The procedure is carried out in one day as an outpatient, and patients do not need an overnight stay with us.

We need some blood tests and a urine test for anesthetic safety. Once we are happy with these, we administer a short general anesthetic. Typically this lasts 30 to 90 minutes.

We need to have x-rays of the affected areas and also a chest x-ray. Where recent x-rays are available from your own Vet, we will not need to repeat these.

We then harvest approximately 40 grams of fat from a site behind the shoulder or just inside the tummy and your pet is woken from the anesthetic. There will be a few stitches that need to come out in 10 days.

A small blood sample is taken and prepared into a platelet rich plasma (PRP) solution. The fat is processed to isolate, concentrate and activate stem cells in our lab, and this takes around 4 hours. The stem cells are mixed with the PRP in preparation for injection. Once we have the stem cells, we administer a light sedative to allow us to inject the cells directly into the affected areas. A portion of the cells are given intravenously.

Well then book you follow up consultations at 30, 60 and 90 days.

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Stem Cell Vet UK Treat Arthritis in Dogs & Cats

If you live in Eagle, Boise, or the surrounding areas, then you have picked the perfect place for family pet's veterinary care. Getting pets well and having them stay well is very important to us and we will take every step to give your pet the best possible care. Simply put, our mission - We care for pets and people too! We put the needs of our clients and patients first; continually striving for service excellence. We are a team of veterinary professionals working together to deliver exceptional veterinary care with empathy, compassion, and understanding.

We understand the special role your pet plays in your family and we are dedicated to becoming your partner in your pets health care. We treat your pet as we would our own. Our job is not only to treat your pet when he or she isnt feeling well, but also to help you learn how to keep your best friend happy and healthy. Our entire veterinary health care team is committed to providing personal attention to the unique concerns of each individual pet owner as well as to the needs of individual pets.

All Pet Complex is a full service animal hospital specializing in minimally invasive surgery such as laparoscopic spay, advanced orthopedic procedures, non-surgical neutering (Zeuter), and comprehensive dentistry. We maintain a full-scale health program for your pet that includes annual physical exams, vaccinations, neutering and spaying, nutritional counseling, microchipping, and parasite control. Our veterinarians, Dr. Stoenner and Dr. Goodwin, have more than 50 years of combined experience in all types of conditions and treatments, and receive ongoing and extensive training to ensure service excellence. They are supported by a staff of caring, highly skilled certified veterinary technicians and office staff who truly understand the human-animal bond and will always treat your pet with tender loving care.

At All Pet Complex Veterinary Hospital we strive to be leaders and innovators in our approach to veterinary care by offering state-of-the-art services such as stem cell therapy and therapeutic laser treatments to minimize or reduce your pet's pain and promote healing. Beyond first rate pet care, we make our clinic comfortable, friendly, and clean! At All Pet Complex you are always welcome to schedule a tour, or simply click here to see a video of our hospital!

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All Pet Complex | Eagle Veterinarian Hospital

Stem cell facts

What are stem cells?

Stem cells are cells that have the potential to develop into many different or specialized cell types. Stem cells can be thought of as primitive, "unspecialized" cells that are able to divide and become specialized cells of the body such as liver cells, muscle cells, blood cells, and other cells with specific functions. Stem cells are referred to as "undifferentiated" cells because they have not yet committed to a developmental path that will form a specific tissue or organ. The process of changing into a specific cell type is known as differentiation. In some areas of the body, stem cells divide regularly to renew and repair the existing tissue. The bone marrow and gastrointestinal tract are examples of areas in which stem cells function to renew and repair tissue.

The best and most readily understood example of a stem cell in humans is that of the fertilized egg, or zygote. A zygote is a single cell that is formed by the union of a sperm and ovum. The sperm and the ovum each carry half of the genetic material required to form a new individual. Once that single cell or zygote starts dividing, it is known as an embryo. One cell becomes two, two become four, four become eight, eight become sixteen, and so on, doubling rapidly until it ultimately grows into an entire sophisticated organism composed of many different kinds of specialized cells. That organism, a person, is an immensely complicated structure consisting of many, many, billions of cells with functions as diverse as those of your eyes, your heart, your immune system, the color of your skin, your brain, etc. All of the specialized cells that make up these body systems are descendants of the original zygote, a stem cell with the potential to ultimately develop into all kinds of body cells. The cells of a zygote are totipotent, meaning that they have the capacity to develop into any type of cell in the body.

