Pet Stem Cell Therapy

Global Canine Stem Cell Therapy Market 2027 Register a Xx% CAGR In Terms Of Revenue: VETSTEM BIOPHARMA, Cell Therapy Sciences, Regeneus, Aratana…

Canine Stem Cell Therapy Market

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The Major Manufacturers Covered in this Report:VETSTEM BIOPHARMACell Therapy SciencesRegeneusAratana TherapeuticsMedivet BiologicsOkyanosVetbiologicsVetMatrixMagellan Stem CellsANIMAL CELL THERAPIESStemcellvet

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By Types:Allogeneic Stem CellsAutologous Stem cells

By Applications:Veterinary HospitalsVeterinary ClinicsVeterinary Research Institutes

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Global Canine Stem Cell Therapy Market 2027 Register a Xx% CAGR In Terms Of Revenue: VETSTEM BIOPHARMA, Cell Therapy Sciences, Regeneus, Aratana...

Coronavirus Drug and Treatment Tracker – The New York Times

The Covid-19 pandemic is one of the greatest challenges modern medicine has ever faced. Doctors and scientists are scrambling to find treatments and drugs that can save the lives of infected people and perhaps even prevent them from getting sick in the first place.

Below is an updated list of 20 of the most-talked-about treatments for the coronavirus. While some are accumulating evidence that theyre effective, most are still at early stages of research. We also included a warning about a few that are just bunk.

We are following 20 coronavirus treatments for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

Tentative or

mixed evidence

We are following 20 coronavirus treatments

for effectiveness and safety:

There is no cure yet for Covid-19. And even the most promising treatments to date only help certain groups of patients and await validation from further trials. The F.D.A. has not fully licensed any treatment specifically for the coronavirus. Although it has granted emergency use authorization to some treatments, their effectiveness against Covid-19 has yet to be demonstrated in large-scale, randomized clinical trials.

This list provides a snapshot of the latest research on the coronavirus, but does not constitute medical endorsements. Always consult your doctor about treatments for Covid-19.

New additions and recent updates:

Added ivermectin, a drug typically used against parasitic worms that is being increasingly prescribed in Latin America. Aug. 10

Updated descriptions for several treatments. Aug. 10

We will update and expand the list as new evidence emerges. For details on evaluating treatments, see the N.I.H. Covid-19 Treatment Guidelines. For the current status of vaccine development, see our Coronavirus Vaccine Tracker.

WIDELY USED: These treatments have been used widely by doctors and nurses to treat patients hospitalized for diseases that affect the respiratory system, including Covid-19.

PROMISING EVIDENCE: Early evidence from studies on patients suggests effectiveness, but more research is needed. This category includes treatments that have shown improvements in morbidity, mortality and recovery in at least one randomized controlled trial, in which some people get a treatment and others get a placebo.

TENTATIVE OR MIXED EVIDENCE: Some treatments show promising results in cells or animals, which need to be confirmed in people. Others have yielded encouraging results in retrospective studies in humans, which look at existing datasets rather than starting a new trial. Some treatments have produced different results in different experiments, raising the need for larger, more rigorously designed studies to clear up the confusion.

NOT PROMISING: Early evidence suggests that these treatments do not work.

PSEUDOSCIENCE OR FRAUD: These are not treatments that researchers have ever considered using for Covid-19. Experts have warned against trying them, because they do not help against the disease and can instead be dangerous. Some people have even been arrested for their false promises of a Covid-19 cure.

EVIDENCE IN CELLS, ANIMALS or HUMANS: These labels indicate where the evidence for a treatment comes from. Researchers often start out with experiments on cells and then move onto animals. Many of those animal experiments often fail; if they dont, researchers may consider moving on to research on humans, such as retrospective studies or randomized clinical trials. In some cases, scientists are testing out treatments that were developed for other diseases, allowing them to move directly to human trials for Covid-19.

All treatmentsWidely usedPromisingTentative or mixedNot promisingPseudoscience

Antivirals can stop viruses such as H.I.V. and hepatitis C from hijacking our cells. Scientists are searching for antivirals that work against the new coronavirus.

PROMISING EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSEMERGENCY USE AUTHORIZATIONRemdesivirRemdesivir, made by Gilead Sciences, was the first drug to get emergency authorization from the F.D.A. for use on Covid-19. It stops viruses from replicating by inserting itself into new viral genes. Remdesivir was originally tested as an antiviral against Ebola and Hepatitis C, only to deliver lackluster results. But preliminary data from trials that began this spring suggested the drug can reduce the recovery time of people hospitalized with Covid-19 from 15 to 11 days. (The study defined recovery as either discharge from the hospital or hospitalization for infection-control purposes only.) These early results did not show any effect on mortality, though retrospective data released in July hints that the drug might reduce death rates among those who are very ill.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSFavipiravirOriginally designed to beat back influenza, favipiravir blocks a viruss ability to copy its genetic material. A small study in March indicated the drug might help purge the coronavirus from the airway, but results from larger, well-designed clinical trials are still pending.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMK-4482Another antiviral originally designed to fight the flu, MK-4482 (previously known as EIDD-2801) has had promising results against the new coronavirus in studies in cells and on animals. Merck, which has been running clinical trials on the drug this summer, has announced it will launch a large Phase III trial in September.Updated Aug. 6

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS Recombinant ACE-2To enter cells, the coronavirus must first unlock them a feat it accomplishes by latching onto a human protein called ACE-2. Scientists have created artificial ACE-2 proteins which might be able to act as decoys, luring the coronavirus away from vulnerable cells. Recombinant ACE-2 proteins have shown promising results in experiments on cells, but not yet in animals or people.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS IvermectinFor decades, ivermectin has served as a potent drug to treat parasitic worms. Doctors use it against river blindness and other diseases, while veterinarians give dogs a different formulation to cure heartworm. Studies on cells have suggested ivermectin might also kill viruses. But scientists have yet to find evidence in animal studies or human trials that it can treat viral diseases. As a result, Ivermectin is not approved to use as an antiviral.

In April, Australian researchers reported that the drug blocked coronaviruses in cell cultures, but they used a dosage that was so high it might have dangerous side effects in people. The FDA immediately issued a warning against taking pet medications to treat or prevent Covid-19. These animal drugs can cause serious harm in people, the agency warned.

Since then a number of clinical trials have been launched to see if a safe dose of ivermectin can fight Covid-19. In Singapore, for example, the National University Hospital is running a 5,000-person trial to see if it can prevent people from getting infected. As of now, theres no firm evidence that it works. Nevertheless ivermectin is being prescribed increasingly often in Latin America, much to the distress of disease experts.Updated Aug. 10

NOT PROMISING EVIDENCE IN CELLS AND HUMANS Lopinavir and ritonavirTwenty years ago, the F.D.A. approved this combination of drugs to treat H.I.V. Recently, researchers tried them out on the new coronavirus and found that they stopped the virus from replicating. But clinical trials in patients proved disappointing. In early July, the World Health Organization suspended trials on patients hospitalized for Covid-19. They didnt rule out studies to see if the drugs could help patients not sick enough to be hospitalized, or to prevent people exposed to the new coronavirus from falling ill. The drug could also still have a role to play in certain combination treatments.

