidates, the value of our ROCK platform, our ongoing and planned preclinical development and clinical trials, our collaborations and development of our products in combination with other therapies, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals for our product candidates, our intellectual property position, our collaboration activities, our ability to develop commercial functions, clinical trial data, our results of operations, cash needs, financial condition, liquidity, prospects, future transactions, growth and strategies, the industry in which we operate, the trends that may affect the industry or us, impacts of the COVID-19 pandemic, the benefits to Affimed of orphan drug designation and the risks, uncertainties and other factors described under the heading Risk Factors in Affimeds filings with the SEC. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future.

Investor Relations Contact Alexander Fudukidis Director, Head of Investor Relations E-Mail: a.fudukidis@affimed.com Tel.: +1 (917) 436-8102

Media Relations Contact Mary Beth Sandin Vice President, Marketing and Communications E-Mail: m.sandin@affimed.com Tel.: +1 (484) 888-8195

Read the original:
Affimed to Host Virtual Investor Call Today to Discuss Treatment of CD30-positive Lymphoma ... - The Bakersfield Californian

For patients with previously untreated Richters transformation (RT), treatment with venetoclax, obinutuzumab, and atezolizumab led to high rates of remission, according to results presented at the 2021 American Society of Hematology Annual Meeting.

In previous studies, BCL2 inhibitor venetoclax and CD20 monoclonal antibody obinutuzumab have shown clinical activity in patients with diffuse large B-cell lymphoma (DLBCL) and RT. PD-L1 checkpoint inhibitor atezolizumab has been approved by the FDA for the treatment of melanoma, lung cancer, and other solid tumors.

From March 2020 to June 2021, researchers led by Nitin Jain, MD, of MD Anderson Cancer Center, enrolled eight patients with DLBCL RT in a phase II trial. Eligible patients with either previously untreated (n = 7) or relapsed/refractory (n = 1) RT were at least 18 years of age, had adequate organ function, and had not undergone prior treatment with venetoclax.

The median age of patients in the study was 70 years (range = 52-80). Patients had previously been treated for CLL with ibrutinib (n = 4), chlorambucil plus obinutuzumab followed by acalabrutinib (n = 1), bendamustine-rituximab (n = 1). All six patients for whom CLL IGHV mutation status was available were IGHV-mutated. Three patients had complex karyotype, three had a TPS53 mutation, and two had a NOTCH1 mutation. CLL FISH panel found the following:

Treatment consisted of the following:

Responses were evaluated using PET imaging and bone marrow aspirate/biopsy with measurable residual disease (MRD) assessment at the end of cycles 1, 4, 9, and 26. All seven patients achieved a response, including five complete metabolic responses and two partial metabolic responses. All but one of the responses occurred after the introduction of venetoclax in cycle 2. The remaining patient achieved complete metabolic response and bone marrow undetectable MRD after cycle 1.

Three patients underwent allogeneic stem cell transplant (alloSCT) in complete metabolic remission after 4.1, 4.2, and 6.6 months. Bone marrow undetectable MRD remission was also achieved in these three patients. One of the three has since relapsed and is currently receiving salvage therapy, the authors noted.

One patient who achieved partial metabolic remission relapsed prior to a planned alloSCT in cycle 8, but after treatment with a non-covalent BTK inhibitor, is now in remission, they added. Three patients continue to receive treatment on the trial in cycle 2, cycle 5, and cycle 12.

The patient with relapsed/refractory RT was a 58-year-old male with previously untreated CLL (unmutated IGHV, del17p, TPS53 mutation, and NOTCH1 mutation). Prior to enrollment in the trial, this patient received R-CHOP for three cycles but had no response.

No deaths were observed during follow-up. One patient developed pancreatitis associated with checkpoint inhibitor treatment and diabetes mellitus. Another patient required the venetoclax dose to be reduced to 400 mg daily.

Although this study is limited by its small sample size, these results are encouraging in relation to combined ibrutinib plus nivolumab in previously untreated RT, Dr. Jain wrote.

Read the original here:
Evaluating Venetoclax, Obinutuzumab, and Atezolizumab in Patients With Richters Transformation - DocWire News

HEIDELBERG, Germany, Nov. 22, 2021 (GLOBE NEWSWIRE) -- Affimed N.V. (Nasdaq: AFMD), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, today announced interim clinical results from the investigator-initiated phase 1-2 study at The University of Texas MD Anderson Cancer Center, evaluating cbNK cells pre-complexed with Affimeds innate cell engager (ICE) AFM13.

As of October 31, 2021, a total of 18 patients with CD30-positive relapsed or refractory Hodgkin and non-Hodgkin lymphomas (16 and 2 patients, respectively) were treated with the novel combination of cbNK cells pre-complexed with AFM13. A treatment cycle consists of lymphodepleting chemotherapy with fludarabine and cyclophosphamide followed two days later by a single infusion of cytokine-preactivated and expanded cbNK cells that are pre-complexed with AFM13, followed by three weekly infusions of AFM13 (200 mg) monotherapy. Responses are assessed on day 28 by FDG-PET and patients can receive up to two cycles. Three patients were treated with 1x106, three patients with 1x107 and 12 patients with 1x108 AFM13-pre-complexed cbNK cells per kg body weight.

