An analysis report published by DataIntelo is an in-depth study and detailed information regarding the market size, market performance and market dynamics of the Canine Stem Cell Therapy. The report offers a robust assessment of the Global Canine Stem Cell Therapy Market to understand the current trend of the market and deduces the expected market trend for the Canine Stem Cell Therapy market for the forecast period. Providing a concrete assessment of the potential impact of the ongoing COVID-19 in the next coming years, the report covers key strategies and plans prepared by the major players to ensure their presence intact in the global competition. With the availability of this comprehensive report, the clients can easily make an informed decision about their business investments in the market.

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This detailed report also highlights key insights on the factors that drive the growth of the market as well key challenges that are expected to hamper the market growth in the forecast period. Keeping a view to provide a holistic market view, the report describes the market components such as product types and end users in details with explaining which component is expected to expand significantly and which region is emerging as the key potential destination of the Canine Stem Cell Therapy market. Moreover, it provides a critical assessment of the emerging competitive landscape of the manufacturers as the demand for the Canine Stem Cell Therapy is projected to increase substantially across the different regions.

The report, published by DataIntelo, is the most reliable information because it consists of a concrete research methodology focusing on primary as well as secondary sources. The report is prepared by relying on primary source including interviews of the company executives and representatives and accessing official documents, websites, and press release of the companies. The DataIntelos report is widely known for its accuracy and factual figures as it consists of a concise graphical representations, tables, and figures which displays a clear picture of the developments of the products and its market performance over the last few years.

Furthermore, the scope of the growth potential, revenue growth, product range, and pricing factors related to the Canine Stem Cell Therapy market are thoroughly assessed in the report in a view to entail a broader picture of the market.

Key companies that are covered in this report:

VETSTEM BIOPHARMACell Therapy SciencesRegeneusAratana TherapeuticsMedivet BiologicsOkyanosVetbiologicsVetMatrixMagellan Stem CellsANIMAL CELL THERAPIESStemcellvet

*Note: Additional companies can be included on request

The report covers a detailed performance of some of the key players and analysis of major players in the industry, segments, application and regions. Moreover, the report also takes into account the governments policies in the evaluation of the market behavior to illustrate the potential opportunities and challenges of the market in each region. The report also covers the recent agreements including merger and acquisition, partnership or joint venture and latest developments of the manufacturers to sustain in the global competition of the Canine Stem Cell Therapy market.

By Application:

Veterinary HospitalsVeterinary ClinicsVeterinary Research Institutes

By Type:

Allogeneic Stem CellsAutologous Stem cells

You can also go for a yearly subscription of all the updates on Canine Stem Cell Therapy market.

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According to the report, the Canine Stem Cell Therapy market is projected to reach a value of USDXX by the end of 2027 and grow at a CAGR of XX% through the forecast period (2020-2027). The report covers the performance of the Canine Stem Cell Therapy in regions, North America, Latin America, Europe, Asia Pacific, and Middle East & Africa by focusing some key countries in the respective regions. As per the clients requirements, this report can be customized and available in a separate report for the specific region and countries.

The following is the TOC of the report:

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Canine Stem Cell Therapy Market Overview

Canine Stem Cell Therapy Supply Chain Analysis

Canine Stem Cell Therapy Pricing Analysis

Global Canine Stem Cell Therapy Market Analysis and Forecast by Type

Global Canine Stem Cell Therapy Market Analysis and Forecast by Application

Global Canine Stem Cell Therapy Market Analysis and Forecast by Sales Channel

Global Canine Stem Cell Therapy Market Analysis and Forecast by Region

North America Canine Stem Cell Therapy Market Analysis and Forecast

Latin America Canine Stem Cell Therapy Market Analysis and Forecast

Europe Canine Stem Cell Therapy Market Analysis and Forecast

Asia Pacific Canine Stem Cell Therapy Market Analysis and Forecast

Middle East & Africa Canine Stem Cell Therapy Market Analysis and Forecast

Competition Landscape

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Impact Of Covid-19 On Canine Stem Cell Therapy Market Is To Witness Significant Growth Between 2020-2027 With Leading Players VETSTEM BIOPHARMA, Cell...

Earlier this year, as transmission of SARS-CoV-2, the virus behind the COVID-19 pandemic, started to pick up speed, researchers around the world hurried to find model systems that could provide insight into disease spread, host immune responses, and possible treatments.

When the pandemic first started, nobody really knew what was going to be the best model, says Amanda Martinot, a veterinary pathologist at Tufts Cummings School of Veterinary Medicine.

The most widely available candidates were mice, which are easily housed and so well-researched that there are tons of tools available for studying nearly every aspect of their biology. But as researchers suspected, based on previous incompatibility of mice and other coronaviruses, the animals present challenges when it comes to studying SARS-CoV-2. The virus uses a human receptor called ACE2 to get into cells, but mouse ACE2 is different enough that the virus doesnt readily bind it.