NOT PROMISING EVIDENCE IN CELLS, ANIMALS AND HUMANSHydroxychloroquine and chloroquineGerman chemists synthesized chloroquine in the 1930s as a drug against malaria. A less toxic version, called hydroxychloroquine, was invented in 1946, and later was approved for other diseases such as lupus and rheumatoid arthritis. At the start of the Covid-19 pandemic, researchers discovered that both drugs could stop the coronavirus from replicating in cells.

Since then, theyve had a tumultuous ride. A few small studies on patients offered some hope that hydroxychloroquine could treat Covid-19. The World Health Organization launched a randomized clinical trial in March to see if it was indeed safe and effective for Covid-19, as did Novartis and a number of universities. Meanwhile, President Trump repeatedly promoted hydroxychloroquine at press conferences, touting it as a game changer, and even took it himself. The F.D.A. temporarily granted hydroxychloroquine emergency authorization for use in Covid-19 patients which a whistleblower later claimed was the result of political pressure. In the wake of the drugs newfound publicity, demand spiked, resulting in shortages for people who rely on hydroxychloroquine as a treatment for other diseases.

But more detailed studies proved disappointing. A study on monkeys found that hydroxychloroquine didnt prevent the animals from getting infected and didnt clear the virus once they got sick. Randomized clinical trials found that hydroxychloroquine didnt help people with Covid-19 get better or prevent healthy people from contracting the coronavirus. Another randomized clinical trial found that giving hydroxychloroquine to people right after being diagnosed with Covid-19 didnt reduce the severity of their disease. (One large-scale study that concluded the drug was harmful as well was later retracted.) The World Health Organization, the National Institutes of Health and Novartis have since halted trials investigating hydroxychloroquine as a treatment for Covid-19, and the F.D.A. revoked its emergency approval. The F.D.A. now warns that the drug can cause a host of serious side effects to the heart and other organs when used to treat Covid-19.

In July, researchers at Henry Ford hospital in Detroit published a study finding that hydroxychloroquine was associated with a reduction in mortality in Covid-19 patients. President Trump praised the study on Twitter, but experts raised doubts about it. The study was not a randomized controlled trial, in which some people got a placebo instead of hydroxychloroquine. The studys results might not be due to the drug killing the virus. Instead, doctors may have given the drug to people who were less sick, and thus more likely to recover anyway.

Despite negative results, a number of hydroxychloroquine trials have continued, although most are small, testing a few dozen or a few hundred patients. A recent analysis by STAT and Applied XL found more than 180 ongoing clinical trials testing hydroxychloroquine or chloroquine, for treating or preventing Covid-19. Although its clear the drugs are no panacea, its theoretically possible they could provide some benefit in combination with other treatments, or when given in early stages of the disease. Only well-designed trials can determine if thats the case.Updated Aug. 10

Most people who get Covid-19 successfully fight off the virus with a strong immune response. Drugs might help people who cant mount an adequate defense.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS AND HUMANS Convalescent plasmaA century ago, doctors filtered plasma from the blood of recovered flu patients. So-called convalescent plasma, rich with antibodies, helped people sick with flu fight their illness. Now researchers are trying out this strategy on Covid-19. In May, the F.D.A. designated convalescent plasma an investigational product. That means that despite not yet being shown as safe and effective, plasma can be used in clinical trials and given to some patients who are seriously ill with Covid-19. Tens of thousands of patients in the U.S. have received plasma through a program launched by the Mayo Clinic and the federal government.

The Trump administration has praised convalescent plasma, despite the lack of evidence yet that it works. The first wave of trials have been small and the results have been mixed. Large randomized clinical trials are underway, but theyve struggled to enroll enough participants, some of whom worry they will receive a placebo instead of the treatment itself.

Experts say that its vital to complete these trials to determine if convalescent plasma is safe and effective. If these trials are successful, it could serve as an important stopgap measure until more potent therapies become widely available.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSMonoclonal antibodiesConvalescent plasma from people who recover from Covid-19 contains a mix of different antibodies. Some of the molecules can attack the coronavirus, but many are directed at other pathogens. Researchers have sifted through this slurry to find the most potent antibodies against Covid-19. They have then manufactured synthetic copies of these molecules, known as monoclonal antibodies. Researchers have begun investigating them as a treatment for Covid-19, either individually or in cocktails.

Monoclonal antibodies were first developed as a therapy in the 1970s, and since then the F.D.A. has approved them for 79 diseases, ranging from cancer to AIDS. Since the start of the pandemic, researchers have found dozens of monoclonal antibodies that show promise against Covid-19 in preclinical studies on cells and animals. Companies like Eli Lilly and Regeneron recently began clinical trials studying monoclonal antibodies. Several other firms, as well as teams at universities, are slated to enter the race soon as well.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN CELLS, ANIMALS AND HUMANSInterferonsInterferons are molecules our cells naturally produce in response to viruses. They have profound effects on the immune system, rousing it to attack the invaders, while also reining it in to avoid damaging the bodys own tissues. Injecting synthetic interferons is now a standard treatment for a number of immune disorders. Rebif, for example, is prescribed for multiple sclerosis.

As part of its strategy to attack our bodies, the coronavirus appears to tamp down interferon. That finding has encouraged researchers to see whether a boost of interferon might help people weather Covid-19, particularly early in infection. Early studies, including experiments in cells and mice, have yielded encouraging results that have led to clinical trials.

An open-label study in China suggested that the molecules could help prevent healthy people from getting infected. On July 20, the British pharmaceutical company Synairgen announced that an inhaled form of interferon called SNG001 lowered the risk of severe Covid-19 in infected patients in a small clinical trial. The full data have not yet been released to the public, or published in a scientific journal. On August 6, the National Institute of Allergy and Infectious Diseases launched a Phase III trial on a combination of Rebif and the antiviral remdesivir, with results expected by fall 2020.Updated Aug. 10

The most severe symptoms of Covid-19 are the result of the immune systems overreaction to the virus. Scientists are testing drugs that can rein in its attack.

PROMISING EVIDENCE EVIDENCE IN HUMANS DexamethasoneThis cheap and widely available steroid blunts many types of immune responses. Doctors have long used it to treat allergies, asthma and inflammation. In June, it became the first drug shown to reduce Covid-19 deaths. That study of more than 6,000 people, which in July was published in the New England Journal of Medicine, found that dexamethasone reduced deaths by one-third in patients on ventilators, and by one-fifth in patients on oxygen. It may be less likely to help and may even harm patients who are at an earlier stage of Covid-19 infections, however. In its Covid-19 treatment guidelines, the National Institutes of Health recommends only using dexamethasone in patients with COVID-19 who are on a ventilator or are receiving supplemental oxygen.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Cytokine InhibitorsThe body produces signaling molecules called cytokines to fight off diseases. But manufactured in excess, cytokines can trigger the immune system to wildly overreact to infections, in a process sometimes called a cytokine storm. Researchers have created a number of drugs to halt cytokine storms, and they have proven effective against arthritis and other inflammatory disorders. Some turn off the supply of molecules that launch the production of the cytokines themselves. Others block the receptors on immune cells to which cytokines would normally bind. A few block the cellular messages they send. Depending on how the drugs are formulated, they can block one cytokine at a time, or muffle signals from several at once.