As of the cutoff date, 16 of 18 patients had achieved an objective response to the treatment according to investigator assessment, with seven complete responses (CR) and nine partial responses (PR). Eleven of twelve patients treated at the recommended phase 2 dose level of 108 cbNK cells per kg had Hodgkin Lymphoma. In this cohort of patients treated at the recommended phase 2 dose, 100% responded after the first cycle of treatment with five CRs and seven PRs according to investigator assessment. Each of the patients in this cohort is eligible for a second treatment cycle, and updated data from this cohort will be reported at a later date. Treatment was well tolerated with five reported cases of transient infusion related reactions after the monotherapy infusions of AFM13. Of note, there were no instances of serious adverse events such as cytokine release syndrome, immune cell-associated neurotoxicity syndrome or graft-versus-host disease.

The patients enrolled in this study were all heavily pre-treated with a median of 6 lines of prior therapy and had progressive disease after their previous line of therapy, said Dr. Andreas Harstrick, Chief Medical Officer at Affimed. We are encouraged by the response rates that we continue to observe in these difficult to treat patients. The data are in line with data presented at AACR earlier this year. We also continue to see a very good safety profile of the combination, which is important as many of these patients have been very heavily pretreated and cannot tolerate aggressive therapies. Combining our ICE molecules with NK cells is an integral part of our strategy to bring innovative therapies to patients in need. We believe these preliminary data provide further validation of this approach.

Conference Call/Webcast Information

Affimed will host a conference call and webcast on December 9th, 2021, at 8:30 a.m. EST to review the data. Affimeds management will discuss the results to date, the current treatment landscape for CD30+ lymphomas, and next steps for the study. Dr. Yago L. Nieto, M.D., Ph.D, Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine from M.D Anderson Cancer Center will also be available during the call.

To access the call, please dial +1 (409) 220-9054 for U.S. callers, or +44 (0) 8000 323836 for international callers, and reference passcode 3065475 approximately 15 minutes prior to the call.

A live audio webcast of the conference call will be available in the Webcasts section on the Investors page of the Affimed website at https://www.affimed.com/investors/webcasts_cp/ or https://edge.media-server.com/mmc/p/zzwismtq. A replay of the webcast will be accessible at the same link for 30 days following the call.

About the Phase 1-2 Study

The University of Texas MD Anderson Cancer Center is studying AFM13 in an investigator-initiated phase 1-2 trial in combination with cord blood-derived allogeneic NK cells in patients with recurrent or refractory CD30-positive lymphomas. The first phase of this study involves dose escalation of pre-complexed NK cells, with patients receiving lymphodepleting chemotherapy followed by 1106 NK cells/kg in Cohort 1; 1107 NK cells/kg in Cohort 2; and 1108 NK cells/kg in Cohort 3. The trial is designed to explore safety and to determine the recommended phase 2 dose and evaluate its activity. The recommended phase 2 dose was determined as 1x108 NK cells/kg. In each cohort, the dose of the pre-complexed NK cells with AFM13 is followed by weekly doses of 200 mg AFM13 monotherapy for three weeks, with each patient evaluated for dose-limiting toxicities and responses on day 28.

MD Anderson has an institutional financial conflict of interest with Affimed related to this research and has therefore implemented an Institutional Conflict of Interest Management and Monitoring Plan.

Additional information about the study can be found at http://www.clinicaltrials.gov (NCT04074746).

About AFM13

AFM13 is a first-in-class innate cell engager (ICE) that uniquely activates the innate immune system to destroy CD30-positive hematologic tumors. AFM13 induces specific and selective killing of CD30-positive tumor cells, leveraging the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages. AFM13 is Affimeds most advanced ICE clinical program and is currently being evaluated as a monotherapy in a registration-directed trial in patients with relapsed/refractory peripheral T-cell lymphoma or transformed mycosis fungoides (REDIRECT). The study is actively recruiting. Additional details can be found at http://www.clinicaltrials.gov (NCT04101331).

About Affimed N.V.

Affimed (Nasdaq: AFMD) is a clinical-stage immuno-oncology company committed to give patients back their innate ability to fight cancer by actualizing the untapped potential of the innate immune system. The companys proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly owned and partnered single agent and combination therapy programs. The ROCK platform predictably generates customized innate cell engager (ICE) molecules, which use patients immune cells to destroy tumor cells. This innovative approach enabled Affimed to become the first company with a clinical-stage ICE. Headquartered in Heidelberg, Germany, with offices in New York, NY, Affimed is led by an experienced team of biotechnology and pharmaceutical leaders united by a bold vision to stop cancer from ever derailing patients lives. For more about the companys people, pipeline and partners, please visit: http://www.affimed.com.

Forward-Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as anticipate, believe, could, estimate, expect, goal, intend, look forward to, may, plan, potential, predict, project, should, will, would and similar expressions. Forward-looking statements appear in a number of places throughout this release and include statements regarding our intentions, beliefs, projections, outlook, analyses and current expectations concerning, among other things, the potential of AFM13, AFM24, and our other product candidates, the value of our ROCK platform, our ongoing and planned preclinical development and clinical trials, our collaborations and development of our products in combination with other therapies, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals for our product candidates, our intellectual property position, our collaboration activities, our ability to develop commercial functions, clinical trial data, our results of operations, cash needs, financial condition, liquidity, prospects, future transactions, growth and strategies, the industry in which we operate, the trends that may affect the industry or us, impacts of the COVID-19 pandemic, the benefits to Affimed of orphan drug designation and the risks, uncertainties and other factors described under the heading Risk Factors in Affimeds filings with the SEC. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future.

