Safari Veterinary Care Centers offers a consultative service that allows our remote clients to treat their pets for IMHA or ITP with stem cell therapy through their local veterinarian or internist. Our doctors will consult with your local veterinarian or internist about your pets case so that even if you dont live close to us, you can still access this life saving treatment.

Stem cells can be overnight shipped to your veterinarian to administer intravenously to your pet for IMHA or ITP and other immune mediated diseases. Because the dose and treatment plan are tailored specifically to your pet, your case will first be evaluated by our doctors.

If your pet has been diagnosed with primary IMHA or ITP, you will need to have the pets records emailed to us so that our doctors can evaluate your case to be certain the pet is a good candidate for the cells (see FAQs below.) While your pet may be a good candidate for stem cell therapy, your pet may not, however, be a good candidate for the surgical procedure required for harvesting his own (autologous) stem cells. Your pet also may not be able to wait for the expansion of these cells to therapeutic numbers, as it takes a few weeks to grow enough cells for a therapeutic dose. Therefore, we offer allogenic stem cells from donor pets that are effective and available right now.

Once we determine that your pet is a good candidate for stem cells we will consult with you on the phone to be sure your questions are answered and see if youd like to proceed. If so, you will set up an appointment with your vet for the cells to be administered and request a ship date from Safari. We will take your payment over the phone and arrange to ship the cells to your veterinarian. We will then follow up with you and/or your vet to determine if and when your pet requires any more cells.

Please read through the list of Frequently Asked Questions below for more information.

Please provide us with the following information to get started. A Safari representative will be in touch with you as soon as possible.

The stem cells are $1000 plus $250 for overnight shipping throughout the U.S. per round of cells. Your vet will also charge a fee to catheterize your pet and administer the cells and possibly also a visit fee.

In addition to the diagnostic tests already completed to confirm your pets diagnosis, we recommend an abdominal ultrasound and/or abdominal x-rays to rule out the presence of any active tumors.

While we have experienced complete remission with only 1 round, our current recommendation is for your pet to receive at least 2 rounds of cells. Each case is evaluated individually after the first round of cells to determine this. Our doctors at Safari will consult with your vet to make this determination based on the pets blood work and how well your pet is responding. We have had cases that have required multiple rounds of cells. These cases, however, usually involve damage to the precursor cell lines in the bone marrow and present as non-regenerative. Therefore if your pet is regenerative (i.e., producing a sufficient amount of red blood cells), two to three rounds are needed on average. If your pet is non-regenerative, more rounds will likely be needed. In either case, there is no way to predict this ahead of time.

No. The sicker your pet is, the sooner he needs stem cells! Stem cells are not hard on the body like blood transfusions, and, in fact, will help your pet feel better overall. As long as your pets pcv is above 12%, the cells can be given without requiring a blood transfusion. (Your vet may feel more comfortable at a higher level.) If the pcv is lower than 12%, a blood transfusion is needed, although the pet can receive stem cells immediately afterward. We recommend getting stem cells into your pet early in their treatment so the cells can begin to reset the immune system and stop the red cell destruction as early as possible.

No, your vet does not need to take a sample of your pets fat tissue. Since most dogs with IMHA are too ill to tolerate surgery, we keep stem cells on hand, ready to ship. Safari stem cells are taken from abdominal fatty tissue of donor dogs in our hospital who come in for routine spays. They are young, healthy dogs whose stem cells are vibrant and reproduce quickly. We keep the cells alive in our lab until they are shipped and do not freeze them. These cells are universally donatable without issue and are put through viability checks and live cells counts to be sure the dose is correct for your pet.

You will request the cells directly through Safari by filling out the questionnaire here on our website. Have your pets records available or be ready to have your vet send them to us. You may also call us at 281-332-5612 with further questions if youd like.

We ask that you give us at least a 24 hr notice ahead of your requested delivery date. Because we use overnight shipping through UPS and FedEx, we are only able to ship Mondays through Fridays for delivery Tuesdays through Saturdays. Shipments usually arrive between 10:00 and 10:30 am. The cells must be administered the day they arrive and cannot be stored for later use.

Your vets involvement is to manage your pets case and administer the stem cells intravenously. We ask that you make all the purchasing and shipping arrangements with us. The cells will be shipped to your vet. You will need to have an appointment set up with your vet after 10:00 am the day the cells are scheduled to arrive.

You will pay Safari directly for the stem cells. Your vet will also charge you to administer the cells. When we are ready to take payment, we will contact you and take your payment information over the phone. We accept major credit cards, Care Credit, and ScratchPay.

Since the cells will only live for about 72 hours after leaving our lab, they need to be administered to the pet the day they arrive. Therefore, only one round can be shipped at a time.

Stem cell therapy is not yet taught in vet school and most vets who now use stem cells usually only treat arthritis and sports injuries. This means yourvet will most likely not be aware that a supply of stem cells is available to them or even what these cells can do for the immune system. Because of this, you will need to ask your local vet or internist if they will give the cells to your pet intravenously. We will help by providing information for you to pass along to your vet that details how stem cells work with the immune system as well as our administration protocols. We will work with your vet to answer any of their questions.