Against the coronavirus, several of these drugs have offered modest help in some trials, but faltered in others. Drug companies Regeneron and Roche drug both recently announced that two drugs called sarilumab and tocilizumab, which both target the cytokine IL-6, did not appear to benefit patients in Phase 3 clinical trials. Many other trials remain underway, several of which combine cytokine inhibitors with other treatments.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS EMERGENCY USE AUTHORIZATIONBlood filtration systemsThe F.D.A. has granted emergency use authorization to several devices that filter cytokines from the blood in an attempt to cool cytokine storms. One machine, called Cytosorb, can reportedly purify a patients entire blood supply about 70 times in a 24-hour period. A small study in March suggested that Cytosorb had helped dozens of severely ill Covid-19 patients in Europe and China, but it was not a randomized clinical trial that could conclusively demonstrate it was effective. A number of studies on blood filtration systems are underway, but experts caution that these devices carry some risks. For example, such filters could remove beneficial components of blood as well, such as vitamins or medications.Updated Aug. 10

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS Stem cellsCertain kinds of stem cells can secrete anti-inflammatory molecules. Over the years, researchers have tried to use them as a treatment for cytokine storms, and now dozens of clinical trials are under way to see if they can help patients with Covid-19. But these stem cell treatments havent worked well in the past, and its not clear yet if theyll work against the coronavirus.

Doctors and nurses often administer other supportive treatments to help patients with Covid-19.

WIDELY USEDProne positioningThe simple act of flipping Covid-19 patients onto their bellies opens up the lungs. The maneuver has become commonplace in hospitals around the world since the start of the pandemic. It might help some individuals avoid the need for ventilators entirely. The treatments benefits continue to be tested in a range of clinical trials.

WIDELY USEDEMERGENCY USE AUTHORIZATIONVentilators and other respiratory support devicesDevices that help people breathe are an essential tool in the fight against deadly respiratory illnesses. Some patients do well if they get an extra supply of oxygen through the nose or via a mask connected to an oxygen machine. Patients in severe respiratory distress may need to have a ventilator breathe for them until their lungs heal. Doctors are divided about how long to treat patients with noninvasive oxygen before deciding whether or not they need a ventilator. Not all Covid-19 patients who go on ventilators survive, but the devices are thought to be lifesaving in many cases.

TENTATIVE OR MIXED EVIDENCE EVIDENCE IN HUMANS AnticoagulantsThe coronavirus can invade cells in the lining of blood vessels, leading to tiny clots that can cause strokes and other serious harm. Anticoagulants are commonly used for other conditions, such as heart disease, to slow the formation of clots, and doctors sometimes use them on patients with Covid-19 who have clots. Many clinical trials teasing out this relationship are now underway. Some of these trials are looking at whether giving anticoagulants before any sign of clotting is beneficial.

False claims about Covid-19 cures abound. The F.D.A. maintains a list of more than 80 fraudulent Covid-19 products, and the W.H.O. debunks many myths about the disease.

WARNING: DO NOT DO THISDrinking or injecting bleach and disinfectantsIn April, President Trump suggested that disinfectants such as alcohol or bleach might be effective against the coronavirus if directly injected into the body. His comments were immediately refuted by health professionals and researchers around the world as well as the makers of Lysol and Clorox. Ingesting disinfectant would not only be ineffective against the virus, but also hazardous possibly even deadly. In July, Federal prosecutors charged four Florida men with marketing bleach as a cure for COVID-19.

WARNING: NO EVIDENCEUV lightPresident Trump also speculated about hitting the body with ultraviolet or just very powerful light. Researchers have used UV light to sterilize surfaces, including killing viruses, in carefully managed laboratories. But UV light would not be able to purge the virus from within a sick persons body. This kind of radiation can also damage the skin. Most skin cancers are a result of exposure to the UV rays naturally present in sunlight.

WARNING: NO EVIDENCESilverThe F.D.A. has threatened legal action against a host of people claiming silver-based products are safe and effective against Covid-19 including televangelist Jim Bakker and InfoWars host Alex Jones. Several metals do have natural antimicrobial properties. But products made from them have not been shown to prevent or treat the coronavirus.

Note: After additional discussions with experts we have adjusted several labels on the tracker. The Strong evidence label has been removed until further research identifies treatments that consistently benefit groups of patients infected by the coronavirus. In its place, Promising evidence will be used for drugs such as remdesivir and dexamethasone that have shown promise in at least one randomized controlled trial, and Widely used for treatments such as proning and ventilators that are often used with severely ill patients, including those with Covid-19. And we may reintroduce the Ineffective label when ongoing clinical trials repeatedly end with disappointing results.

Sources: National Library of Medicine; National Institutes of Health; William Amarquaye, University of South Florida; Paul Bieniasz, Rockefeller University; Jeremy Faust, Brigham & Womens Hospital; Matt Frieman, University of Maryland School of Medicine; Noah Haber, Stanford University; Swapnil Hiremath, University of Ottawa; Akiko Iwaskai, Yale University; Paul Knoepfler, University of California, Davis; Elena Massarotti, Brigham and Womens Hospital; John Moore and Douglas Nixon, Weill Cornell Medical College; Erica Ollman Saphire, La Jolla Institute for Immunology; Regina Rabinovich, Harvard T.H. Chan School of Public Health; Ilan Schwartz, University of Alberta; Phyllis Tien, University of California, San Francisco.

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Coronavirus Drug and Treatment Tracker - The New York Times

Sick of sourdough bread yet? 5 sourdough dishes beyond the basic loaf: empanadas, waffles, popovers, crepes and crackers – San Antonio Express-News

Continued here:
Sick of sourdough bread yet? 5 sourdough dishes beyond the basic loaf: empanadas, waffles, popovers, crepes and crackers - San Antonio Express-News

At the onset of the COVID-19 outbreak, the coronavirus wasnt the only bug America became obsessed with. Practically overnight, seemingly every American now flush with time and boredom started to bake sourdough bread.

Flour and yeast disappeared from grocery store shelves. Boundless boules and batards both popular sourdough loaf shapes spread faster than any virus on countless social media threads. Home baked bread was back, and in a big way.

But like any new lifestyle we love to crow about on social media a new fitness routine, the Whole30 challenge, selling essential oils beginners enthusiasm sometimes outstripped the reality of the commitment that keeping sourdough starter alive demands. Many ghosted on their bready crush, seeking fulfillment elsewhere. But for a lucky masochistic few, a lifelong passion ignited.

I killed my starter twice. It really was like feeding a pet, said Katie Kinder DeBauche, the vice president of development at the Witte Museum. She was working from home and had played with sourdough a few times before.

She named her starter Dolores after the Westworld character Dolores Abernathy, whos known for regenerating multiple times after death. Kinder DeBauche, made sure to keep a portion of Dolores as a backup in the fridge just in case. Id forget about her on the counter. Shes been reincarnated twice.