Investor Relations Contact

Alexander FudukidisDirector, Investor RelationsE-Mail: a.fudukidis@affimed.comTel.: +1 (917) 436-8102

Media Contact

Mary Beth SandinVice President, Marketing and CommunicationsE-Mail: m.sandin@affimed.comTel.: +1 (484) 888-8195

View original post here:
Affimed Announces 100% Objective Response Rate at Highest Dose in Phase 1-2 Study of Cord Blood-derived Natural Killer Cells Pre-complexed with Innate...

The time to start planning for your pet's care during the busy holiday season is now and meet Bailey, a young girl looking for her forever family.

Halloween is over and that means the busy holiday season is now upon us. While many of us make plans for those, one thing that can slip through the cracks is getting a holiday pet plan in place.

The staff at the Humane Society of South Central Michigan (HSSCM) say if you are planning on leaving town over the holidays, now would be the time to make arrangements for your furry family member while you are away.

Another helpful tip is having a quiet place away from your family gathering where your pet can escape the noise and overstimulation. Along with that, make sure your pet is secured as groups come and go from your home and packages are being carried in and out.

Food is another thing to be aware of. There are many foods we eat during the holidays that should not be shared with cats and dogs. Find a list below of common foods that are poisonous to dogs and clickhere for a list of foods that should not be given to cats.

Miss Bailey is just shy of 5 months old. She is an Australian Shepherd mixedwith some possible Hound. But there are no breed guarantees. One thing for sure is Baily is a very sweet and beautiful girl. She can be a bit on the timid side but with some patience and encouragement, her confidence is sure to grow.

Bailey enjoys playing but also loves to snuggle once she's had time to get to know you. Due to her breed, a physically fenced-in yard is a must. Bailey loves to run and play outside. She may do well in a home with another dog, pending an approved application and meet and greet. She has not been tested with cats at this time. Bailey would do best in a home with children 8 years and older.

Would you like to makeBailey a forever part of your family?Click here to find an application (click the Adoption tab on the top left) to fill out and return to HSSCM.

Want to add a furry family member but maybe Bailey isn't the right fit? Click here to see other cats and dogs waiting for their forever home.

To prepare yourself for a potential incident, always keep your vet's phone number handy, along with an after-hours clinic you can call in an emergency. The ASPCA Animal Poison Control Center also has a hotline you can call at (888) 426-4435 for advice.

Even with all of these resources, however, the best cure for food poisoning is preventing it in the first place. To give you an idea of what human foods can be dangerous, Stacker has put together a slideshow of 30 common foods to avoid. Take a look to see if there are any that surprise you.

See original here:
Holiday Pet Safety Tips and Bailey the Featured Pet of the Week - wbckfm.com

Well, I made it about one sentence before I started tearing up while writing this. But before having Koda I didn't have that animal before. That one that teaches you how fantastic animals can be. I had pets growing up but it wasn't the same. Koda wasn't the same, he was something more, he was our special boy. Which is why it was so extremely hard to lose him yesterday as he ran free across that rainbow bridge.

We knew when he rescued us 11 years ago in Kalispell, Montana that he had a rough start to life as he was found tied to a stop sign left by his previous owners. That was the biggest mistake of their life as Koda was quickly welcomed into our home and our family. He immediately made life better, he was always happy, and always ready to play. He really was the perfect dog.

If Koda ever saw someone crying or just looking sad it took just seconds before he was right next to that person trying to lick their hand and give hugs letting that person know everything would be okay. Even yesterday as I was driving to Flint Veterinary Clinic, my boy held on so I could say goodbye, and minutes later he was gone. He lived his days caring about everyone else.

Something wasn't right with Koda in his final days, you could tell he wasn't himself. Not eating like normal and more tired than normal. There was fluid pushing on his heart and it just got to be too much. Luckily, our boy isn't hurting anymore. While it hurts us here, we can find a little bit of peace knowing he is in a better place now.

Remember to hug your pets, often. Here are some photos of our amazing Koda Friend:

We lost our boy as he crossed the rainbow bridge, but we are lucky for having him in our family for 11 years.

To prepare yourself for a potential incident, always keep your vet's phone number handy, along with an after-hours clinic you can call in an emergency. The ASPCA Animal Poison Control Center also has a hotline you can call at (888) 426-4435 for advice.

Even with all of these resources, however, the best cure for food poisoning is preventing it in the first place. To give you an idea of what human foods can be dangerous, Stacker has put together a slideshow of 30 common foods to avoid. Take a look to see if there are any that surprise you.

More and more, East Texans want restaurants where they can share a meal and hang out on a cool patio with their best furry friends. Here are TEN great spots in Tyler to do just that!

More:
We Lost a Good One, Koda Crossed the Rainbow Bridge - knue.com

Friday Night Lights glamorized and dramatized high school football on TV. Different areas have various levels of enthusiasm for the gridiron. In the Capital Region, this is a huge weekend coming up that will draw the attention of thousands of local fans and students. Section II high school football enjoys its brightest spotlight this week as the Section II football committee announced the Class AA, Class A, Class C and Class D championship times and locations on Sunday.

The big school game will be the Class AA championship between Shenendehowa, who upset undefeated Shaker on Friday night 17-14, and Christian Brothers Academy, coming off their victory over Guilderland in the AA semi-final 20-7 on Friday night. The two teams will meet at 7pm on Friday night at Shaker High School.