We do not have a list of vets that we work with. Instead, we depend on our clients to speak with their local vet or internist about giving the cells. We are happy to let you know if weve previously worked with a vet in your area that you may then contact.

We are happy to give you our administration protocols to share with your vet. It simply involves placing an I.V. catheter and extender tube if needed the day the cells are to be administered.

No. All that is needed is to have an I.V. catheter placed and the cells can be given by a vet or vet tech. No other equipment is needed.

Yes pets need the immunosuppressants to help stop the cell destruction as soon as possible. Therefore, we recommend that your pet continue with his current medications while receiving the stem cells. Stem cells and medications are not mutually exclusive and can be given at the same time. Your vet will continue to monitor your pets case and wean them off their meds as their pcv and other elements of their blood work return to normal. We will consult with your vet as needed.

While we have seen some of our stem cell patients able to wean off their medications more quickly than non-stem cell patients, most pet parents are not in a rush to do so. Since our remote patients care is managed by their local vets, we do not set their weaning schedules. Because of this, we simply do not have the data. Your vet will provide a plan to get your pet off the drugs which usually cuts the medications back by 25% every month following stable blood work within the normal ranges.

Stem cells are naturally present in the body; we simply send in reserves. Therefore, they are all natural and are not harmful like drugs can be. There is a slight chance of allergic reaction, although this is very rare. This reaction is not to the stem cells themselves, but to the bovine serum the cells are fed to keep them alive in our lab. The stem cell infusion can be stopped if any reaction is seen and the pet can be given a Benadryl injection. The pet can also be pre-treated with Benadryl if you or your vet prefers.

Unlike blood transfusions or organ donation which must be matched, stem cells are universally donatable. These donor cells do not remember where they came from and only await instructions from their new environment to start working. Therefore, your pet will not reject the cells.

Before shipping the cells, our doctors will review and evaluate your pets records. We will be looking to see that the pet has been diagnosed with primary IMHA and that there are no complicating factors. We recommend the pet be screened for active tumors through abdominal radiographs or ultrasound. A bone marrow aspirate is not required. It does not matter if your pet is critically ill or stable; the cells can still be administered.

With over 50 IMHA patients treated with stem cell therapy, we experience at least a 75% rate of remission. A much higher percentage of our regenerative patients go into remission. Theoretically, pets should not relapse after their stem cell treatment is completed, although studies are needed to prove this assumption. We have not experienced relapse in any of our regenerative patients who finished their treatment with us in almost 3 years.

The cells are administered through an I.V. catheter by your vet or vet tech.

The cells are given at the rate of 1ml per minute, so it depends on the size of the dog. On average, this takes about 30 minutes for a small dog and an hour for larger dogs.

Not unless the pet is already hospitalized or if a blood transfusion has been given recently and the pet needs to be watched. Your vet will make this determination, but generally pets do not need to be watched or kept overnight following stem cell therapy.

No, your pet will not need to be sedated to get the cells.

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How Can I Get Stem Cells for my Pet as Soon as Possible ...

Canine stem cell therapy is a disease-modifying therapy used for the treatment of degenerative disorders such as arthritis of hips, elbows, shoulders, etc.

Factors like rising prevalence of canine arthritis and increasing investment in research and development are expected to accentuate the growth of the canine stem cell therapy market. However, stem cell therapy is an expensive procedure as compared to other treatment options and this is impeding the growth of the market. Moreover, the lack of pet insurance will further restrain the growth of the market.

Based on type, the global canine stem cell therapy market has been segmented into autologous stem cells and allogeneic stem cells. The autologous stem cells segment accounts for more than 80% of the global canine stem cell therapy market. This segment is expected to reach $xx million by 2026 from $xx in 2019, growing at a significant rate

Based on applications, the market has been segmented into treatment and research. The treatment segment accounts for the largest share in the global canine stem cell therapy market by application.

Based on the end-user, the market has been segmented into veterinary hospitals, veterinary clinics, and veterinary research institutes. The veterinary clinics segment accounts for the largest share in the market and held more than 60% of the total market in 2018.

North America accounted for the highest share in 2018 and is expected to continue its dominance in the market throughout the forecast period. North America has the highest population of pet dogs, with around 73 million dogs in the US and over 6 million in Canada. The rising pet ownership in this region is one of the most important factors driving the growth of this market. The US accounted for around 90% of the market in 2018. The rising research and development activity in this region will also augment the growth of the canine stem cell therapy market.

Company Profiles and Competitive Intelligence:

The major players operating in this market are VetStem Biopharma, Medrego, and Magellan Stem Cells, amongst others. Most of the companies are conducting clinical trials to study the safety and efficacy of stem cells for various indication such as spinal disorders, renal disorders, etc.

Source @ https://inforgrowth.com/report/6322118/canine-stem-cell-therapy-market

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For all your Research needs, reach out to us at:Address: 6400 Village Pkwy suite # 104, Dublin, CA 94568, USAContact Person: RohanEmail: sales@inforgrowth.comUS: +1-909-329-2808UK: +44 (203) 743 1890

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Canine Stem Cell Therapy Industry Revenue Analysis with Impact of COVID19 - PharmiWeb.com

SAN DIEGO, Sept. 16, 2020 /PRNewswire/ --Poseida Therapeutics, Inc., (Nasdaq: PSTX),a clinical-stage biopharmaceutical company dedicated to utilizing proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure, today will present data related to its proprietary manufacturing process designed to optimize its CAR-T product candidates. The Company will also illustrate the impact of these optimizations with preclinical data and preliminary clinical analysis with a focus on P-BCMA-101, its autologous CAR-T product candidate for multiple myeloma. The findings will be presented today at CAR-TCR Digital Week 2020 being held September 14-17, 2020.