On ExpressNews.com: Sourdough is back, connecting new generations of bakers with starters decades old

San Antonio chef Dave Terrazas found himself laid off from his job with Mercy Chefs and getting familiar with yeast, flour and water at the onset of the coronavirus outbreak as well. From March into the early summer, Terrazas could be found in his kitchen stirring, kneading and baking up loaves of sourdough bread. Hed had an on-again-off-again relationship with sourdough before the pandemic.

But his efforts went onto a back burner once the heat cranked up. His starter, which never received a name, has passed on to the great, bubbly beyond.

Once the garden season went into full swing around May, that was just so time consuming, Terrazas said. He helped plant about a half-dozen gardens for himself and fellow culinary professionals. The camaraderie and fun of building gardens kind of took over.

For both, the sourdough adventure led to learning a lot about bread and what else sourdough starter can become.

The sourdough starter feeding process involves generating a considerable quantity of what bakers often call discard, or a portion of starter thats no longer needed after a fresh feeding. That discard is loaded with a wide range of flavorful and aromatic bacteria and yeast. Many bakers throw it out, but that discard can be used to make countless other things.

Kinder DeBauche said she hated that waste, so she looked for recipes that went beyond the basic loaf.

On ExpressNews.com: No-knead bread still the king of viral recipes

The best and worst thing that happened to me during the quarantine is sourdough waffles. Its not so much the waffle thats bad for you, but what you put on them, she said with a laugh.

Terrazas also found the sourdough discard to be the biggest revelation of his quarantine baking efforts.

Waste not, want not, Terrazas said. It would be a shame wasting a cup or 2 every day. It has all those flavors in it. That flavorful waste product became waffles, empanadas, pasta and more in his kitchen.

Pasta, Terrazas said, was particularly interesting. Typically, pasta doesnt contain any yeast or other leavening agents. The starter, he said, gave his noodles a bounce similar to traditional ramen noodles, which are cooked in water containing one of several kinds of alkaline salt to achieve their unique texture.

On ExpressNews.com: 4 oven-free icebox pies: Margarita, chocolate, lemon and dulce de leche

Playing with sourdough gave both Terrazas and Kinder DeBauche other creative and professional outlets, as well.

For Kinder DeBauche, baking became a way to connect with her family. Her great grandparents were immigrant bakers from Poland who settled in New Jersey. Shes documented the process of teaching herself to bake on her blog at katiesmidnightbaker.com. Shes also turned her baking exploits into a side hustle selling batches of Parker House rolls made from her familys secret recipe.

Terrazas saw sourdough as a perfect educational vehicle. In the coming weeks he plans to launch an online program called Foodie Classroom. The website, foodieclassroom.com, will go live in coming weeks.

Foodie Classroom will take the state standards for all the STEM classes and use food as a contextual element. Algebra can be used to upscale a recipe. Geometry can be used to calculate the area of a pizza. Terrazas explained. Ill be filming videos in farms, gardens, parks and kitchens around the city.

And sourdough will play a roll in that education.

Part of the reason for the whole sourdough thing was Foodie Classroom, he said. Ninth grade biology is all about the life cycle of cells.

If, like Terrazas and Kinder DeBauche, you want options for what to do with the starter discard, were providing you with some sourdough recipes that go beyond the basic loaf.

Recipe: Sourdough Waffles

Recipe: Sourdough Empanadas

Recipe: Sourdough Popovers

Recipe: Sourdough Crepes

Recipe: Sourdough Crackers

Recipe: Sourdough Starter

Paul Stephen is a food and drink reporter and restaurant critic in the San Antonio and Bexar County area. To read more from Paul, become a subscriber. pstephen@express-news.net | Twitter: @pjbites | Instagram: @pjstephen

Veterinary Scholars Symposium Showcases Veterinary Talent And Highlights Need For Continued Innovation In Advancing Animal And Human Health -…

http://www.boehringer-ingelheim.us

DULUTH, Ga., Aug. 6, 2020 /PRNewswire/ --More than 500 veterinary students from across the U.S., as well as animal health researchers and leaders from three dozen top veterinary schools, convened virtually this week for the Veterinary Summer Scholars Symposium and presentation of the annual Boehringer Ingelheim Research Awards for Graduate Veterinarians and Veterinary Students.

This annual scientific colloquium normally conducted in person -- showcases research by veterinary students completing summer research internships. It provides an opportunity for students in the Boehringer Ingelheim Veterinary Scholars Program to present and discuss research findings. Veterinary Scholars also have the opportunity to network with each other and with mentors from academia, industry and government.

The Boehringer Ingelheim Veterinary Scholars Program was established more than 30 years ago to introduce first- and second-year veterinary medical students to biomedical research. Nearly 4,000 students have received stipends from Boehringer Ingelheim to conduct research since the program started. More information is available at http://veterinaryscholars.boehringer-ingelheim.com/.

At each participating school, Boehringer Ingelheim Veterinary Scholars are assigned a mentor and laboratory. Each scholar conducts a hypothesis-driven research project. The research project is typically conducted over a 10-12 week period during the summer, with students presenting their work at the conclusion. This year, the 35 participating schools quickly deployed alternative plans to comply with COVID-19 safety measures. Some offered lab-based projects to students in a way that provided social distancing and related protections. Others refocused students' research work on projects involving data analysis, which could be conducted offsite.

"We hope that some good can come from the many lessons we have learned during this year's pandemic, such that we can better detect and treat -- or even prevent -- the next pandemic or major threat to human and animal health," said Caroline Belmont, head of U.S. Animal Health Innovation for Boehringer Ingelheim. "Recent events have highlighted how important both innovation and collaboration are in addressing unmet needs in animal and human health. We look forward to the many future contributions today's veterinary students and researchers will make in advancing these efforts."

Students from the more than three dozen veterinary schools participating in the Veterinary Scholars Program are eligible to apply for two annual awards: The Boehringer Ingelheim Veterinary Graduate Award and the Veterinary Research Scholar Award. Winning students receive monetary prizes and a stipend to attend the annual Veterinary Scholars Symposium to accept their awards and present their research.

The 2020 Boehringer Ingelheim Veterinary Graduate Award was presented at the virtual Veterinary Scholars Symposium to Dr. Sara Hamman Osum, a graduate student completing her Ph.D. in the Comparative and Molecular Biosciences Graduate Program at the University of Minnesota's College of Veterinary Medicine.

Dr. Osum's Ph.D. research has focused on developing and characterizing the first porcine model of Neurofibromatosis type 1 (NF1), a devastating neurologic disease for which there is no cure. Before joining the DVM/PhD program at the University of Minnesota, she spent four years as a research associate, studying tolerance and autoimmunity models and fostering her interest in advancing animal welfare through the development of improved animal models for preclinical research. Dr. Osum received her Doctor of Veterinary Medicine from the University of Minnesota in 2016, and her Bachelor of Science in Biology from the University of California in Santa Cruz, Calif., in 2008.

The Boehringer Ingelheim Veterinary Graduate Award promotes research in veterinary biosciences. It recognizes graduate veterinarians who have completed or will soon complete a Ph.D. program or are in their final years of residency training in veterinary pathology, medicine, surgery, radiology/ imaging, or laboratory animal medicine. Recipients receive an honorarium and are invited to present their research at the annual Veterinary Scholars Symposium.