In the Class A championship game, Queensbury, who went through Averill Park 48-35 to earn their spot, takes on Burnt Hills, after they edged LaSalle 21-20, Saturday night at 7pm at Shenendehowa High School.

The other Friday night game will be the Class C championship game featuring undefeated Schuylerville, coming off of a 48-0 pounding of Voorheesville, takes on 7-1 Fonda-Fultonville following their 20-14 victory over Hoosick Falls in the semi-finals. Those teams will kick off at 7pm Friday at Lansingburgh High School.

Saturday's afternoon's final games will start with the Class D championship. Undefeated Greenwich, coming off of their 48-20 semi-final victory, marches into to Schuylerville High School to take on Stillwater, who was very tough against Warrensburg in their 31-12 victory last Saturday. That game kicks off at 1pm.

The Class B championship will be played at 3pm on Saturday at CBA with 8-2 Ravena-Coeymans-Selkirk, following their surprise turnaround Saturday against Glens Falls 35-28. Glens Falls pounded RCS the week prior 42-0. Well that didn't sit well and the results got turned around quickly for RCS. They will take on Gloversville, coming off their 15-14 victory over Schalmont to advance. It will certainly be a fun weekend for high school football in the Capital Region.

To prepare yourself for a potential incident, always keep your vet's phone number handy, along with an after-hours clinic you can call in an emergency. The ASPCA Animal Poison Control Center also has a hotline you can call at (888) 426-4435 for advice.

Even with all of these resources, however, the best cure for food poisoning is preventing it in the first place. To give you an idea of what human foods can be dangerous, Stacker has put together a slideshow of 30 common foods to avoid. Take a look to see if there are any that surprise you.

Read this article:
Section II HS Football Championships Are Set for This Week - WTMM 104.5 The Team - ESPN Radio

Tuscan Brands began in 2010 with Tuscan Kitchen in Salem, New Hampshire. Their brand continues to grow with the addition of locations in Burlington, Massachusetts, Boston, Massachusetts, and Portsmouth, New Hampshire. Joe Faro owner of the Tuscan brands believes strongly in giving back to the community. He serves a large family-style meal to veterans and a guest on Veterans Day.

Veterans and their guests can expect a full-scale traditional Italian feast according to a statement put out but Tuscan Brands. This includes Penne Bolognese, Roast Pork Tenderloin, Yukon gold mashed potatoes, and roasted carrots. Dessert will be fresh from the oven-baked cookie and some Italian dark roasted coffee. Joe Faro expects to feed over four thousand veterans and their guests this year. Since the inception of Tuscan brands, Joe Faro has served over fifteen thousand vets.

If you are a veteran in Salem, New Hampshire, Burlington, Massachusetts, Boston Massachusetts, or Portsmouth New Hampshire, you can register for the restaurant in your city by calling or online at this link http://www.tuscanbrands.com/veteransday. The meals will be served at the Tuscan Kitchen, Tuscan Sea Grill & Bar, and Toscana Italian Chop House and Wine Bar. What a great way to give back to the community and thank our vets. They are sure to enjoy a fresh, made from scratch Italian feast. The meals will be served from 11 am to 4 pm. If you are a veteran living in one of those cities, hop online and book your reservation.

Since we are talking about food...

To prepare yourself for a potential incident, always keep your vet's phone number handy, along with an after-hours clinic you can call in an emergency. The ASPCA Animal Poison Control Center also has a hotline you can call at (888) 426-4435 for advice.

Even with all of these resources, however, the best cure for food poisoning is preventing it in the first place. To give you an idea of what human foods can be dangerous, Stacker has put together a slideshow of 30 common foods to avoid. Take a look to see if there are any that surprise you.

These Are 45 Pictures Of What New Englanders Say Makes Them Smile

Read the rest here:
Tuscan Kitchen in New England Will Honor Veterans on Veterans Day - wokq.com

Dr Aparna Dhar, HOD-Medical Genetics and Genetic Counselling, CORE Diagnostics talks about the role of molecular testing in blood cancer treatment

Blood cancers, also called hematologic malignancies, are the cancers of the blood, bone marrow, and lymph nodes. It is due to uncontrolled blood cell production and altered function. These cancers can affect anyone, including children. Hematological malignancies account for 8% of new cancer diagnoses in India.

However, misinformation and lack of awareness about blood cancer and its types are the biggest challenges observed today among the Indian population. Due to lack of awareness, people arent aware that blood cancer can be managed, a patient can have a second chance at life with chemotherapy, targeted therapy, stem cell transplant etc.

And, with the availability of advanced and sophisticated molecular diagnostic methods, we have answers to questions regarding cancer diagnosis, prognosis, risk stratification and the best course of treatment.

Well briefly discuss the types of blood cancers, the known or likely genes causing blood cancers, and a range of in vitro molecular diagnostics laboratory testing methods to detect them and help guide treatment options.

Blood cancer can be categorised as:

Of all types of blood cancers, the three most common types that affect the Indian population are Lymphoma (starts in the lymphatic system), Leukemia (starts in the bone marrow) and Multiple Myeloma (starts in the bone marrow).

Lymphomas and leukemia affect adults and children both, but Myeloma is a relatively common condition which affects adults. Acute Myeloid Leukemia (AML) is the most common type of leukemia in adults and Acute Lymphoblastic Leukemia (ALL) accounts for 25% of all childhood cancers. It is the most common malignancy in children.

What causes blood cancer?