Utilizing its proprietary piggyBac DNA Modification System, Poseida's non-viral manufacturing process can produce highly purified CAR-T treatment candidates comprised of a high percentage of stem cell memory T, or TSCM, cells. These high-TSCM product candidates may improve therapeutic response and tolerability profile as compared to existing CAR-T therapies using viral-based manufacturing methods.

In ongoing efforts to optimize manufacturing, the Company was able to demonstrate increased transposition frequency by using Nanoplasmid technology licensed from Nature Technology Corporation, which, when compared to a standard plasmid, yields more CAR-positive cells at the start of the process. In turn, this reduces manufacturing timelines, has resulted in a higher proliferative capacity in patients, and has the potential to create more efficacious CAR-T products with less toxicity.

Poseida also conducted a preliminary clinical analysis of P-BCMA-101 to test the impact of using a Nanoplasmid in its manufacturing process compared to a standard plasmid. The analysis conducted at a .75 X 10E6 per kg dose found that all patients (n=3) responded to treatment with Nanoplasmid-manufactured P-BCMA-101 and that responses were deep, showing a 100 percent overall response rate (ORR) as compared to an ORR of 50-67% in patients that received P-BCMA-101 manufactured using a standard plasmid at that same dose (n=3, 2 evaluable by IMWG criteria; third patient with plasmacytomas and significant response by PET scan). The three patients given Nanoplasmid-produced P-BCMA-101 at this dose reached a very good partial response (VGPR) or stringent complete response (sCR) compared to a partial response (PR) achieved with the standard plasmid. Notably, using a Nanoplasmid in the manufacturing process did not impact the safety profile of P-BCMA-101 and no incidence of cytokine release syndrome of any grade was observed in patients.

"At Poseida, we are always looking at innovative ways to further improve the performance of our CAR-T product candidates while maintaining an exceptionally low rate of cytokine release syndrome and other potential toxicities," said Eric Ostertag, M.D., Ph.D., Chief Executive Officer of Poseida. "As our most advanced product candidate, we look forward to providing further updates to our clinical program for P-BCMA-101 later in the year."

P-BCMA-101 has received regenerative medicine advanced therapy (RMAT) status and orphan drug designation from the FDA and is currently being tested in an expanded Phase 1 clinical trial for the treatment of patients with relapsed/refractory multiple myeloma to inform the potentially registrational Phase 2 clinical trial. Poseida's portfolio includes allogeneic and autologous CAR-T product candidates in both hematological and solid tumor oncology indications, as well as liver-directed gene therapy programs in orphan genetic diseases.

Nanoplasmid-produced product candidates P-BCMA-101 for multiple myeloma and P-PSMA-101 for castrate resistant prostate cancer have both demonstrated robust expansion in patients to date. The Company is now utilizing Nanoplasmid technology to manufacture all autologous and allogeneic product candidates across its portfolio and continues to evaluate additional manufacturing optimizations that may further improve the performance of its product candidates.

The full presentation at CAR-TCR Digital Week will be available on Poseida's website at the end of the meeting on Thursday, September 17.

About Poseida Therapeutics, Inc.Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBacDNA Modification System, Cas-CLOVER site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics.

About Nature Technology CorporationNature Technology Corporation is a developer of safe and effective nucleic acid-based gene therapeutics, DNA vaccines, and associated technologies, including antibiotic-free selection (RNA-OUT), regulatory compliance, viral vector retrofitting, and best in class NanoplasmidsTM. NTC proprietary vector and manufacturing platforms offer wide applications to improve the safety and performance of plasmids and biologics.

Forward-Looking StatementsStatements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding the preclinical and clinical data presented, the potential benefits ofPoseida'stechnology platforms and product candidates andPoseida'splans and strategy with respect to developing its technologies and product candidates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based uponPoseida'scurrent expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry and the other risks described inPoseida'sfilings with theSecurities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made.Poseidaundertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.

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Poseida Therapeutics to Present CAR-T Manufacturing Process Optimization Data at CAR-TCR Digital Week 2020 - thepress.net

Laser pointers used to exercise pets may seem like safe and simple low-powered devices, but an Ohio teen learned the hard way that staring at the narrow beam can cause permanent eye damage.

His minimal vision loss tells some of the story, but a high-resolution optical imaging device developed by Ohio State University researchers showed in stark detail that cells in the boys retinas are missing blasted away by the laser, his ophthalmologist explained.

This area of the eye is home to photoreceptors, light-sensitive cells (often referred to as rods and cones) that allow us to see. These cells are most dense in the center of the retina and give us the perception of vision and color.

Theres just nothing left there, said Frederick Davidorf, professor of ophthalmology and visual science at Ohio State and co-author of a paper describing the case. The affected areas are devoid of cones.