Scientists have overcome the issue using two separate strategies: generating transgenic animals that express the human receptor and modifying the SARS-CoV-2 virus to make it better able to bind mouse ACE2.

Even with the success of those approaches, investigators have also been on the lookout for other options. Ferrets, for instance, are useful for studying viral transmission and viral replication in the upper respiratory tract and have been used by several groups for SARS-CoV-2 experiments. Some researchers have also turned to hamsters, which have been used in the past to study other viruses, including the coronaviruses responsible for severe acute respiratory syndrome and Middle East respiratory syndrome.

Hamsters are known in virology for their permissiveness to all kinds of viral infection really, and, as a rule of thumb, I would say if something doesnt work in a mouse, you may as well try a hamster, says Jakob Trimpert, a postdoc at the Free University of Berlin. And if youre lucky, it works there. Along with collaborators, hes been using several species of hamsters to study SARS-CoV-2 infections and potential therapeutics.

The hamster ACE2 receptor is compatible with SARS-CoV-2, and the animals develop clear clinical indicators of disease, he explains. For instance, Syrian hamsters(Mesocricetus auratus), one of the hamster species most commonly used in virus research worldwide, get mild SARS-CoV-2 infections, but their main symptomweight lossis reproducible and possible to measure. These animals also have severe pneumonia that is detectable via lung pathology. Trimpert and his colleagues used both transcriptomics and proteomics to evaluate the animals immune responses to SARS-CoV-2 in a study they published on July 20.

Many alveolar air spaces (white) are collapsed during a SARS-CoV-2 lung infection in a Syrian hamster (right). They are not collapsed in an uninfected hamsters lung (left).

Amanda martinot, tufts cummings school of veterinary medicine

Hamsters have been the best model so far for showing us any clinical disease, says Martinot. They develop weight loss, and they develop a fulminant pneumonia where its affecting sometimes over fifty percent of their lung, she adds. They also will recover if given time, but the pathology we feel is more representative of what you might see in humans. Martinot, Dan Barouch, who directs the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, and other collaborators recently published a study showing that a SARS-CoV-2 vaccine protected against weight loss and pneumonia in Syrian hamsters.

This species, also known as the golden Syrian hamster, has some drawbacks, too, Trimpert says. Theyre big, for one, weighing in at 150160 grams fully grown, in contrast to adult mice, which tip the scales at about 3035 grams. Syrian hamsters are also aggressive toward each other and sometimes the people taking care of them. Their size and aggression mean that they often have to be housed alone in larger cages, which makes them more expensive to keep.

The biggest issues, according to Trimpert, are the poor quality of the sequenced genomemany genes are just missingand the lack of molecular tools that work in hamsters. To circumvent these problems, Trimpert and his colleagues are resequencing and annotating the Syrian hamster genome.

Because the weight loss in Syrian hamsterstheir only easily observable clinical symptomis quite mild, its also a drawback, particularly when testing therapies or vaccines, Trimpert tells The Scientist. If you need thirty hamsters in order to get statistical significance . . . that is a huge practical problem.

The researchers are skirting this issue by beginning work with another species, Roborovski dwarf hamsters (Phodopus roborovskii), which are smaller than mice and less aggressive than Syrian hamsters. The dwarf hamsters also get much sicker than their larger relatives following SARS-CoV-2 infection, developing massive blood clots in the lungs, which are often present in severe cases of COVID-19 in people as well. Most of these hamsters eventually die of the complications of the infection, which, according to Trimpert, indicates that they might be a good model of severe disease in humans.

A human intestinal organoid (with nuclei labeled in blue and cell shape outlined in green) infected with SARS-CoV-2 (labeled in red)

Joep Beumer

Getting a better picture of what is happening in people is a common goal. Eric Song, an MD/PhD student in Akiko Iwasakis lab at Yale School of Medicine, wanted to determine what effect SARS-CoV-2 was having on the brain. He and his colleagues used a humanized mouse model, in which a promoter drives the expression of human ACE2 in epithelial cells, in a study released as a preprint earlier this year. They found that SARS-CoV-2 could infect the central nervous system in the mice, but it still wasnt clear whether those findings translated to human patients.

To probe that question, the researchers turned to brain organoidscultured, miniature organs that resemble the developing brain and contain neuronal and glial cell types derived from human induced pluripotent stem cells (iPSCs). Not only did SARS-CoV-2 infect the organoids, infection also appeared to cause cell death, a finding corroborated by another study in brain organoids published by separate group September 23. Song and his colleagues also found antibodies against SARS-CoV-2 in the cerebrospinal fluid of people with COVID-19 and evidence of SARS-CoV-2 infection in the post-mortem brains of COVID-19 patients.