The specific causes of blood cancer are not yet known. However, there are certain factors that contribute to blood cancer:

Common symptoms to be on the lookout for are:

In most cases of blood cancer, the patient feels tired and weak. This is due to a decrease in the number of red blood cells in the blood which results in lack of blood.

Fever is a common symptom of cancer. The immunity becomes weak; thus, the patient often has a fever.

Prone to repeated infections. When leukemia cells develop in the body, then complaints of infection can be seen in the patients mouth, throat, skin, lungs, etc.

People who have cancer tend to have an abnormally low weight. If the body weight is reduced without any obvious cause, then it can be seen as the primary symptom of cancer.

Pain in bones and joints can be a symptom of not only arthritis but also blood cancer. As blood cancer is a disease in the bone marrow, large amounts can be seen around the bones and joints.

The abnormal formation of leukemia cells in the body prevents the bone marrow from producing healthy blood cells such as platelets. Due to its deficiency, more bleeding problems can be seen from the nose of the patient, during menstruation, gums, etc.

Testing

There are a plethora of tests offered to understand the molecular and genetic basis of blood cancers. These tests guide informed treatment- related decisions. A combination of various techniques, radiology (PET, CTscan etc.) and multiple biomarkers tested by different technologies can help shed light on a comprehensive understanding of the patients disease to the treating physician.

The diagnosis of AML is made using immunophenotyping and analysis of underlying genetic abnormalities using cytogenetics (for risk classification) and molecular testing. Analysis of FLT3, NPM1, and CEBPA genes are recommended as a minimum by international guidelines. Subtypes of AML, such as acute promyelocytic leukemia (APL), have specific molecular markers associated with them. Analysis of PML-RARA in APL is now standard of care.

CML is characterized by a specific chromosomal translocation (part of a chromosome fuses to part of another chromosome) of chromosomes 9 and 22 known as the Philadelphia chromosome. This characteristic chromosomal abnormality can be detected by cytogenetics, by FISH, or by PCR targeted at the BCR/ABL fusion gene. CML is treated using targeted drugs. These drugs are monitored using RT-PCR (molecular testing).

Diagnosis of CLL is made by examining smears of the peripheral blood and bone marrow, immunophenotyping and (IgVH) gene mutation status. Immunophenotyping of the patients cells plays a central role in the diagnosis of a patient with lymphoma. The immunophenotypic analysis will guide molecular test selection such as T-cell clonality analysis, IGVH analysis, or targeted FISH analysis.

Diagnosis of Multiple Myeloma is made by analysing the blood and urine sample for: M protein (electrophoresis), Quantitative immunoglobulins, Serum free light chains, serum albumin and serum beta-2 microglobulin (2-M), Lactase dehydrogenase (LDH). In addition a bone marrow biopsy/aspirate is used to test for immunohistochemistry, flow cytometry, cytogenetics (FISH) or minimal residual disease test.

Treatment of blood cancer

Treatment depends on the type of blood cancer, age, how fast the cancer is progressing, and whether the cancer has spread to other parts of the body.

Because treatments for blood cancer have vastly improved over the last several decades, many types of blood cancers are now highly treatable. Common treatments include the following:

Conclusion

There is a lack of awareness about blood cancer, especially among the rural population. Ignoring the symptoms at an early stage and/or delay in diagnosis leads to delay in seeking care. Every blood cancer patient who gets diagnosed early and has access to treatment is a victory in itself.

The challenge of the next decade now is to develop indigenous methods of delivering CAR-T cells, immunotherapies, and molecularly targeted therapies, and using them in the right combination and sequence in order to extend the quality and quantity of life meaningfully for

A minimum of 30% of the future cancer burden can be easily prevented, if necessary, measures are taken in the early stages. From tobacco sales and consumption control to expansion and equal distribution of medical facilities, awareness & education programs about risks, prevention, and bone marrow donation, a lot can be done to minimise the rise of blood cancer in India.

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Molecular testing in guiding blood cancer treatment - Express Healthcare

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FT596 Oral and FT516 Poster Presentations to Highlight Updated Clinical Data for Relapsed / Refractory Lymphoma on Monday, December 13

Company to Host Virtual Investor Event on Tuesday, December 14

SAN DIEGO, Nov. 04, 2021 (GLOBE NEWSWIRE) -- Fate Therapeutics, Inc. (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for patients with cancer, today announced that three oral and five poster presentations for the Companys induced pluripotent stem cell (iPSC) product platform were accepted for presentation at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition being held from December 11-14, 2021. The Company also plans to host a virtual investor event on Tuesday, December 14.

The oral presentations will include updated Phase 1 clinical data of FT596, the Companys universal, off-the-shelf natural killer (NK) cell cancer immunotherapy derived from a clonal master iPSC line engineered with three anti-tumor functional modalities: a proprietary chimeric antigen receptor (CAR) optimized for NK cell biology that targets B-cell antigen CD19; a novel high-affinity, non-cleavable CD16 (hnCD16) Fc receptor, which has been modified to prevent its down-regulation and to enhance its binding to tumor-targeting antibodies; and an IL-15 receptor fusion (IL-15RF) that augments NK cell activity. The Company previously reported interim Phase 1 clinical data of FT596 as monotherapy and in combination with rituximab for the treatment of relapsed / refractory B-cell lymphoma. As of the data cutoff date of June 25, 2021, in the second and third dose cohorts (90 million cells and 300 million cells, respectively) of the single-dose monotherapy and combination regimens, 10 of 14 patients (71%) achieved an objective response, including seven patients (50%) that achieved a complete response, on Day 29 as assessed by PET-CT scan per Lugano 2014 criteria. Treatment with FT596 was well tolerated, with two reported low-grade adverse events (one Grade 1, one Grade 2) of cytokine release syndrome (CRS) and no reported adverse events of immune effector cell-associated neurotoxicity syndrome (ICANS) or graft-versus-host disease (GVHD).