Only with the optical scanning system, engineered by Nathan Doble, associate professor of optometry at Ohio State, could scientists count individual cells to see precisely what had happened to the teens eyes. Both eyes were damaged, the right more extensively.

The case study is published online in the journal Retinal Cases & Brief Reports and will appear in a future print issue.

The case serves as a cautionary tale about the risk of staring at laser pointers, which both Doble and Davidorf noted often pack much more power than advertised.

It is also the first published report of laser eye damage captured by this specific imaging system, showing how valuable this research equipment can be in understanding the exact extent of damage caused by the laser.

The imaging system can be thought as a powerful microscope that can magnify the view of retinal cells that are equal in size to about 1/20th the width of a human hair. One of the main research goals in Dobles lab is to utilize such high-resolution imaging systems to detect and monitor various eye diseases such as age-related macular degeneration, diabetic retinopathy and glaucoma.

It has been described as looking at the retina through a straw, said Doble, a lead author of the paper. We can see much more detail than you would see with standard clinical imaging. We do not image large areas of the retina, but the areas we do image are at a much higher level of resolution.

The 14-year-old boy, not identified in the article, and a friend were playing with pet laser pointers when he stared directly at the laser for several seconds. He described the initial effect as a bright light that limited his vision for several minutes.

By the time he saw Davidorf five months later, the patient said that if he were looking at text with only his right eye, a single letter would be missing, but with both eyes he could not detect any problems. Though he otherwise had 20/25 and 20/20 vision, a standard clinical exam showed lesions in both eyes that were diagnosed as macular laser burns.

The damage came into clearer view when Doble imaged the retinas with his device, called an adaptive optics-optical coherence tomography-scanning laser ophthalmoscope: The two lesions in the right eye and one in the left eye appear as black gaps in a sea of individual cells.

The scope is equipped with a specialized mirror that has been deformed almost like a funhouse mirror, Doble said, correcting for the slightest motions even motion related to the patients heartbeat as the researchers shine light into the eye.

The mirror allows us to bypass the optics of the aberrations or distortions in your eye and gives us the really sharp image of the back of the eye, Doble said. Each individual image covers only a small field of view, so the researchers stitch images together to see the entire target area of concern.

The high-resolution images are similar to what scientists can see when they view a slice of tissue under a microscope only in this case, the tissue doesnt have to be biopsied to be seen up close.

Doble, also an associate professor of ophthalmology and visual science, doesnt intend to market the scope or make it widely available it is one of only five known custom-built devices of its kind in the United States. As an optical engineer, his emphasis is producing images that can help increase understanding of eye diseases as they progress.

Most recently, his lab published images of retinal cells called ganglion cells from patients with glaucoma, a disease that damages the optic nerve.

The ganglion cells are some of the first cells affected by glaucoma, so potentially counting these cells might be a very sensitive measure for this condition, Doble said. We can also follow the same patient over time so the potential of new stem-cell or genetic therapies can be evaluated objectively by counting the number of individual cells as the disease progresses.

In this case study, the researchers scanned the teens eyes twice, 11 and 20 months after the injury, and found slight decreases in the size of the lesions over that time period.

But its never going to fully heal, Davidorf said. There will always be scarring there.

Other Ohio State co-authors of the study include Carol Vitellas, Elaine Wells-Gray, Nayanika Challa and Stacey S. Choi.

Read more:
Pet laser pointers have enough power to blast away cells in the back of the eye - The Ohio State University News

08/07/2020 First males that can reproduce with sperm from donor animals.

Scientists have genetically edited the first animals capable of being viable surrogate males: they produce sperm that carry only the genetic traits of donor animals.

RESEARCH AND TECHNOLOGY POLICYWASHINGTON STATE UNIVERSITY / ROBERT HUBNER

MADRID, 15 (EUROPA PRESS)

Scientists have genetically edited the first animals capable of being viable surrogate males: they produce sperm that carry only the genetic traits of donor animals.

This groundbreaking research, published in the Proceedings of the National Academy of Sciences on September 14, could accelerate the spread of desirable traits in livestock and improve food production for a growing world population.

It would also allow breeders in remote regions better access to genetic material from elite animals from other parts of the world and allow for more accurate reproduction in animals such as goats, where artificial insemination is difficult to use.

With this technology, we can achieve better dissemination of desirable traits and improve the efficiency of food production. This can have a major impact in addressing food insecurity worldwide, Jon Oatley, a reproductive biologist, said in a statement. from the College of Veterinary Medicine at Washington State University. If we can address this genetically, then that means less water, less food, and fewer antibiotics that we have to put into the animals.

A research team led by Oatley used the gene-editing tool, CRISPR-Cas9, to remove a specific male fertility gene in animal embryos that would be bred to become surrogate bulls. The males were born sterile, but began producing sperm after researchers transplanted stem cells from donor animals into their testes.

The sperm produced by the surrogate males contained only the genetic material of the selected donor animals. The gene-editing process used in this study seeks to provoke changes within an animal species that could occur naturally, such as infertility.