The recipient of the 2020 Boehringer Ingelheim Veterinary Research Scholar Awardis Megan Fahey, a DVM and Ph.D. degree student at Cornell University's College of Veterinary Medicine. Fahey is committed to a career as a veterinary clinician scientist, and her research interests have evolved to focus on zoonotic disease, virology, and immunology. Her work in the Boehringer Ingelheim Veterinary Scholars Program has involved exploration of the use of mesenchymal stem cells to prevent or reduce degeneration in intervertebral disc disease.

Caroline Schlaeppi Fisher, from North Carolina State University's College of Veterinary Medicine, received an honorable mention, 2020Boehringer Ingelheim Veterinary Research Scholar. That distinction recognizes herwork evaluating the effectiveness of reuse and sterilization of certain devices used in veterinary surgery, work intended to help shape evidence-based guidelines for the reuse of these devices.

Boehringer Ingelheim Animal Health The lives of animals and humans are interconnected in deep and complex ways. We know that when animals are healthy, humans are healthier too. Across the globe, our 10,000 employees are dedicated to delivering value through innovation, thus enhancing the well-being of both.

Respect for animals, humans and the environment is at the heart of what we do. We develop solutions and provide services to protect animals from disease and pain. We support our customers in taking care of the health of their animals and protect our communities against life- and society- threatening diseases.

Boehringer Ingelheim Animal Health is the second largest animal health business in the world, with net sales of $4.5 billion (4 billion euros) in 2019 and presence in more than 150 countries.

Boehringer Ingelheim Animal Health has a significant presence in the United States, with more than 3,100 employees in places that include Georgia, Missouri, Iowa, Minnesota, New Jersey and Puerto Rico. To learn more, visit http://www.boehringer-ingelheim.us, http://www.facebook.com/BoehringerAHUS or http://www.twitter.com/Boehringer_AH.

Boehringer Ingelheim Making new and better medicines for humans and animals is at the heart of what we do. Our mission is to create breakthrough therapies that change lives. Since its founding in 1885, Boehringer Ingelheim has been independent and family-owned. We have the freedom to pursue our long-term vision, looking ahead to identify the health challenges of the future and targeting those areas of need where we can do the most good.

As a world-leading, research-driven pharmaceutical company, more than 51,000 employees create value through innovation daily for our three business areas: Human Pharma, Animal Health, and Biopharmaceutical Contract Manufacturing.

In 2019, Boehringer Ingelheim achieved net sales of $21.3 billion (19 billion euros). Our significant investment of over $3.9 billion (3.5 billion euros) in R&D drives innovation, enabling the next generation of medicines that save lives and improve quality of life.

We realize more scientific opportunities by embracing the power of partnership and diversity of experts across the life-science community. By working together, we accelerate the delivery of the next medical breakthrough that will transform the lives of patients now, and in generations to come.

More information about Boehringer Ingelheim can be found at http://www.boehringer-ingelheim.com or in our annual report: http://annualreport.boehringer-ingelheim.com.

SOURCE Boehringer Ingelheim Animal Health USA Inc.

Biotechnology Could Change the Cattle Industry. Will it Succeed? – Undark Magazine

When Ralph Fisher, a Texas cattle rancher, set eyes on one of the worlds first cloned calves in August 1999, he didnt care what the scientists said: He knew it was his old Brahman bull, Chance, born again. About a year earlier, veterinarians at Texas A&M extracted DNA from one of Chances moles and used the sample to create a genetic double. Chance didnt live to meet his second self, but when the calf was born, Fisher christened him Second Chance, convinced he was the same animal.

Scientists cautioned Fisher that clones are more like twins than carbon copies: The two may act or even look different from one another. But as far as Fisher was concerned, Second Chance was Chance. Not only did they look identical from a certain distance, they behaved the same way as well. They ate with the same odd mannerisms; laid in the same spot in the yard. But in 2003, Second Chance attacked Fisher and tried to gore him with his horns. About 18 months later, the bull tossed Fisher into the air like an inconvenience and rammed him into the fence. Despite 80 stitches and a torn scrotum, Fisher resisted the idea that Second Chance was unlike his tame namesake, telling the radio program This American Life that I forgive him, you know?

In the two decades since Second Chance marked a genetic engineering milestone, cattle have secured a place on the front lines of biotechnology research. Today, scientists around the world are using cutting-edge technologies, from subcutaneous biosensors to specialized food supplements, in an effort to improve safety and efficiency within the $385 billion global cattle meat industry. Beyond boosting profits, their efforts are driven by an imminent climate crisis, in which cattle play a significant role, and growing concern for livestock welfare among consumers.

Gene editing stands out as the most revolutionary of these technologies. Although gene-edited cattle have yet to be granted approval for human consumption, researchers say tools like Crispr-Cas9 could let them improve on conventional breeding practices and create cows that are healthier, meatier, and less detrimental to the environment. Cows are also being given genes from the human immune system to create antibodies in the fight against Covid-19. (The genes of non-bovine livestock such as pigs and goats, meanwhile, have been hacked to grow transplantable human organs and produce cancer drugs in their milk.)

But some experts worry biotech cattle may never make it out of the barn. For one thing, theres the optics issue: Gene editing tends to grab headlines for its role in controversial research and biotech blunders. Crispr-Cas9 is often celebrated for its potential to alter the blueprint of life, but that enormous promise can become a liability in the hands of rogue and unscrupulous researchers, tempting regulatory agencies to toughen restrictions on the technologys use. And its unclear how eager the public will be to buy beef from gene-edited animals. So the question isnt just if the technology will work in developing supercharged cattle, but whether consumers and regulators will support it.

Cattle are catalysts for climate change. Livestock account for an estimated 14.5 percent of greenhouse gas emissions from human activities, of which cattle are responsible for about two thirds, according to the United Nations Food and Agriculture Organization (FAO). One simple way to address the issue is to eat less meat. But meat consumption is expected to increase along with global population and average income. A 2012 report by the FAO projected that meat production will increase by 76 percent by 2050, as beef consumption increases by 1.2 percent annually. And the United States is projected to set a record for beef production in 2021, according to the Department of Agriculture.

For Alison Van Eenennaam, an animal geneticist at the University of California, Davis, part of the answer is creating more efficient cattle that rely on fewer resources. According to Van Eenennaam, the number of dairy cows in the United States decreased from around 25 million in the 1940s to around 9 million in 2007, while milk production has increased by nearly 60 percent. Van Eenennaam credits this boost in productivity to conventional selective breeding.

You dont need to be a rocket scientist or even a mathematician to figure out that the environmental footprint or the greenhouse gases associated with a glass of milk today is about one-third of that associated with a glass of milk in the 1940s, she says. Anything you can do to accelerate the rate of conventional breeding is going to reduce the environmental footprint of a glass of milk or a pound of meat.

Modern gene-editing tools may fuel that acceleration. By making precise cuts to DNA, geneticists insert or remove naturally occurring genes associated with specific traits. Some experts insist that gene editing has the potential to spark a new food revolution.