The poster presentations will include updated Phase 1 clinical data of FT516, the Companys universal, off-the-shelf NK cell cancer immunotherapy derived from a clonal master iPSC line engineered to express a novel hnCD16 Fc receptor. The Company previously reported interim Phase 1 clinical data of FT516 in combination with rituximab for the treatment of relapsed / refractory B-cell lymphoma. As of the data cutoff date of July 7, 2021, in the second and third multi-dose cohorts (90 million cells per dose and 300 million cells per dose, respectively), eight of 11 patients (73%) achieved an objective response, including six patients (55%) that achieved a complete response, on Day 29 of the second FT516 treatment cycle as assessed by PET-CT scan per Lugano 2014 criteria. Five of the 11 patients (45%) maintained their response without further therapeutic intervention, including four patients that remained in complete response (4.6-9.5 months) and one patient that remained in partial response (6.1 months). The multi-dose, multi-cycle treatment regimen was well tolerated, and no adverse events of CRS, ICANS, or GVHD were reported.

Additional presentations will include an oral presentation describing preclinical and clinical translational data of FT596; a poster presentation describing the making of the clonal engineered master iPSC line for FT819, which is created from a single iPSC that has a novel CD19-targeted 1XX CAR construct integrated into the T-cell receptor alpha constant (TRAC) locus; a poster presentation describing the preclinical activity of a novel multiplexed-engineered, dual CAR NK cell product candidate targeting B-cell maturation antigen (BCMA) and the alpha-3 domain of MICA/B in models of multiple myeloma; and a poster presentation describing the preclinical activity of multiplexed-engineered, iPSC-derived T cells incorporating three distinct tumor-targeting modalities (CAR, TCR and hnCD16).

Oral Presentations

Poster Presentations

The accepted abstracts are available online through the ASH conference website (www.hematology.org/Annual-Meeting/Abstracts/).

About Fate Therapeutics iPSC Product PlatformThe Companys proprietary induced pluripotent stem cell (iPSC) product platform enables mass production of off-the-shelf, engineered, homogeneous cell products that can be administered with multiple doses to deliver more effective pharmacologic activity, including in combination with other cancer treatments. Human iPSCs possess the unique dual properties of unlimited self-renewal and differentiation potential into all cell types of the body. The Companys first-of-kind approach involves engineering human iPSCs in a one-time genetic modification event and selecting a single engineered iPSC for maintenance as a clonal master iPSC line. Analogous to master cell lines used to manufacture biopharmaceutical drug products such as monoclonal antibodies, clonal master iPSC lines are a renewable source for manufacturing cell therapy products which are well-defined and uniform in composition, can be mass produced at significant scale in a cost-effective manner, and can be delivered off-the-shelf for patient treatment. As a result, the Companys platform is uniquely capable of overcoming numerous limitations associated with the production of cell therapies using patient- or donor-sourced cells, which is logistically complex and expensive and is subject to batch-to-batch and cell-to-cell variability that can affect clinical safety and efficacy. Fate Therapeutics iPSC product platform is supported by an intellectual property portfolio of over 350 issued patents and 150 pending patent applications.

About FT516FT516 is an investigational, universal, off-the-shelf natural killer (NK) cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line engineered to express a novel high-affinity 158V, non-cleavable CD16 (hnCD16) Fc receptor, which has been modified to prevent its down-regulation and to enhance its binding to tumor-targeting antibodies. CD16 mediates antibody-dependent cellular cytotoxicity (ADCC), a potent anti-tumor mechanism by which NK cells recognize, bind and kill antibody-coated cancer cells. ADCC is dependent on NK cells maintaining stable and effective expression of CD16, which has been shown to undergo considerable down-regulation in cancer patients. In addition, CD16 occurs in two variants, 158V or 158F, that elicit high or low binding affinity, respectively, to the Fc domain of IgG1 antibodies. Numerous clinical studies with FDA-approved tumor-targeting antibodies, including rituximab, trastuzumab and cetuximab, have demonstrated that patients homozygous for the 158V variant, which is present in only about 15% of patients, have improved clinical outcomes. FT516 is being investigated in a multi-dose Phase 1 clinical trial as a monotherapy for the treatment of acute myeloid leukemia and in combination with CD20-targeted monoclonal antibodies for the treatment of advanced B-cell lymphoma (NCT04023071). Additionally, FT516 is being investigated in a multi-dose Phase 1 clinical trial in combination with avelumab for the treatment of advanced solid tumors resistant to anti-PDL1 checkpoint inhibitor therapy (NCT04551885).