SIX YEARS OF WORK RESULT IN SUCCESS WITH MICE

The study is the result of six years of collaborative work between researchers from WSU, Utah State University, the University of Maryland and the Roslin Institute at the University of Edinburgh in the United Kingdom.

The researchers used CRISPR-Cas9 genetic scissors to produce mice, pigs, goats and cattle that lacked a gene called NANOS2 that is specific for male fertility. The males grew sterile but otherwise healthy, so when they received transplants of sperm-producing stem cells from other animals, they began to produce sperm derived from donor cells.

The surrogate males were confirmed to have active donor sperm. The mice sired healthy offspring that carried the genes of the donor mice. The largest animals have not yet been bred. Oatleys lab is perfecting the stem cell transplant process before taking the next step.

This study provides a powerful proof of concept, said Professor Bruce Whitelaw of the Roslin Institute. This shows the world that this technology is real. It can be used, Whitelaw said. Now we have to go and find out what is the best way to use it productively to help feed our growing population.

Scientists have been searching for a way to create surrogate males for decades to overcome the limitations of selective breeding and artificial insemination, tools that require close proximity of animals or tight control of their movement, and in many cases, both.

Artificial insemination is common in dairy cattle that are often confined, so their reproductive behavior is relatively easy to control, but the procedure is rarely used with beef cattle that need to roam freely to feed. For pigs, the procedure still requires animals to be close by as pig sperm does not survive freezing well. In goats, artificial insemination is quite challenging and may require a surgical procedure.

Surrogate parent technology could solve those problems, as surrogates deliver donor genetic material naturally, through normal reproduction. This allows ranchers and herders to allow their animals to interact normally in the field.

Donors and surrogates do not need to be close to each other, as the donors frozen sperm or the surrogate animal itself can be shipped to different locations. Furthermore, females knocked out by NANOS2 remain fertile, as the gene only affects male fertility, and could be bred to efficiently generate sterile males for use as surrogate males.

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Science.-First males that can reproduce with sperm from donor animals - Explica

Market Size US$ 218.2 Mn in 2026, Market Growth CAGR of 4.2%, Market Trends Growing Prevalence of Healthcare Industry

Persistence Market Research (PMR) has published a new research report on canine stem cell therapy. The report has been titled, Canine Stem Cell Therapy Market: Global Industry Analysis 2016 and Forecast 20172026.Veterinary research has been used in regenerative and adult stem cell therapy andhas gained significant traction over the last decade.

Canine stem cell therapy products are identified to have gained prominence over the past five years, and according to the aforementioned research report, the market for canine stem cell therapy will expand at a moderate pace over the next few years.

Get Sample Copy of Report @ https://www.persistencemarketresearch.com/samples/15550

Company Profiles

Get To Know Methodology of Report @ https://www.persistencemarketresearch.com/methodology/15550

Though all animal stem cells are not approved by FDA, veterinary stem-cell manufacturers and university researchers have been adopting various strategies in order to meet regulatory approvals, and streamline and expedite the review-and-approval process. The vendors in the market are incessantly concentrating on research and development to come up with advanced therapy, in addition to acquiring patents.

In September 2017, VetStem Biopharma, Inc. received European patent granted to the University of Pittsburgh and VetStem received full license of the patent then. This patent will eventually provide the coverage for the ongoing commercial and product development programs of VetStem and might be also available for licensing to other companies who are rather interested in this field.

The other companies operating in the global market for canine stem cell therapy are VETherapy Corporation, Aratana Therapeutics, Inc., Regeneus Ltd, Magellan Stem Cells, Animal Cell Therapies, Inc., and Medrego, among others.

According to the Persistence Market Research report, the globalcanine stem cell therapy marketis expected to witness a CAGR of 4.2% during the forecast period 2017-2026. In 2017, the market was valued at US$ 151.4 Mn and is expected to rise to a valuation of US$ 218.2 Mn by the end of 2026.

Burgeoning Prevalence of Chronic Diseases in Dogs to Benefit Market

Adipose Stem Cells (ASCs) are the most prevalent and in-demand adult stem cells owing to their safety profile, ease of harvest, and use and the ability to distinguish into multiple cell lineages. Most early clinical research is focused on adipose stem cells to treat various chronic diseases such as arthritis, tendonitis, lameness, and atopic dermatitis in dogs.

A large area of focus in veterinary medicine is treatment of osteoarthritis in dogs, which becomes more prevalent with age. Globally, more than 20% dogs are suffering from arthritis, which is a common form of canine joint and musculoskeletal disease. Out of those 20%, merely 5% seem to receive the treatment.

However, elbow dysplasia in canine registered a prevalence rate of 64%, converting it into an alarming disease condition to be treated on priority. Thereby, with the growing chronic disorders in canine, the demand for stem cell therapy is increasing at a significant pace.

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Expensive Nature of Therapy to Obstruct Growth Trajectory

Expensive nature and limited access to canine stem cell therapy has demonstrated to be a chief hindrance forestalling its widespread adoption. The average tier II and tier III veterinary hospitals lack the facilities and expertise to perform stem cell procedures, which necessitates the referral to a specialty vet hospital with expertise veterinarians.