The question isnt just if the technology will work in developing supercharged cattle, but whether consumers and regulators will support it.

Jon Oatley, a reproductive biologist at Washington State University, wants to use Crispr-Cas9 to fine tune the genetic code of rugged, disease-resistant, and heat-tolerant bulls that have been bred to thrive on the open range. By disabling a gene called NANOS2, he says he aims to eliminate the capacity for a bull to make his own sperm, turning the recipient into a surrogate for sperm-producing stem cells from more productive prized stock. These surrogate sires, equipped with sperm from prize bulls, would then be released into range herds that are often genetically isolated and difficult to access, and the premium genes would then be transmitted to their offspring.

Furthermore, surrogate sires would enable ranchers to introduce desired traits without having to wrangle their herd into one place for artificial insemination, says Oatley. He envisions the gene-edited bulls serving herds in tropical regions like Brazil, the worlds largest beef exporter and home to around 200 million of the approximately 1.5 billion head of cattle on Earth.

Brazils herds are dominated by Nelore, a hardy breed that lacks the carcass and meat quality of breeds like Angus but can withstand high heat and humidity. Put an Angus bull on a tropical pasture and hes probably going to last maybe a month before he succumbs to the environment, says Oatley, while a Nelore bull carrying Angus sperm would have no problem with the climate.

The goal, according to Oatley, is to introduce genes from beefier bulls into these less efficient herds, increasing their productivity and decreasing their overall impact on the environment. We have shrinking resources, he says, and need new, innovative strategies for making those limited resources last.

Oatley has demonstrated his technique in mice but faces challenges with livestock. For starters, disabling NANOS2 does not definitively prevent the surrogate bull from producing some of its own sperm. And while Oatley has shown he can transplant sperm-producing cells into surrogate livestock, researchers have not yet published evidence showing that the surrogates produce enough quality sperm to support natural fertilization. How many cells will you need to make this bull actually fertile? asks Ina Dobrinski, a reproductive biologist at the University of Calgary who helped pioneer germ cell transplantation in large animals.

But Oatleys greatest challenge may be one shared with others in the bioengineered cattle industry: overcoming regulatory restrictions and societal suspicion. Surrogate sires would be classified as gene-edited animals by the Food and Drug Administration, meaning theyd face a rigorous approval process before their offspring could be sold for human consumption. But Oatley maintains that if his method is successful, the sperm itself would not be gene-edited, nor would the resulting offspring. The only gene-edited specimens would be the surrogate sires, which act like vessels in which the elite sperm travel.

Even so, says Dobrinski, Thats a very detailed difference and Im not sure how that will work with regulatory and consumer acceptance.

In fact, American attitudes towards gene editing have been generally positive when the modification is in the interest of animal welfare. Many dairy farmers prefer hornless cows horns can inflict damage when wielded by 1,500-pound animals so they often burn them off in a painful process using corrosive chemicals and scalding irons. In a study published last year in the journal PLOS One, researchers found that most Americans are willing to consume food products from cows genetically modified to be hornless.

Still, experts say several high-profile gene-editing failures in livestock and humans in recent years may lead consumers to consider new biotechnologies to be dangerous and unwieldy.

In 2014, a Minnesota startup called Recombinetics, a company with which Van Eenennaams lab has collaborated, created a pair of cross-bred Holstein bulls using the gene-editing tool TALENs, a precursor to Crispr-Cas9, making cuts to the bovine DNA and altering the genes to prevent the bulls from growing horns. Holstein cattle, which almost always carry horned genes, are highly productive dairy cows, so using conventional breeding to introduce hornless genes from less productive breeds can compromise the Holsteins productivity. Gene editing offered a chance to introduce only the genes Recombinetics wanted. Their hope was to use this experiment to prove that milk from the bulls female progeny was nutritionally equivalent to milk from non-edited stock. Such results could inform future efforts to make Holsteins hornless but no less productive.

The experiment seemed to work. In 2015, Buri and Spotigy were born. Over the next few years, the breakthrough received widespread media coverage, and when Buris hornless descendant graced the cover of Wired magazine in April 2019, it did so as the ostensible face of the livestock industrys future.

But early last year, a bioinformatician at the FDA ran a test on Buris genome and discovered an unexpected sliver of genetic code that didnt belong. Traces of bacterial DNA called a plasmid, which Recombinetics used to edit the bulls genome, had stayed behind in the editing process, carrying genes linked to antibiotic resistance in bacteria. After the agency published its findings, the media reaction was swift and fierce: FDA finds a surprise in gene-edited cattle: antibiotic-resistant, non-bovine DNA, read one headline. Part cow, part bacterium? read another.

Recombinetics has since insisted that the leftover plasmid DNA was likely harmless and stressed that this sort of genetic slipup is not uncommon.

Is there any risk with the plasmid? I would say theres none, says Tad Sonstegard, president and CEO of Acceligen, a Recombinetics subsidiary. We eat plasmids all the time, and were filled with microorganisms in our body that have plasmids. In hindsight, Sonstegard says his teams only mistake was not properly screening for the plasmid to begin with.

While the presence of antibiotic-resistant plasmid genes in beef probably does not pose a direct threat to consumers, according to Jennifer Kuzma, a professor of science and technology policy and co-director of the Genetic Engineering and Society Center at North Carolina State University, it does raise the possible risk of introducing antibiotic-resistant genes into the microflora of peoples digestive systems. Although unlikely, organisms in the gut could integrate those genes into their own DNA and, as a result, proliferate antibiotic resistance, making it more difficult to fight off bacterial diseases.

The lesson that I think is learned there is that science is never 100 percent certain, and that when youre doing a risk assessment, having some humility in your technology product is important, because you never know what youre going to discover further down the road, she says. In the case of Recombinetics. I dont think there was any ill intent on the part of the researchers, but sometimes being very optimistic about your technology and enthusiastic about it causes you to have blinders on when it comes to risk assessment.

The FDA eventually clarified its results, insisting that the study was meant only to publicize the presence of the plasmid, not to suggest the bacterial DNA was necessarily dangerous. Nonetheless, the damage was done. As a result of the blunder,a plan was quashed forRecombinetics to raise an experimental herd in Brazil.

Sometimes being very optimistic about your technology and enthusiastic about it causes you to have blinders on when it comes to risk assessment.

Backlash to the FDA study exposed a fundamental disagreement between the agency and livestock biotechnologists. Scientists like Van Eenennaam, who in 2017 received a $500,000 grant from the Department of Agriculture to study Buris progeny, disagree with the FDAs strict regulatory approach to gene-edited animals. Typical GMOs are transgenic, meaning they have genes from multiple different species, but modern gene-editing techniques allow scientists to stay roughly within the confines of conventional breeding, adding and removing traits that naturally occur within the species. That said, gene editing is not yet free from errors and sometimes intended changes result in unintended alterations, notes Heather Lombardi, division director of animal bioengineering and cellular therapies at the FDAs Center for Veterinary Medicine. For that reason, the FDA remains cautious.

Theres a lot out there that I think is still unknown in terms of unintended consequences associated with using genome-editing technology, says Lombardi. Were just trying to get an understanding of what the potential impact is, if any, on safety.