About FT596FT596 is an investigational, universal, off-the-shelf natural killer (NK) cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line engineered with three anti-tumor functional modalities: a proprietary chimeric antigen receptor (CAR) optimized for NK cell biology that targets B-cell antigen CD19; a novel high-affinity 158V, non-cleavable CD16 (hnCD16) Fc receptor, which has been modified to prevent its down-regulation and to enhance its binding to tumor-targeting antibodies; and an IL-15 receptor fusion (IL-15RF) that augments NK cell activity. In preclinical studies of FT596, the Company has demonstrated that dual activation of the CAR19 and hnCD16 targeting receptors enhances cytotoxic activity, indicating that multi-antigen engagement may elicit a deeper and more durable response. Additionally, in a humanized mouse model of lymphoma, FT596 in combination with the anti-CD20 monoclonal antibody rituximab showed enhanced killing of tumor cells in vivo as compared to rituximab alone. FT596 is being investigated in a multi-center Phase 1 clinical trial for the treatment of relapsed / refractory B-cell lymphoma as a monotherapy and in combination with rituximab, and for the treatment of relapsed / refractory chronic lymphocytic leukemia (CLL) as a monotherapy and in combination with obinutuzumab (NCT04245722).

About FT819FT819 is an investigational, universal, off-the-shelf, T-cell receptor (TCR)-less CD19 chimeric antigen receptor (CAR) T-cell cancer immunotherapy derived from a clonal master induced pluripotent stem cell (iPSC) line, which is engineered with the following features designed to improve the safety and efficacy of CAR19 T-cell therapy: a novel 1XX CAR signaling domain, which has been shown to extend T-cell effector function without eliciting exhaustion; integration of the CAR19 transgene directly into the T-cell receptor alpha constant (TRAC) locus, which has been shown to promote uniform CAR19 expression and enhanced T-cell potency; and complete bi-allelic disruption of TCR expression for the prevention of graft-versus-host disease. FT819 demonstrated antigen-specific cytolytic activity in vitro against CD19-expressing leukemia and lymphoma cell lines comparable to that of primary CAR T cells, and persisted and maintained tumor clearance in the bone marrow in an in vivo disseminated xenograft model of lymphoblastic leukemia (Valamehr et al. 2020). FT819 is being investigated in a multi-center Phase 1 clinical trial for the treatment of relapsed / refractory B-cell malignancies, including B-cell lymphoma, chronic lymphocytic leukemia, and acute lymphoblastic leukemia (NCT04629729).

About Fate Therapeutics, Inc.Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of first-in-class cellular immunotherapies for patients with cancer. The Company has established a leadership position in the clinical development and manufacture of universal, off-the-shelf cell products using its proprietary induced pluripotent stem cell (iPSC) product platform. The Companys immuno-oncology pipeline includes off-the-shelf, iPSC-derived natural killer (NK) cell and T-cell product candidates, which are designed to synergize with well-established cancer therapies, including immune checkpoint inhibitors and monoclonal antibodies, and to target tumor-associated antigens using chimeric antigen receptors (CARs). Fate Therapeutics is headquartered in San Diego, CA. For more information, please visit http://www.fatetherapeutics.com.

Forward-Looking StatementsThis release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995 including statements regarding the Companys clinical studies and preclinical research and development programs, its ongoing and planned clinical studies, and the safety and therapeutic potential of the Companys product candidates. These and any other forward-looking statements in this release are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risk that the Companys product candidates may not demonstrate the requisite safety or efficacy to achieve regulatory approval or to warrant further development, the risk that results observed in prior studies of the Companys product candidates, including preclinical studies and clinical trials of any of its product candidates, will not be observed in ongoing or future studies involving these product candidates, the risk of a delay or difficulties in the manufacturing of the Companys product candidates or in the initiation of, or enrollment of patients in, any clinical studies, the risk that the Company may cease or delay preclinical or clinical development of any of its product candidates for a variety of reasons (including requirements that may be imposed by regulatory authorities on the initiation or conduct of clinical trials, the amount and type of data to be generated, or otherwise to support regulatory approval, difficulties or delays in patient enrollment and continuation in the Companys ongoing and planned clinical trials, difficulties in manufacturing or supplying the Companys product candidates for clinical testing, and any adverse events or other negative results that may be observed during preclinical or clinical development), and the risk that its product candidates may not produce therapeutic benefits or may cause other unanticipated adverse effects. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the Companys actual results to differ from those contained in the forward-looking statements, see the risks and uncertainties detailed in the Companys periodic filings with the Securities and Exchange Commission, including but not limited to the Companys most recently filed periodic report, and from time to time in the Companys press releases and other investor communications.Fate Therapeutics is providing the information in this release as of this date and does not undertake any obligation to update any forward-looking statements contained in this release as a result of new information, future events or otherwise.

Contact:Christina TartagliaStern Investor Relations, Inc.212.362.1200christina@sternir.com

Continued here:
Fate Therapeutics Announces Eight Presentations at the 2021 ASH Annual Meeting - StreetInsider.com

BOTHELL, Wash.--(BUSINESS WIRE)--Nov 4, 2021--

Seagen Inc. (Nasdaq:SGEN) today announced that new data for ADCETRIS (brentuximab vedotin), including five oral presentations, will be featured at the upcoming 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, taking place December 11-14, 2021. Data presentations will include updated safety and efficacy results from clinical trials examining the potential of ADCETRIS with novel combinations in patients with advanced stage classical Hodgkin lymphoma (HL), in patients with newly diagnosed CD30-expressing peripheral T-cell lymphoma (PTCL) and in patients with other histologies.

We look forward to sharing new data for the continued development of ADCETRIS in combination with other therapies across patient populations, said Roger Dansey, M.D., Chief Medical Officer at Seagen. Additionally, initial results will be presented from our SEA-BCMA program in patients with relapsed/refractory multiple myeloma.

ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of classical HL and expressed on the surface of several types of PTCL. ADCETRIS is approved in more than 75 countries for relapsed or refractory HL and systemic anaplastic large cell lymphoma (sALCL).