A trained veterinary physician charges high treatment cost associated with stem cell therapy for dogs. Generally, dog owners have pet insurance that typically covers maximum cost associated with steam cell therapy to treat the initial injury but for the succeeding measures in case of retreatment, the costs are not covered under the pet insurance. The stem cell therapy is thus cost-prohibitive for a large number of pet owners, which highlights a major restraint to the market growth. Stem cell therapy is still in its developmental stage and a positive growth outcome for the market cannot be confirmed yet.

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Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

Our client success stories feature a range of clients from Fortune 500 companies to fast-growing startups. PMRs collaborative environment is committed to building industry-specific solutions by transforming data from multiple streams into a strategic asset.

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Canine Stem Cell Therapy Market To Witness A CAGR Of 4.2% Between 2026 - The Daily Chronicle

2020 has truly been tough on everyone in one way or another. Many people are finding reprieve in their pets. In honor of National Dog Day, Gallant conducted a survey of 1,000 Americans to learn more about how pets and pet parents have been functioning during the health crisis.

The findings truly show how wonderful pets have been as companions during this difficult time. More than 68% of pet parents surveyed have spent more time with their pets than with people during the health crisis. It makes sense, considering not every pet parent stuck at home shares their furry friend with another person.

Adoptions and fostering have both been on the rise during the health crisis. For many, the decision to become a pet parent or add to their existing brood wasnt planned. More than 79% of those surveyed didnt have plans to adopt when staying at home began.

Pets have also helped make the work-from-home grind easier for their humans. When it comes to pets making surprise cameos during a video chat, 28.5% fessed up to bringing their four-legged friends in to shake things up. Were sure 100% of coworkers have loved them for it.

That said, working from home really hasnt been the worst of it. In fact, most of the pet parents would be happy to continue working from home. Of those surveyed, 83% said they wouldnt mind continuing to work from home when all is said and done since it means more time with their fur babies.

Dog owners in particular are loving how pets are keeping them active during this time. Nearly 40% of dog owners are getting more than 5,000 steps a day compared to 21% of non-dog owners. Dog owners are getting more exercise, with 24% exercising more than they did before compared to 18.5% of non-dog owners.

There has also been another really important side effect of all that time at home. Pet parents have been more in tune with their pets health. Of those surveyed, 11% realized their pets have health issues that they werent aware of before the health crisis began.

As people start to think more about their own health, it is extending to those around them. Nearly half of the pet parents surveyed (42%) are thinking more about their pets health when making choices. That will surely lead to some well-taken-care-of pets in the years to come.

Veterinarian Shelly Zacharias, vice president of medical affairs atGallant, shared her insights into the studys findings:

If there is a silver lining to the [health crisis], it would have to be the decreased number of homeless pets and the increase in veterinary care for our furry family members. While considering our interesting survey results, I thought that adopting or fostering during such a stressful, challenging time had to be one of the most unselfish acts of humankind. But then I realized, what better way to form your own emotional support system, make the best out of a bad situation and put a smile on your face at least once a day, than adding a pet to your life?

The benefits of adopting or fostering a pet are always abundant, such as increasing lifespan, decreasing blood pressure, and helping with depression. Adding an unconditional best friend to your life during this time of turmoil has the potential to give unmeasurable physical and emotional benefits to both you and the pet. As a veterinarian, the increased number of cases coming into the veterinary hospital during the [health crisis] initially confused me, but then I experienced a feeling of optimism with the realization that people were understanding their pets health and acting on the importance of having their pets in their lives, she continued.

Pets help us through so many challenges in life by just being a constant, positive source of companionship they make us have to get up, feed them, take care of them, go outside with them to get fresh air, and walk them so they dont tear up the couch. Pets give us a feeling of being needed, of being loved, and of not feeling quite so lonely they help us get through one day at a time by always being there and needing us.

My dog knows my mood before I do, she knows she is my best friend and I am hers. I cant think of a more comforting feeling than seeing my dog, right beside me, every time I look down. And I know she finds comfort in her constants in life, she trusts me to take care of her and keep our daily routine intact regardless of the chaos surrounding me and I dont plan to let her down.

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Pet Parents Say Furry Friends Are Making The Health Crisis More Bearable, Recent Survey Shows - News Lagoon

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Prom season is kicking off a few months early.

Ryan Murphy took to social media Sunday to announce the official release date for his upcoming film adaptation of the hit Broadway musical, The Prom. The movie, which stars Meryl Streep and Nicole Kidman, will hit the streamer on Friday, Dec. 11.

The executive producer and director wrote on Twitter, Let Netflix take you to The Prom you didnt get this year, in a nod to the heaps of events cancelled by the COVID-19 pandemic.

The Prom, which opened on Broadway in November of last year, centers on four down-and-out theater actors played by Streep, Kidman, Andrew Rannells and James Corden who head to Indiana, where they help a teen (Jo Ellen Pellman) whose prom was cancelled when she tried to bring her girlfriend as her date. The cast also includes Kerry Washington, Keegan-Michael Key and Ariana Debose.

In announcing the project, Murphy said, The Prom is one of the most uplifting, heartfelt and special musicals I have ever seen on Broadway. Its truly an original that celebrates the underdog and says in a loving spectacular way that LGBTQ rights are human rights. I feel a special connection to it because its set in Indiana, and thats where I grew up, too.