Bhanu Telugu, an animal scientist at the University of Maryland and president and chief science officer at the agriculture technology startup RenOVAte Biosciences, worries that biotech companies will migrate their experiments to countries with looser regulatory environments. Perhaps more pressingly, he says strict regulation requiring long and expensive approval processes may incentivize these companies to work only on traits that are most profitable, rather than those that may have the greatest benefit for livestock and society, such as animal well-being and the environment.

What company would be willing to spend $20 million on potentially alleviating heat stress at this point? he asks.

On a windy winter afternoon, Raluca Mateescu leaned against a fence post at the University of Floridas Beef Teaching Unit while a Brahman heifer sniffed inquisitively at the air and reached out its tongue in search of unseen food. Since 2017, Mateescu, an animal geneticist at the university, has been part of a team studying heat and humidity tolerance in breeds like Brahman and Brangus (a mix between Brahman and Angus cattle). Her aim is to identify the genetic markers that contribute to a breeds climate resilience, markers that might lead to more precise breeding and gene-editing practices.

In the South, Mateescu says, heat and humidity are a major problem. That poses a stress to the animals because theyre selected for intense production to produce milk or grow fast and produce a lot of muscle and fat.

Like Nelore cattle in South America, Brahman are well-suited for tropical and subtropical climates, but their high tolerance for heat and humidity comes at the cost of lower meat quality than other breeds. Mateescu and her team have examined skin biopsies and found that relatively large sweat glands allow Brahman to better regulate their internal body temperature. With funding from the USDAs National Institute of Food and Agriculture, the researchers now plan to identify specific genetic markers that correlate with tolerance to tropical conditions.

If were selecting for animals that produce more without having a way to cool off, were going to run into trouble, she says.

A Brahman cow at the University of Floridas Beef Teaching Unit. Visual: Dyllan Furness

There are other avenues in biotechnology beyond gene editing that may help reduce the cattle industrys footprint. Although still early in their development, lab-cultured meats may someday undermine todays beef producers by offering consumers an affordable alternative to the conventionally grown product, without the animal welfare and environmental concerns that arise from eating beef harvested from a carcass.

Other biotech techniques hope to improve the beef industry without displacing it. In Switzerland, scientists at a startup called Mootral are experimenting with a garlic-based food supplement designed to alter the bovine digestive makeup to reduce the amount of methane they emit. Studies have shown the product to reduce methane emissions by about 20 percent in meat cattle, according to The New York Times.

In order to adhere to the Paris climate agreement, Mootrals owner, Thomas Hafner, believes demand will grow as governments require methane reductions from their livestock producers. We are working from the assumption that down the line every cow will be regulated to be on a methane reducer, he told The New York Times.

Meanwhile, a farm science research institute in New Zealand, AgResearch, hopes to target methane production at its source by eliminating methanogens, the microbes thought to be responsible for producing the greenhouse gas in ruminants. The AgResearch team is attempting to develop a vaccine to alter the cattle guts microbial composition, according to the BBC.

Genomic testing may also allow cattle producers to see what genes calves carry before theyre born, according to Mateescu, enabling producers to make smarter breeding decisions and select for the most desirable traits, whether it be heat tolerance, disease resistance, or carcass weight.

Despite all these efforts, questions remain as to whether biotech can ever dramatically reduce the industrys emissions or afford humane treatment to captive animals in resource-intensive operations. To many of the industrys critics, including environmental and animal rights activists, the very nature of the practice of rearing livestock for human consumption erodes the noble goal of sustainable food production. Rather than revamp the industry, these critics suggest alternatives such as meat-free diets to fulfill our need for protein. Indeed, data suggests many young consumers are already incorporating plant-based meats into their meals.

Ultimately, though, climate change may be the most pressing issue facing the cattle industry, according to Telugu of the University of Maryland, which received a grant from the Bill and Melinda Gates Foundation to improve productivity and adaptability in African cattle. We cannot breed our way out of this, he says.

Dyllan Furness is a Florida-based science and technology journalist. His work has appeared in Quartz, OneZero, and PBS, among other outlets.

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Biotechnology Could Change the Cattle Industry. Will it Succeed? - Undark Magazine

OpEd: Mayor Needs to Focus on the Real Needs of Our Community says Mike Molina – Maui Time

In a press release dated August 5, 2020, Mayor Victorino responded to the transmission of a proposed resolution I sent to the Governance, Ethics, and Transparency Committee that would seek a settlement to the Hawaii Wildlife Fund, ET AL, v. County of Maui.

The Mayor noted that my actions are highly irresponsible and I am using the Platform to garner votes. I believe the Mayors comments are an over reaction and ill advised. The transmission of the resolution for settlement has no impact on mediation and was not submitted with the intention to interfere with on-going negotiations.

I support continued mediation to resolve this matter once and for all. The proposed resolution for settlement I transmitted will be available to the Council if mediation fails. Its important to recognize that if the past is any indication for how the county fairs in this litigation matter, settlement or negotiations, the county has been on the short end of the stick.

Over the last 8 years, numerous courts have rejected the Countys defense; past settlements have resulted in an additional 5 years of litigation at a cost of over $4 million dollars to county taxpayers in legal fees. Based on past history, Im not holding a lot of faith that mediation will be constructive, however, I am hopeful.

Relative to the Mayors comments that my actions are highly irresponsible and a platform to garner votes, these comments are mean spirited and seek to drive a wedge in collaborative government. Dragging the injection well case over 8 years costing county residents over $4 million dollars is highly irresponsible.

As far as using the platform to garner votes, I am Chair of the Governance, Ethics, and Transparency Committee, it is my job as the Committee Chair, to address settlements and litigation of the County of Maui. Am I using this platform to garner votes, NO, Im using this platform to do my job as assigned to me by the County Council.

My intention in transmitting the proposed resolution for settlement is to provide the Council with an option to end an 8-year nightmare. My focus is to preserve the environment for our future families; reduce impacts to our reef systems, maintain marine life and lessen the dependency on the use of injection wells.

Over the past few months, the county has been hit with a pandemic, the likes of which we have not seen in decades. People are sick, businesses are closing, residents have lost their jobs and people cannot afford to pay rent or mortgages. Our priorities should be to help address these concerns, not spending hundreds of thousands of dollars on attorneys fees.

During these past months, the Mayor has focused his energies on attacking the Council on charter amendments, legislative initiatives and this litigation matter. With all due respect Mr. Mayor, your priorities are wrong. Your focus should be on providing shelter, economic recovery and the health and safety of our community. You are no longer a Councilmember, you are the Mayor, your job is to administer and now is the time to show some leadership.

In May, the Mayor asked for recommendations on how to spend federal assistance for COVID-19. The Council provided excellent recommendations for assistance to our community, however, it took over 3 months for the Mayor to act on the recommendations.

Mr. Mayor, please stop the constant attacking, stop the anger, stop the talk, show some leadership and focus on the real needs of our community.

Mike Molinaholds the County Council seat for the Makawao-Haik-Pia residency area.