The team used three complementary methods to account for the limitations of each, Song tells The Scientist.There is room for all the different models that are in play, he adds. With human samples, you can only take really a snapshot of the sickest patients because thats the only time you will be getting a post-mortem sample, but combined with the mouse and the organoid model, youre able to study [the] kinetics and the dynamic process of viral invasion. Things like organoids really help us access tissues that we would not otherwise have access to.

Immunologist and developmental biologist Hans Clevers of Utrecht University in the Netherlands and colleagues are leveraging that access with gut organoids. Rather than deriving the organoids from iPSCs, though, they use multipotent stem cells taken from any adult epithelial tissue. In some ways the strategy is more limited: gut epithelial cells can only make mini guts, for instance, in contrast to iPSC-derived organoids, which can become lots of different tissues. On the other hand, they grow forever, Clevers says. iPSC-based organoids, you make them and then you have to use them for an experiment because they stop growing the moment you start specifying them.

His group published a study on July 3 investigating whether or not SARS-CoV-2 can target the gut, a hypothesis based on the expression of ACE2 in the intestinal lining and the gastrointestinal symptoms that many COVID-19 patients experience. Their work in human small intestinal organoids confirmed that the virus does enter the cells of the intestinal lining, replicate, and cause changes in gene expression.

Now, Clevers and his colleagues are using organoids to test possible COVID-19 therapeutics. Chloroquine is an example of a drug that looked promising for blocking SARS-CoV-2 infection when researchers tried it in conventional cell culturein that case, cells derived from African green monkey kidneys and grown in one layer on a dish, he says. But, as theyve shown in a new study thats been submitted for peer review, in the gut organoid model chloroquine is ineffective against SARS-CoV-2, just as it is in patients. According to Clevers, this latest finding indicates that an extra screening step in organoids following the identification of a promising drug in a traditional cell culture system could provide another layer of information before moving into preclinical animal models or the clinic.

Cell lines are cheap, they grow fast, and most robotic strategies for screening have been designed for cells growing in two dimensions, Clevers says. There are multiple efforts now around the world to come up with the machines to do similar high throughput screens with 3D. With the organoids, its a little bit more complex to analyze because theyre not flat, he explains, but the type of organoids they generate in his lab grow quickly. He predicts that organoids will come to be used more widely because their physiology recapitulates that of humans so well, but that theyll never replace animals.

Along with hamsters, nonhuman primates are one of the main models that researchers studying COVID-19 therapeutics use. SARS-CoV-2 readily infects primates, such as macaques, due to the compatibility of their ACE2 receptor, but they do not show disease symptoms, says Martinot. The nonhuman primate experience of COVID-19 seems to be most similar to the mildly symptomatic cases of most people who are infected, she adds. They develop regions of pathology in their lungs that are detectable with a microscope, but its not enough to make them sick, and observing that kind of disease in a person is unlikely because these animals are euthanized early in infection to allow researchers to track any changes.

It would be nice to have a primate model of severe disease, says Barouch. Nobody has been able to develop one so far, but models are always in development.

And symptom presentation isnt everything. These animals are harder to access and harder to house than rodents, but they are a wonderful model for vaccine research and for evaluating . . . the adaptive immune response to COVID-19, Martinot says, at least in part because there are so many existing tools researchers can leverage. Reagents that are available for evaluating the immune response [in people] work in monkeys, and so we can very carefully monitor the nonhuman primate for the development of antibodies, cytokine responses, and T-cell responses, she adds.

You always want to pick your best model for your specific question, Martinot tells The Scientist. But depending on what kind of question youre asking, or what kind of drug youre testing, you really have to choose the model that best fits your ability to answer those questions in a very accurate and reproducible way.

The World Health Organizations Research & Development Blueprint Team has been working on this since February. The team reviews progress and coordinates efforts on animal models of COVID-19 with the primary goal of advancing the development of COVID-19 therapeutics and vaccines. On September 23, some group members and a handful of other researchers published a review detailing the work thats been done to model SARS-CoV-2 infections in animalsparticularly, mice, hamsters, ferrets, and nonhuman primatesand highlighting how findings in animals correspond to disease progression in people.

The development and use of these models is not a linear process, and theyre under constant revision, says Barouch, who is part of the WHO working group. When there is human data, then that allows back validation or refinement of the model . . . so there has to be a continuous feedback from models to clinical trials and back.

In things that are so new, like SARS-CoV-2, it may well be that there is more than one useful animal model, Trimpert says. We should be open and flexible, especially in emergency situations like this.

Go here to read the rest:
The Many Model Systems of COVID-19 - The Scientist

AllTheResearch, now has a research study on the Canine Stem Cell Therapy market which delivers a precise summary of the industry estimates, SWOT analysis, industry size, profit estimation and regional outlook of the business. The report offers a concise estimation of future growth prospects and obstacles awaiting market players of this industry, while further examining their existing competitive settings and business strategies.