Producers Bill Damaschke, Dori Bernstein and Casey Nicholaw, songwriter Matthew Sklar and book writers Bob Martin and Chad Beguelin are also on board.

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Doja Cat's Third Album Is Complete But There's A Catch - News Lagoon

Airbnb takes a singular strategy towards lodging. A part of the sharing economic system, Airbnb affords you somebodys residence as a spot to remain as an alternative of a resort. On Airbnb, yow will discover locations to crash in your backpacking journey by way of Europe, or yow will discover a spot to remain for a month throughout your internship in Los Angeles. Its additionally an effective way to discover a city youre eager about transferring to, or discovering a substitute for conventional resort choices in 2020 should youre simply round for a weekend. If you wish to lease out additional area in your individual residence, you possibly can host by way of Airbnb and make cash for permitting a visitor to remain the night time.

This all sounds fairly easy, however theres far more to Airbnb than you may think. Whats Airbnb precisely? Right heres what that you must know concerning the in style home-sharing web site earlier than you e book a keep or develop into a number.

Airbnb founders Joe Gebbia, Brian Chesky, and Nathan Blecharczyk developed the enterprise in 2008. Initially, Gebbia and Chesky began off utilizing their very own place as a bed-and-breakfast to make a number of additional bucks to pay lease. With a giant design convention coming to the San Francisco space and a metropolis stuffed with sold-out motels on the time, they noticed a possible marketplace for the concept and developed an internet site known as airbedandbreakfast.com. To fund their operation, the fellows offered breakfast cereals throughout the 2008 presidential race Obama Os and Capn McCains and the cereals earned them round $30,000.

Airbnb was not a right away success, although. The startup skilled a number of ups and downs, and it went by way of no less than three separate launches. A lot of traders didnt take the concept severely. Nevertheless, one enterprise capitalist, Paul Graham, did see a possible lottery ticket in Air Mattress & Breakfast. Graham invited the founders to affix a program known as Y Combinator, which offers a startup with money and coaching in alternate for a share of their firm. In 2009, Air Mattress & Breakfast turned Airbnb, and that was the corporates turning level.

Whereas Airbnb has misplaced some worth in 2020 (together with different hospitality ventures), the corporate has filed an IPO to go public after delaying the choice as soon as in 2019.

Airbnb doesnt personal properties. It acts as an middleman between those that need to lease out area and people who are in search of area to lease. Creating an account on Airbnb is free, and its comparatively easy. To take action, you enter your identify, e-mail tackle, birthday, and a password. Airbnb additionally asks that you simply conform to deal with everybody equally, no matter race, faith, intercourse, or different components. When you agree, your account is lively. You even have the choice to enroll by way of Fb or Google.

Airbnb has listings all around the map, from Savannah, Georgia, to Honolulu, Hawaii, to worldwide listings. Airbnb presently has greater than 6 million listings in roughly 190 international locations all over the world. When you click on on an inventory, you possibly can see a variety of details about that itemizing, together with the scale of the area and its facilities, check-in and pricing data, an in depth description of the area, home guidelines, security options, and availability. Additionally, you will see critiques from different friends and details about the hosts. For example, the hosts of an inventory in Honolulu say they love browsing, scuba diving, kite browsing, working, and mountaineering the gorgeous nature trails on Oahu.

Should you just like the itemizing, you possibly can request to e book it. The location prompts you to undergo a number of extra steps, like coming into in additional of your data. When you full these steps, you possibly can full your request and pay to your room. After your first reserving, the method is way faster and simpler.

Earlier than your reservation is closing, nonetheless, you have to watch for approval from the host, except your itemizing is an instantaneous e book itemizing, as these listings dont require host approval.

For non-instant e book listings, Airbnb additionally recommends that friends message hosts earlier than reserving to double-check availability. Should you dont hear again from the host in a well timed method, you possibly can proceed to message different hosts within the space till you discover one you want. Below the host data part of every itemizing, you possibly can see the hosts response charge and response time to get an concept of how shortly a number will reply to your message.

Airbnb is providing a brand new tier of properties known as Airbnb Plus, an elite choice of properties that stand out for his or her glorious rankings. The typical worth for these is usually increased.

Airbnb hosts and friendsdontalternate cash in particular person. Visitors pay for every thing on the Airbnb web site after they make their reservation, even having the choice to separate prices between pals, and hosts obtain pay from Airbnb. Airbnb makes use of PayPal, direct deposit, and different cost strategies.

Airbnb has totally different internet hosting choices you possibly canlease out theadditional area in your house, you possibly can lease out your whole residence, or you possibly can host experiences in your space.

Tolease outadditional area in your house, you have to first create a freeAirbnb account. Then, you click on on develop into a number within the higher right-hand nook of the web page. After that, youll have to create an inventory to your area. A list is lots like a profile web page for the area you need to host; identical to a social media profile, the nicer your web page appears to be like, the extra consideration it is going to draw. Its a good suggestion to make your area look as good as doable and take flattering photos of the area. How a lot must you cost? Airbnb helps you set the pricing by indicating the averages to your space.