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OpEd: Mayor Needs to Focus on the Real Needs of Our Community says Mike Molina - Maui Time

In Depth Analysis and Survey of COVID-19 Pandemic Impact on Global Canine Stem Cell Therapy Coronavirus Impact Editon of Key Players VETSTEM…

Rising number of corona virus cases has impacted numerous lives and led to numerous fatalities, and has affected the overall economic structure globally. The Canine Stem Cell Therapy has analyzed and published the latest report on the global Canine Stem Cell Therapy market. Change in the market has affected the global platform. Along with the Canine Stem Cell Therapy market, numerous other markets are also facing similar situations. This has led to the downfall of numerous businesses, because of the widespread increase of the number of cases across the globe.href=mailto:nicolas.shaw@cognitivemarketresearch.com>nicolas.shaw@cognitivemarketresearch.com or call us on +1-312-376-8303.

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In Depth Analysis and Survey of COVID-19 Pandemic Impact on Global Canine Stem Cell Therapy Coronavirus Impact Editon of Key Players VETSTEM...

Check up: Maybe next week will be better? – Stockhead

Heres our fortnightly wrap of all the news driving ASX health stocks.

Of the ASXs 133-odd small cap health stocks and of those which were trading on Wednesday, 58 were in positive territory over the last fortnight, eight were flat and 67 saw their share prices fall.

No matter which way you cut it, the last fortnight wasnt great for markets. The Small Ords was down almost 1 per cent and the broader market was in a similar state.

Another great rotation, as pundits have taken to calling the big sector sell downs and buy-ins, did not favour health this time with Biotech Dailys Top 40 index falling 2.4 per cent when compared to an ASX200 half percentage point lift in July.

However, fortune favours the bold and investors in Aroa Biosurgery (ASX:ARX) would be pleased with their first fortnight on the market, with the stock up 97 per cent from its IPO on July 24.

Aroa is treading a now familiar path with a wound care product that combines a matrix on which cells can regrow with a treatment for diabetic foot ulcers and venous leg ulcers.

The company is following in the footsteps of Avita (ASX:AVH) and Polynovo (ASX:PNV) which are both successfully treading hospital wards around the world.

Having already put its product through clinical trials and attained US Federal Drug Administration (FDA) approval, it has avoided following the other path trodden by Factor Therapeutics (ASX:FTT), which was trying to cure the same conditions and failed badly.

However Factor is up on the list as well because its board has finally found something to buy: Brain Biosciences, a commercial-stage veterinary medical technology company in the US which is trading as LONGMILE Veterinary PET Imaging.

Chair Dr Cherrell Hirst, who led the long search for the new face of Factor, will retire at the upcoming AGM and be replaced by Dr David Brookes, a rural medicine expert and ASX biotech director.

The deal is still non-binding and subject to due diligence, but this is the first one the Factor board has felt strongly enough about to release publicly.

Its subject to demonstrating to LONGMILE shareholders that Factor has at least $3m in cash when the deal is done and sorting out the board composition, among other things.

Health software company Oneview Healthcare (ASX:ONE) rose after saying installed live devices by the end of June were up 30 per cent on a year ago, and the June quarter saw two customers renew and one extend a contract.

Suda Pharmaceutical (ASX:SUD) finally had its day, after the Therapeutic Goods Administration (TGA) approved several months earlier than unexpected its insomnia mouth spray ZolpiMist.

Suda has been working on ZolpiMist since January 2015 when it licensed zolpidem from Amherst Pharma.

Stem cell play Regeneus (ASX:RGS) has also begun generating some interest among analysts and investors.

It recently updated its negotiating status with Japanese company Kyocera for the osteoarthritis treatment Progenza.

Under the terms of an MOU signed in March, Kyocera has exclusive rights to negotiate a commercial licence for Progenza in Japan. It was supposed to end in July but with talks moving ahead well, they agreed to extend the exclusivity period to the end of August.

And Cogstate (ASX:CGS) moved further ahead with its partnership with Eisai in Japan, which has begun building the brain performance application Easiit, a base element of a digital platform for dementia, that will incorporate Cogstates NouKNOW assessment by the end of September.

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Wound Care Biologics Market By Covid-19 Impact Analysis, Size, Regional Growth, Major Key Players, Technology And Industry Trends Till 2025 – eRealty…

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Exosome therapeutic market is expected to gain market growth in the forecast period of 2019 to 2026. Data Bridge Market Research analyses that the market is growing with a CAGR of 21.9% in the forecast period of 2019 to 2026 and expected to reach USD 31,691.52 million by 2026 from USD 6,500.00 million in 2018. Increasing prevalence of lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative diseases are the factors for the market growth.

Increased number of exosome therapeutics as compared to the past few years will accelerate the market growth. Companies are receiving funding for exosome therapeutic research and clinical trials. For instance, In September 2018, EXOCOBIO has raised USD 27 million in its series B funding. The company has raised USD 46 million as series a funding in April 2017. The series B funding will help the company to set up GMP-compliant exosome industrial facilities to enhance production of exosomes to commercialize in cosmetics and pharmaceutical industry.

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Exosomes are used to transfer RNA, DNA, and proteins to other cells in the body by making alteration in the function of the target cells. Increasing research activities in exosome therapeutic is augmenting the market growth as demand for exosome therapeutic has increased among healthcare professionals.

Increasing demand for anti-aging therapies will also drive the market. Unmet medical needs such as very few therapeutic are approved by the regulatory authority for the treatment in comparison to the demand in global exosome therapeutics market will hamper the market growth market. Availability of various exosome isolation and purification techniques is further creates new opportunities for exosome therapeutics as they will help company in isolation and purification of exosomes from dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, and urine and from others sources. Such policies support exosome therapeutic market growth in the forecast period to 2019-2026.

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Based on source, the market is segmented into dendritic cells, mesenchymal stem cells, blood, milk, body fluids, saliva, urine and others. Mesenchymal stem cells are dominating in the market because mesenchymal stem cells (MSCs) are self-renewable, multipotent, easily manageable and customarily stretchy in vitro with exceptional genomic stability. Mesenchymal stem cells have a high capacity for genetic manipulation in vitro and also have good potential to produce. It is widely used in treatment of inflammatory and degenerative disease offspring cells encompassing the transgene after transplantation.

Based on transporting capacity, the market is segmented into bio macromolecules and small molecules. Bio macromolecules are dominating in the market because bio macromolecules transmit particular biomolecular information and are basically investigated for their delicate properties such as biomarker source and delivery system.

The exosome therapeutic market, by end user, is segmented into hospitals, diagnostic centers and research & academic institutes. Hospitals are dominating in the market because hospitals provide better treatment facilities and skilled staff as well as treatment available at affordable cost in government hospitals.

The major players covered in the report are evox THERAPEUTICS, EXOCOBIO, Exopharm, AEGLE Therapeutics, United Therapeutics Corporation, Codiak BioSciences, Jazz Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH, ReNeuron Group plc, Capricor Therapeutics, Avalon Globocare Corp., CREATIVE MEDICAL TECHNOLOGY HOLDINGS INC., Stem Cells Group among other players domestic and global. Exosome therapeutic market share data is available for Global, North America, Europe, Asia-Pacific, and Latin America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

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