The global Canine Stem Cell Therapy market was valued at US$ 118.5 Mn in 2018 year and is expected to reach US$ 240.7 Mn in 2026, growing at a CAGR of 9.3% during the forecast period.

Key Questions Answered in the Report:

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The research report on Canine Stem Cell Therapy market, covering the COVID-19 impact, provides a comparative analysis of the historical data with the current market scenario to unveil the growth projections for the industry over the analysis period. As per the study, the Canine Stem Cell Therapy market is expected to garner substantial returns and showcase a healthy growth rate throughout the forecast duration.

The Major Players Covered in Canine Stem Cell Therapy Market Study are:

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Major Segments Covered in Canine Stem Cell Therapy Market Reports are based on types and Applications as Follows:

Based on Types Canine Stem Cell Therapy Market Segmentation:

Based on Applications Canine Stem Cell Therapy Market Segmentation:

COVID-19 Impact on Canine Stem Cell Therapy Market:

The outbreak of COVID-19 has brought along a global recession, which has impacted several industries. Along with this impact COVID Pandemic has also generated few new business opportunities for Canine Stem Cell Therapy Market. Overall competitive landscape and market dynamics of Canine Stem Cell Therapy has been disrupted due to this pandemic. All these disruptions and impacts has been analysed quantifiably in this report, which is backed by market trends, events and revenue shift analysis. COVID impact analysis also covers strategic adjustments for Tier 1, 2 and 3 players of Canine Stem Cell Therapy Market.

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Canine Stem Cell Therapy Market Size, Share Analysis by Manufacturers, Regions, Type and Application to 2026 - PRnews Leader

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segment by Type, the product can be split intoAllogeneic Stem CellsAutologous Stem cells

Market segment by Application, split intoVeterinary HospitalsVeterinary ClinicsVeterinary Research Institutes

Based on regional and country-level analysis, the Canine Stem Cell Therapy market has been segmented as follows:North AmericaUnited StatesCanadaEuropeGermanyFranceU.K.ItalyRussiaNordicRest of EuropeAsia-PacificChinaJapanSouth KoreaSoutheast AsiaIndiaAustraliaRest of Asia-PacificLatin AmericaMexicoBrazilMiddle East & AfricaTurkeySaudi ArabiaUAERest of Middle East & Africa

Competitive Landscape

Key players of the global Canned Vegetable Juice market are profiled on the basis of various factors, which include recent developments, business strategies, financial strength, weaknesses, and main business. The Canned Vegetable Juice report offers a special assessment of top strategic moves of leading players such as merger and acquisition, collaboration, new product launch, and partnership.

In the competitive analysis section of the report, leading as well as prominent players of the global Canine Stem Cell Therapy market are broadly studied on the basis of key factors. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on price and revenue (global level) by player for the period 2015-2020.The key players covered in this studyVETSTEM BIOPHARMACell Therapy SciencesRegeneusAratana TherapeuticsMedivet BiologicsOkyanosVetbiologicsVetMatrixMagellan Stem CellsANIMAL CELL THERAPIESStemcellvet

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Canned Vegetable Juice Market: Global Opportunities, Regional Overview, Top Leaders, Size, Revenue and Forecast up to 2025 - PRnews Leader

Global Stem Cell Characterization and Analysis Tool Market Forecast to 2025 is a new research released at Market Study Report and provides information about industry Top Key Players, Countries, Type and Application. This Stem Cell Characterization and Analysis Tool report also states Company Profile, sales, Stem Cell Characterization and Analysis Tool Market revenue and price, market share, market growth and gross margin by regions, Strategic recommendations for the new entrants, Market forecasts for a minimum of five years of all the mentioned segments, sub segments and the regional markets.

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The document measures the key factors which are positively influencing the industry landscape in terms of market growth as well as sales generation. Furthermore, it offers comprehensive analysis of the major market trends and their impact on the overall business outlook.

Key aspects of Stem Cell Characterization and Analysis Tool market report:

Regional analysis of Stem Cell Characterization and Analysis Tool market:

Stem Cell Characterization and Analysis Tool Market Segmentation: Americas, APAC, Europe, Middle East & Africa

An overview of the regional landscape of Stem Cell Characterization and Analysis Tool market:

Product landscape and application scope of Stem Cell Characterization and Analysis Tool market:

Product landscape:

Product types: Services, Software, Instruments, Accessories, Consumables and Reagent and Assay Kits

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Application Landscape:

Application segmentation: Neurological Disorders, Orthopedic Treatments, Oncology Disorders, Diabetes, Other Therapeutic Applications and Drug Development and Discovery Embryonic Stem Cells Research

Insights provided by the document:

Additional details specified in the document:

Competitive arena of the Stem Cell Characterization and Analysis Tool market:

Major players in the Stem Cell Characterization and Analysis Tool market: Osiris Therapeutics, Inc., Caladrius Biosciences, Inc., Astellas Pharma Inc., TEMCELL Technologies Inc., U.S. Stem Cell, Inc., Cytori Therapeutics, Inc., BioTime Inc., BrainStorm Cell Therapeutics Inc. and Cellular Engineering Technologies Inc

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How an Imaging Test Predicts Treatment Response

If youve already gone through a round of treatment for diffuse large B-cell lymphoma and it didnt work, or your cancer came back after treatment, your doctor might start talking to you about having an autologous stem cell transplant. This therapy involves getting high doses of chemotherapy to get rid of your cancer cells, followed by an infusion of stem cells taken from your blood or bone marrow before treatment, to replenish your bodys supply of healthy blood cells.

Related: What is Autologous Stem Cell Transplant?

A stem cell transplant can be a pretty grueling treatment that involves getting very high doses of chemotherapy, spending three to four weeks in the hospital, and enduring side effects like nausea, vomiting, mouth pain, infections, bleeding, and lung inflammation. And after all of that, you still may not get the results you want.

If its going to cure the patient, I think its all worthwhile to go through, Dr. Jakub Svoboda, medical oncologist at Penn Medicine, tells SurvivorNet. If, on the other hand, a stem cell transplant isnt likely to result in a cure, it may not be a good choice for you.

One clue that can help your doctor decide whether a stem cell transplant is worth the risks involved is how well you responded to chemotherapy after your cancer relapsed. People with an aggressive lymphoma that didnt respond well to chemotherapy tend not to have a good outcome from a stem cell transplant.

Having a combination imaging test called a PET/CT scan before a stem cell transplant can help pinpoint your response to chemo, and let you avoid some potentially severe side effects if this treatment isnt likely to cure you. The PET/CT technology has allowed us to select the patients who will likely benefit from autologous STEM cell transplant, Dr. Svoboda says.

The PET/CT scan combines two common cancer imaging tests. PET stands for positron emission tomography. Before the test, you get an injection of a small amount of radioactive sugar, called fluorodeoxyglucose-18 (FGD-18). Because cancer cells use a lot more energy than healthy cells, they absorb the sugar in larger amounts. As the tracer collects in the cancer, it makes those areas light up and become visible, so your doctor can see them on the scan.

CT is short for computed tomography. It takes x-rays of your body from different angles, to create a cross-sectional view of your organs and tissues. The CT scan can reveal areas of your body that are enlarged from the cancer. It alone isnt sensitive enough to pick up metabolically active areas of cancer, which is why the two tests are combined.

A computer combines the PET and CT images to give your doctor a highly detailed, three-dimensional view of your cancer. Having both of these tests together can show your doctor not only whether your cancer is shrinking, but also if its still active.

When people still have some metabolic activity within shrinking areas of cancer, they actually dont do well with the transplant, Dr. Svoboda says.

Its very helpful for doctors to have the information from a PET/CT scan, Dr. Svoboda tells SurvivorNet. You can then offer that patient a different treatment or steer them toward some of the novel therapies.

One alternative to stem cell transplant is chimeric antigen receptor (CAR) T-cell therapy. Its a promising treatment for some people with aggressive non-Hodgkin lymphoma that hasnt responded to other treatments. CAR T-cell therapy involves genetically modifying your own immune cells so that they attack your cancer. CAR T-cell therapy or other treatments actually may have a better chance at working than transplanting in this setting, Dr. Svoboda says.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Jakub Svoboda is a medical oncologist at Penn Medicine, andassociate professor of medicine at the Hospital of the University of Pennsylvania. Read More

Related: What is Autologous Stem Cell Transplant?

If its going to cure the patient, I think its all worthwhile to go through, Dr. Jakub Svoboda, medical oncologist at Penn Medicine, tells SurvivorNet. If, on the other hand, a stem cell transplant isnt likely to result in a cure, it may not be a good choice for you.

One clue that can help your doctor decide whether a stem cell transplant is worth the risks involved is how well you responded to chemotherapy after your cancer relapsed. People with an aggressive lymphoma that didnt respond well to chemotherapy tend not to have a good outcome from a stem cell transplant.

Having a combination imaging test called a PET/CT scan before a stem cell transplant can help pinpoint your response to chemo, and let you avoid some potentially severe side effects if this treatment isnt likely to cure you. The PET/CT technology has allowed us to select the patients who will likely benefit from autologous STEM cell transplant, Dr. Svoboda says.

The PET/CT scan combines two common cancer imaging tests. PET stands for positron emission tomography. Before the test, you get an injection of a small amount of radioactive sugar, called fluorodeoxyglucose-18 (FGD-18). Because cancer cells use a lot more energy than healthy cells, they absorb the sugar in larger amounts. As the tracer collects in the cancer, it makes those areas light up and become visible, so your doctor can see them on the scan.