You too can make cash on Airbnb by internet hosting an expertise. Airbnb experiences are actions designed and led by inspiring locals. They transcend typical excursions or lessons by immersing friends in a numbers distinctive world, says the Airbnb web site. If you wish to host an expertise, overview Airbnbs quality standards, which point out necessities for experiences. Principally, the visitor should be getting access to one thing, taking part inone thing, and supplied an uniqueperspective. After reviewing the standard requirements, design your expertise and submit it to Airbnb for approval. As soon as authorised, youare able topublish and host your expertise.

Along with the price of the room, Airbnb prices a visitor service payment that sometimes maxes out at 14.2%. Hosts additionally pay a service payment of round three%, which Airbnb provides to every transaction. Hosts who supply experiences are topic to a 20% service payment.

The worth of a room on Airbnb is dependent upon quite a lot of components, together with location, the standard of the itemizing, and the facilities. You will discover very cheap rooms on Airbnb, simply as yow will discover very cheap motels. In cities on the outskirts of main metropolitan areas, you possibly can usually discover the perfect offers. We discovered a room for $31 in Marietta, which is a metropolis close to Atlanta, Georgia.

Common each day charges on Airbnb in 2020 diverse between $205 in locations like Madison, Wisconsin, to $665 in Key West, Florida, according to the latest Mashvisor data. Due to the good selection in dimension and forms of properties on Airbnb, even a single space can see very low and really excessive costs for every kind of budgets.

You might haveheard experiences of avisitor destroying a numbers residence, a number endangering a visitors security, or an Airbnb host watching a visitor by way of a hidden digicam. Airbnb has taken some actions to assist promote security and safety for hosts and friends, comparable to having customers present identification, enhancing profile and overview methods, and implementing a number assure that reimburses eligible hosts for damages as much as $1 million. Airbnb could additionally conduct public data checks, comparable to of intercourse offender registries, to see if a consumer has a previous file.

Airbnb has additionally simply partnered with August sensible lock. Now, anytime a vacationer makes a reservation in an August Good Lock- and August Good Keypad-equipped residence, August will auto-generate a personalized entry code for the reserving time and date. No extra want to attend round for friends to reach, and with a brand new code populated each time, hosts ought to really feel a way of safety.

Airbnb legal guidelines can differ by location, and cities could have their very own particular Airbnb guidelines. Nevertheless, in 2020, Airbnb made two widespread adjustments that affected all customers and represented important adjustments for the platform.

Folks beneath 25 could also be banned from renting homes of their particular space: If somebody is beneath 25 and has fewer than three optimistic critiques from previous renting, they receivedt be capable to lease entire homes, interval. Airbnb made this transformation to crack down on a development of youthful folks renting Airbnbs for home events. This was inflicting quite a lot of harm and, in some unlucky incidents, even deaths, so Airbnb adjustments its insurance policies. The corporate has additionally issued a broad ban on any events at any location.

Cleansing necessities and certification: In response to 2020 and COVID-19, Airbnb has instituted a brand new cleansing protocol that hosts can join and earn certification in, to each keep secure and assist assure a safer expertise for friends. This consists of ready 24 hours to enter a room after a visitor has checked out and cleansing all surfaces with authorised disinfectants. Those that cant comply with these guidelines can use a 72-hour blackout interval between friends to assist guarantee security.

Airbnb isnt all underwater aquarium rooms. It has invited its share of controversy. Cities from San Francisco toNew York to Barcelona to Chicago to Berlinhave clashed with the corporate, and Airbnb has been searching for methods to compromise with locations that need to see extra regulation. Critics have accused Airbnb of exacerbating the housing disaster in San Francisco,and a decide dismissed the corporates lawsuit in opposition to town.

People have additionally complained concerning the service, with some folks saying theyve had hosts discriminate in opposition to them whereas looking for a rental. In response to a overview, Airbnb modified a few of its insurance policies, comparable to blocking hosts from accepting friends for a sure date in the event that theyve already rejected another person first. Airbnb has additionally being accused of deleting adverse critiques after a visitor claimed that the house she arrived in seemed utterly inferior to the pictures of the five-star property she booked.

Notice that if youre a number, Airbnb will ship you notifications if it has up to date its phrases of service agreements.

One advantage of utilizing Airbnb is the price, as you possibly can legitimately discover a low-cost place to remain on the positioning. Additionally, you discover out a substantial amount of detailed details about the place youll be staying beforehand, and youll speak to your host earlier than your keep. In case you are evaluating Airbnb vs. a standard resort, a number of issues to consider are:

For hosts, renting a room in your house and not using a allow is a authorized gray space. In some localities, its unlawful.Along with the authorized implications, and the plain security considerations, its a good suggestion to ensure you know what youre getting your self into. This implies studying the phrases, situations, effective print, and critiques from different customers.Its sensible for hosts to overview native legal guidelines andkeep the required insurance coverage protection earlier than renting out area of their properties. Should you resolve to e book a keepwith Airbnb, its sensible to let an in depth buddy or relative know precisely the place youll be staying, and comply with the entire security recommendation and directions on the Airbnb web site.

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Coronavirus Disease (COVID-19) Impact Global Canine Stem Cell Therapy Market Report Top Companies like VETSTEM BIOPHARMA, Cell Therapy Sciences,...