Presentations of Company-Sponsored ADCETRIS Trials:

Abstract Title

Abstract #

Presentation

Lead Author

The ECHELON-2 Trial: 5-Year Exploratory Subgroup Analyses of a Randomized, Double-Blind, Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) vs CHOP in Frontline Treatment of Pts with CD30-Positive Peripheral T-Cell Lymphoma

#135

Oral presentation /Saturday, Dec. 11,12:00 1:30 p.m. EST

S. Horwitz

Classical Hodgkin Lymphoma: Real-World Observations from Physicians, Patients, and Caregivers on the Disease and Its Treatment (CONNECT): Observations of Physicians on Treatment and Interim PET-Adapted Regimens

#1390

Poster presentation /Saturday, Dec. 11,5:30 7:30 p.m. EST

S. Parsons

Classical Hodgkin Lymphoma: Real-World Observations from Physicians, Patients, and Caregivers on the Disease and Its Treatment (CONNECT)a Cross-Sectional Survey of Patients with Stage III or IV Classical Hodgkin Lymphoma Compared By Age

#1966

Poster presentation /Saturday, Dec. 11,5:30 7:30 p.m. EST

D. Flora

Pharmacodynamics of SEA-BCMA, a Nonfucosylated Antibody Targeting BCMA, in Patients with Relapsed/Refractory Multiple Myeloma

#1197

Poster presentation /Saturday, Dec. 11,5:30 7:30 p.m. EST

D. Taft

Brentuximab vedotin, nivolumab, doxorubicin, and dacarbazine (AN+AD) for advanced stage classic Hodgkin lymphoma: preliminary results from the single-arm phase 2 study (SGN35-027 Part B)

#2454

Poster presentation /Sunday, Dec. 12,6:00 8:00 p.m. EST

H. Lee

An Oncology Simulation Model to Estimate 10-Year Progression-Free Survival and Overall Survival Based on the 5-Year Update from the Echelon-2 Trial in Frontline Patients with Peripheral T-Cell Lymphoma: A United States Perspective

#2440

Poster presentation /Sunday, Dec. 12,6:00 8:00 p.m. EST

T. Phillips

Classical Hodgkin Lymphoma: Real-World Observations from Physicians, Patients, and Caregivers on the Disease and Its Treatment (CONNECT): Physician First-Line Treatment Preferences for Stage III or IV Classical Hodgkin Lymphoma

#2467

Poster presentation /Sunday, Dec. 12,6:00 8:00 p.m. EST

A. Evens

An Oncology Simulation Model to Estimate 10-Year Progression-Free Survival and Overall Survival Based on the 5-Year Update from the Echelon-2 Trial in Frontline Patients with Peripheral T-Cell Lymphoma: A United States Perspective

#2466

Poster presentation /Sunday, Dec. 12,6:00 8:00 p.m. EST

J. Burke

SEA-BCMA, an investigational nonfucosylated monoclonal antibody: interim results of a phase 1 study in relapsed/refractory multiple myeloma patients (SGNBCMA-001)

#2740

Poster presentation /Sunday, Dec. 12,6:00 8:00 p.m. EST

J. Hoffman

Trials-In-Progress

Brentuximab Vedotin in Combination with Nivolumab, Doxorubicin, and Dacarbazine in Newly Diagnosed Patients with Advanced Stage Hodgkin Lymphoma (SGN35-027, Trial in Progress)

#1369

Poster presentation /Saturday, Dec. 11,5:30 7:30 p.m. EST

I. Flinn

Brentuximab Vedotin in Combination with Lenalidomide and Rituximab in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (ECHELON-3, Trial in Progress)

#3564

Poster presentation /Monday, Dec. 13,6:00 8:00 p.m. EST

N. Bartlett

Frontline Brentuximab Vedotin Plus Cyclophosphamide, Doxorubicin and Prednisone in Patients With Peripheral T Cell Lymphoma With Less Than 10% CD30 Expression (SGN35 032, Trial in Progress)

#1401

Poster presentation /Saturday, Dec. 11,5:30 7:30 p.m. EST

D. Jagadeesh

Presentations of Investigator-Sponsored and Cooperative Group ADCETRIS Trials:

Abstract Title

Abstract #

Presentation

Lead Author

Brentuximab vedotin Plus Cyclophosphamide, Doxorubicin, Etoposide, and Prednisone (CHEP-BV) Followed by BV Consolidation in Patients with CD30-Expressing Peripheral T-cell Lymphomas

#133

Oral presentation /Saturday, Dec. 11,12:00 1:30 p.m. EST

A. Herrera

The Eatl-001 Trial: Results of a Phase 2 Study of Brentuximab vedotin and CHP Followed By Consolidation with High-Dose Therapy - Autologous Stem-Cell Transplantation (HDTASCT) in the Frontline Treatment of Patients with Enteropathy-Associated T-Cell Lymphoma

#136

Oral presentation /Saturday, Dec. 11,12:00 1:30 p.m. EST

D. Sibon

Interim results of a multicenter pilot study evaluating brentuximab vedotin with cyclophosphamide, doxorubicin, etoposide, and prednisone (BV-CHEP) for the treatment of aggressive adult T-cell leukemia/lymphoma

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Seagen to Highlight Multiple ADCETRIS (brentuximab vedotin) Data Presentations at the Upcoming 2021 American Society of Hematology (ASH) Annual...