CT is short for computed tomography. It takes x-rays of your body from different angles, to create a cross-sectional view of your organs and tissues. The CT scan can reveal areas of your body that are enlarged from the cancer. It alone isnt sensitive enough to pick up metabolically active areas of cancer, which is why the two tests are combined.

A computer combines the PET and CT images to give your doctor a highly detailed, three-dimensional view of your cancer. Having both of these tests together can show your doctor not only whether your cancer is shrinking, but also if its still active.

When people still have some metabolic activity within shrinking areas of cancer, they actually dont do well with the transplant, Dr. Svoboda says.

Its very helpful for doctors to have the information from a PET/CT scan, Dr. Svoboda tells SurvivorNet. You can then offer that patient a different treatment or steer them toward some of the novel therapies.

One alternative to stem cell transplant is chimeric antigen receptor (CAR) T-cell therapy. Its a promising treatment for some people with aggressive non-Hodgkin lymphoma that hasnt responded to other treatments. CAR T-cell therapy involves genetically modifying your own immune cells so that they attack your cancer. CAR T-cell therapy or other treatments actually may have a better chance at working than transplanting in this setting, Dr. Svoboda says.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Jakub Svoboda is a medical oncologist at Penn Medicine, andassociate professor of medicine at the Hospital of the University of Pennsylvania. Read More

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Could an Imaging Test Predict How Well Youll Respond to a Stem Cell Transplant? - SurvivorNet

AllTheResearchs published a research report on the Canine Stem Cell Therapy market, which represents a study for the period from 2020 to 2026. The research provides a near look at the market scenario and dynamics impacting its growth. This report highlights the crucial developments along with other events happening in the market which are marking on the growth and opening doors for future growth in the coming years. Additionally, the report is built based on the macro- and micro-economic factors and historical data that can influence the growth.

The global Canine Stem Cell Therapy market was valued at US$ 118.5 Mn in 2018 and is expected to reach US$ 240.7 Mn in 2026, growing at a CAGR of 9.3% during the forecast period.

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The global Canine Stem Cell Therapy market has been comprehensively analyzed and the different companies that occupy a large percentage of the market share in the regions mentioned have been listed out in the report. Industry trends that are popular and are causing a resurgence in the market growth are identified. A strategic profile of the companies is also carried out to identify the various subsidiaries that they own in the different regions and who are responsible for daily operations in these regions.

The Key Players Covered in Canine Stem Cell Therapy Market Study are:

How Report will help you to make decisions for business:

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Canine Stem Cell Therapy Market Segmentation

Canine Stem Cell Therapy market is split by Type and by Application. For the period 2015-2026, the growth among segments provide accurate calculations and forecasts for sales by Type and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.

Market Segmentation by Type:

Market Segmentation by Applications:

COVID-19 Impact on Canine Stem Cell Therapy Market:

The outbreak of COVID-19 has brought along a global recession, which has impacted several industries. Along with this impact COVID Pandemic has also generated few new business opportunities for Canine Stem Cell Therapy Market. Overall competitive landscape and market dynamics of Canine Stem Cell Therapy has been disrupted due to this pandemic. All these disruptions and impacts has been analysed quantifiably in this report, which is backed by market trends, events and revenue shift analysis. COVID impact analysis also covers strategic adjustments for Tier 1, 2 and 3 players of Canine Stem Cell Therapy Market.

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AllTheResearch was formed with the aim of making market research a significant tool for managing breakthroughs in the industry. As a leading market research provider, the firm empowers its global clients with business-critical research solutions. The outcome of our study of numerous companies that rely on market research and consulting data for their decision-making made us realise, that its not just sheer data-points, but the right analysis that creates a difference.While some clients were unhappy with the inconsistencies and inaccuracies of data, others expressed concerns over the experience in dealing with the research-firm. Also, same-data-for-all-business roles was making research redundant. We identified these gaps and built AllTheResearch to raise the standards of research support.

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Canine Stem Cell Therapy Market: Market Growth Factors, Applications, Regional Analysis, Key Players and Forecasts by 2026 - PRnews Leader

Blood cancer is a disorder that affects the production as well as the normal functioning of blood cells. The process of normal blood cell development is disturbed because of the uncontrolled growth of abnormal blood cells. These abnormal or cancerous cells disrupt the normal functions of blood components such as preventing bleeding and defending infections.

Blood Cancer (Haematopoietic malignancies) is one of the top 10 cancers in India and as per the latest Cancer Report of ICMR, it is estimated that by 2025 nearly 1.38 lakh people would be affected. Currently, around 1.25 lakh people are suffering from the disease which constitutes 9% of total cancers in the country.

While speaking about blood cancer, Dr Divya Bansal, Consultant - Clinical Hematology and Stem Cell Transplant, HCMCT Manipal Hospitals, New Delhi, said, "Blood is a liquid medium present throughout the body and not confined to a defined area, which makes blood cancers and their treatment very different from solid-organ cancers. There is a limited role of surgery and radiation therapy in the treatment of blood cancers, as they are thermosensitive."

She continued, "Chemotherapy treatment for blood cancers is much more intense in comparison to solid cancers and hence, their side effects. Also, the staging of blood cancers is very different from solid cancers and concept of metastasis is not applicable for blood cancers."

"In the case of blood cancers, prognostic risk stratification is important. Bone marrow transplant has a limited role in solid cancers but remains the curative treatment for blood cancers. This difference has actually led to the development of a completely different speciality for treatment of blood cancers i.e. Haemato-oncology, all over the world," Dr Divya Bansal added.

Meanwhile, in order for us to understand the types of blood cancers, its symptoms and treatment, Dr Divya Bansal carefully explained each one and helped us list them out.

Take a look.

Types of blood cancers

Leukaemia

This is caused by the fast production of abnormal white blood cells, and these abnormal are seen in blood and the bone marrow. A large number of abnormal WBCs are unable to defend infections.

Lymphoma

This is a type of blood cancer that involves the lymphatic system. Abnormal lymphocytes turn into lymphoma cells that multiply and get accumulated in the lymph nodes. Gradually, these cancer cells impair the immune system.

Myeloma

This affects the plasma cells, the cells that produce antibodies against disease in the body. Myeloma cells disturb the normal development of antibodies and make the body susceptible to infection.

Symptoms

- Fever- Weight loss- Loss of appetite- Bony pains- Bleeding from any sites- Generalised weakness and fatigue- Night sweats- Nodular swelling around the neck, axilla or groin- Abdominal swelling

Diagnosis

One can get the disease diagnosed with the help of a blood test, bone marrow aspiration, and biopsy. In cases of lymphoma, one must opt for a lymph node biopsy. Other options include PET-CT, specialized tests such as Flowcytometry or Immunohistochemistry, Fluorescent in situ hybridization (FISH), Karyotyping and Next-generation sequencing (NGS) which is the latest technique of diagnosing and risk stratification of blood cancers.

Treatment

Chemotherapy

An oral or injectable drug that travels in the bloodstream throughout the body and kills the cancer cells. It damages cancer cells and stops division and growth of it, leading to their death.

Immunotherapy

It refers to agents that use the bodys immune system to help fight diseases such as blood cancer. It can work directly with your bodys immune system to stop or slow the growth of cancer cells. Biologic therapies include substances made by the body or in a lab. Cytokines, Gene therapy, and Immunomodulators, and Monoclonal antibodies are the main types of immunotherapy.

Targeted therapy

Therapies that target a certain genetic mutation known to occur in a specific blood cancer is called targeted therapy. Here, we target a protein that is present in cancer cells due to mutation. As soon as a mutation is identified, we can develop a treatment to target that target. Destroying cancer cells is the main aim of this therapy.

Bone Marrow Transplantation (BMT)

It is a procedure where a damaged or non-functional bone marrow cells are replaced by healthy multipotent hematopoietic stem cells.

Overall, BMT remains the only curative treatment for most of the blood cancers. There are two types of bone marrow transplant procedure used in the treatment of blood cancers -- Autologous BMT, when patient's own stem cells are infused back after high dose chemotherapy, and, Allogenic BMT, when the source of stem cells is a healthy donor, either related or unrelated.

A few blood cancers if treated promptly and effectively can be managed well and even cured.

Examples of blood cancers which can be cured include Acute Promyelocytic leukaemia, Chronic myeloid leukaemia, Hairy cell leukaemia, and Paediatric Acute lymphoblastic leukaemia.

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Know all about types of blood cancer, its symptoms, diagnosis and treatment - DNA India

Global Canine Stem Cell TherapyMarket 2020-2026 Key Challenges. Industry Risks and Worldwide Opportunities during Covid-19.

Market Research Vision published latest Research Report on Global Canine Stem Cell TherapyMarket 2020. Research study explores economical impact of pandemic on Canine Stem Cell Therapyindustry Segment as follows:

By Important Manufacturers Aratana Therapeutics, Okyanos, Magellan Stem Cells, Stem Cell Vet, VetStem Biopharma, Medrego, Regeneus Ltd, MediVet Biologic, Cell Therapy Sciences

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The report has segmented market 20202026 into different components on the basis of products, Application, geography and end users wherever needed. With thorough analysis and detailed study of past, present and future market 20202026 conditions, the report is able to delivery factual and reliable information to the users.

By Region / Countries

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Our Research Experts have made this insightful report on Canine Stem Cell Therapymarket, which is available for user on the site of Market Research Vision. The report carries various factors and elements of the industry in picture, all around the globe, be it its potential or probable threat to its growth or simply the way and method of its functioning during covid-19.

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In-Depth Report on Canine Stem Cell Therapy Market 2020|by Top Key players Aratana Therapeutics, Okyanos, Magellan Stem Cells, Stem Cell Vet - The...

After a tendon injury occurs, horses need time off work with a period of box rest. Controlled exercise is then introduced, which is built up slowly to allow a very gradual return to work. This controlled exercise is an important element of the rehabilitation process, as evidence suggests that exposing the tendon to small amounts of strain has positive effects on the remodelling phase of tendon healing. However, depending on the severity of the initial injury, it can take up to a year before a horse can return to racing. Furthermore, when tendon injuries heal, they repair by forming scar tissue instead of regenerating the normal tendon tissue. Scar tissue does not have the same strength and elasticity as the original tendon tissue, and this makes the tendon susceptible to re-injury when the horse returns to work. The rate of re-injury depends on the extent of the initial injury and the competition level that the horse returns to, but re-injury rates of up to 67% have been reported in racing thoroughbreds. The long periods of rest and the high chance of re-injury therefore combine to make tendon injuries the most common veterinary reason for retirement in racehorses. New treatments for tendon injuries aim to reduce scar tissue formation and increase healthy tissue regeneration, thereby lowering the risk of horses having a re-injury and improving their chance of successfully returning to racing.

Over the past 15 years, the use of stem cells to improve tendon regeneration has been investigated. Stem cells are cells which have the remarkable ability to replicate themselves and turn into other cell types. Stem cells exist from the early stages of development all the way through to adulthood. In some tissues (e.g., skin), where cells are lost during regular turnover, stem cells have crucial roles in normal tissue maintenance. However, in most adult tissues, including the tendon, adult stem cells and the tendon cells themselves are not able to fully regenerate the tissue in response to an injury. In contrast, experimental studies have shown that injuries to fetal tissues including the tendon, are capable of undergoing total regeneration in the absence of any scarring. At the Animal Health Trust in Newmarket, we have an ongoing research project to identify the differences between adult and fetal tendon cells and this is beginning to shed light on why adult cells lead to tendon repair through scarring, but fetal cells can produce tendon regeneration. Understanding the processes involved in fetal tendon regeneration and adult tendon repair might enable new cell based and/or therapeutic treatments to be developed to improve tendon regeneration in adult horses.

In many tissues, including fat and bone marrow, there is a population of stem cells known as mesenchymal stem cells (MSCs). These cells can turn into cells such as bone, cartilage and tendon in the laboratory, suggesting that they might improve tendon tissue regeneration after an injury. MSC-based therapies are now widely available for the treatment of horse tendon injuries. However, research has demonstrated that after injection into the injured tendon, MSCs do not turn into tendon cells. Instead, MSCs produce factors to reduce inflammation and encourage better repair by the tissues own cells. So rather than being the builders of new tendon tissue, MSCs act as the foreman to direct tissue repair by other cell types. Although there is some positive data to support the clinical application of MSCs to treat tendon injuries in horses, placebo controlled clinical trial data is lacking. Currently, every horse is treated with its own MSCs. This involves taking a tissue biopsy (most often bone marrow or adipose tissue), growing the cells for 2-4 weeks in the laboratory and then injecting them into the site of injury. This means the horse must undergo an extra clinical procedure. There is inherent variation in the product, and the cells cannot be injected immediately after an injury when they may be the most beneficial.

To allow the prompt treatment of a tendon injury and to improve the ability to standardise the product, allogeneic cells must be used. This means isolating the cells from donor horses and using them to treat unrelated horses. Experimental and clinical studies in horses, mice and humans suggest that this is safe to do with MSCs, and recently an allogeneic MSC product was approved for use in the EU for the treatment of joint inflammation in horses. These cells are isolated from the circulating blood of disease-screened donor horses and are partially turned into cartilage cells in the laboratory. They are then available off the shelf to treat unrelated animals. Allogeneic MSC products for tendon injuries are not yet available, but this would provide a significant step forward as it would allow horses to be treated immediately following an injury. However, MSCs exhibit poor survival and retention in the injured tendon and improvements to their persistence in the injury site, and with a better understanding of how they aid tissue regeneration, they are required to enable better optimised therapies in the future.

Our research has previously derived stem cells from very early horse embryos (termed embryonic stem cells, ESCs. Figure 2). ESCs can grow in the laboratory indefinitely and turn into any cell type of the body. These properties make them exciting candidates to provide unlimited numbers of cells to treat a wide range of tissue injuries and diseases. Our experimental work in horses has shown that, in contrast to MSCs, ESCs demonstrate high survival rates in the injured tendon and successfully turn into tendon cells. This suggests that ESCs can directly contribute to tissue regeneration.

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Outlook for stem cell therapy - its role in tendon regeneration - different treatments for horse tendon injuries - Trainer Magazine