The process by which stem cells commit to become differentiated, or specialized, cells is complex and involves the regulation of gene expression. Research is ongoing to further understand the molecular events and controls necessary for stem cells to become specialized cell types.

Stem Cells:One of the human body's master cells, with the ability to grow into any one of the body's more than 200 cell types.

All stem cells are unspecialized (undifferentiated) cells that are characteristically of the same family type (lineage). They retain the ability to divide throughout life and give rise to cells that can become highly specialized and take the place of cells that die or are lost.

Stem cells contribute to the body's ability to renew and repair its tissues. Unlike mature cells, which are permanently committed to their fate, stem cells can both renew themselves as well as create new cells of whatever tissue they belong to (and other tissues).

Why are stem cells important?

Stem cells represent an exciting area in medicine because of their potential to regenerate and repair damaged tissue. Some current therapies, such as bone marrow transplantation, already make use of stem cells and their potential for regeneration of damaged tissues. Other therapies that are under investigation involve transplanting stem cells into a damaged body part and directing them to grow and differentiate into healthy tissue.

Embryonic stem cells

During the early stages of embryonic development the cells remain relatively undifferentiated (immature) and appear to possess the ability to become, or differentiate, into almost any tissue within the body. For example, cells taken from one section of an embryo that might have become part of the eye can be transferred into another section of the embryo and could develop into blood, muscle, nerve, or liver cells.

Cells in the early embryonic stage are totipotent (see above) and can differentiate to become any type of body cell. After about seven days, the zygote forms a structure known as a blastocyst, which contains a mass of cells that eventually become the fetus, as well as trophoblastic tissue that eventually becomes the placenta. If cells are taken from the blastocyst at this stage, they are known as pluripotent, meaning that they have the capacity to become many different types of human cells. Cells at this stage are often referred to as blastocyst embryonic stem cells. When any type of embryonic stem cells is grown in culture in the laboratory, they can divide and grow indefinitely. These cells are then known as embryonic stem cell lines.

Fetal stem cells

The embryo is referred to as a fetus after the eighth week of development. The fetus contains stem cells that are pluripotent and eventually develop into the different body tissues in the fetus.

Adult stem cells

Adult stem cells are present in all humans in small numbers. The adult stem cell is one of the class of cells that we have been able to manipulate quite effectively in the bone marrow transplant arena over the past 30 years. These are stem cells that are largely tissue-specific in their location. Rather than typically giving rise to all of the cells of the body, these cells are capable of giving rise only to a few types of cells that develop into a specific tissue or organ. They are therefore known as multipotent stem cells. Adult stem cells are sometimes referred to as somatic stem cells.

The best characterized example of an adult stem cell is the blood stem cell (the hematopoietic stem cell). When we refer to a bone marrow transplant, a stem cell transplant, or a blood transplant, the cell being transplanted is the hematopoietic stem cell, or blood stem cell. This cell is a very rare cell that is found primarily within the bone marrow of the adult.

One of the exciting discoveries of the last years has been the overturning of a long-held scientific belief that an adult stem cell was a completely committed stem cell. It was previously believed that a hematopoietic, or blood-forming stem cell, could only create other blood cells and could never become another type of stem cell. There is now evidence that some of these apparently committed adult stem cells are able to change direction to become a stem cell in a different organ. For example, there are some models of bone marrow transplantation in rats with damaged livers in which the liver partially re-grows with cells that are derived from transplanted bone marrow. Similar studies can be done showing that many different cell types can be derived from each other. It appears that heart cells can be grown from bone marrow stem cells, that bone marrow cells can be grown from stem cells derived from muscle, and that brain stem cells can turn into many types of cells.

Peripheral blood stem cells

Most blood stem cells are present in the bone marrow, but a few are present in the bloodstream. This means that these so-called peripheral blood stem cells (PBSCs) can be isolated from a drawn blood sample. The blood stem cell is capable of giving rise to a very large number of very different cells that make up the blood and immune system, including red blood cells, platelets, granulocytes, and lymphocytes.

All of these very different cells with very different functions are derived from a common, ancestral, committed blood-forming (hematopoietic), stem cell.

Umbilical cord stem cells

Blood from the umbilical cord contains some stem cells that are genetically identical to the newborn. Like adult stem cells, these are multipotent stem cells that are able to differentiate into certain, but not all, cell types. For this reason, umbilical cord blood is often banked, or stored, for possible future use should the individual require stem cell therapy.

Induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) were first created from human cells in 2007. These are adult cells that have been genetically converted to an embryonic stem celllike state. In animal studies, iPSCs have been shown to possess characteristics of pluripotent stem cells. Human iPSCs can differentiate and become multiple different fetal cell types. iPSCs are valuable aids in the study of disease development and drug treatment, and they may have future uses in transplantation medicine. Further research is needed regarding the development and use of these cells.

Why is there controversy surrounding the use of stem cells?

Embryonic stem cells and embryonic stem cell lines have received much public attention concerning the ethics of their use or non-use. Clearly, there is hope that a large number of treatment advances could occur as a result of growing and differentiating these embryonic stem cells in the laboratory. It is equally clear that each embryonic stem cell line has been derived from a human embryo created through in-vitro fertilization (IVF) or through cloning technologies, with all the attendant ethical, religious, and philosophical problems, depending upon one's perspective.

What are some stem cell therapies that are currently available?

Routine use of stem cells in therapy has been limited to blood-forming stem cells (hematopoietic stem cells) derived from bone marrow, peripheral blood, or umbilical cord blood. Bone marrow transplantation is the most familiar form of stem cell therapy and the only instance of stem cell therapy in common use. It is used to treat cancers of the blood cells (leukemias) and other disorders of the blood and bone marrow.

In bone marrow transplantation, the patient's existing white blood cells and bone marrow are destroyed using chemotherapy and radiation therapy. Then, a sample of bone marrow (containing stem cells) from a healthy, immunologically matched donor is injected into the patient. The transplanted stem cells populate the recipient's bone marrow and begin producing new, healthy blood cells.

Umbilical cord blood stem cells and peripheral blood stem cells can also be used instead of bone marrow samples to repopulate the bone marrow in the process of bone marrow transplantation.

In 2009, the California-based company Geron received clearance from the U. S. Food and Drug Administration (FDA) to begin the first human clinical trial of cells derived from human embryonic stem cells in the treatment of patients with acute spinal cord injury.

What are experimental treatments using stem cells and possible future directions for stem cell therapy?

Stem cell therapy is an exciting and active field of biomedical research. Scientists and physicians are investigating the use of stem cells in therapies to treat a wide variety of diseases and injuries. For a stem cell therapy to be successful, a number of factors must be considered. The appropriate type of stem cell must be chosen, and the stem cells must be matched to the recipient so that they are not destroyed by the recipient's immune system. It is also critical to develop a system for effective delivery of the stem cells to the desired location in the body. Finally, devising methods to "switch on" and control the differentiation of stem cells and ensure that they develop into the desired tissue type is critical for the success of any stem cell therapy.

Researchers are currently examining the use of stem cells to regenerate damaged or diseased tissue in many conditions, including those listed below.

References

REFERENCE:

"Stem Cell Information." National Institutes of Health.

Excerpt from:
What Are Stem Cells? Research, Transplant, Therapy, Definition

Stem Cell Therapy significantly help pets with osteoarthritis and some liver and joint problems! This therapy uses your pets own, adult stem cells from its own fat and there is no chance of rejection as there is with organ replacement. Vet Stem is the only veterinary stem cell therapy company that is backed by peer reviewed, approved, non biased studies for therapeutic use in animals. Vet Stem is also has banking service, whereby cells can be harvested during routine procedures, on younger animals, before the need arises and avoids additional anesthetic procedures when the pet is older. Dr. MacPhail and Dr Ulbrich have both been certified with Vet Stem to perform these procedures since January of 2010.

DeLand veterinarian works to help ailing animals with stem cells

By SKYLER SWISHER, Staff Writer April 16, 2012 1:05 AM

Dr. Tom MacPhail holds a syringe of Lucys stem cells that are ready for injection at the DeLand Animal Hospital, in DeLand recently. (N-J | Peter Bauer)

Lucy, a 10-year-old pug being held by Dennis Stasinski, is injected with her own stem cells during treatment by Dr. Tom MacPhail at the DeLand Animal Hospital in DeLand recently. (N-J | Peter Bauer)

DELAND Lucy the 10-year-old pug tried to lift her legs off the grass, but they just dragged behind her motionless.

Her tongue lolled out of her mouth, and her eyes beamed. But her tail didnt wag.

Lucy is partly paralyzed, and her condition is worsening by the day. In the past, she would have faced euthanasia.

But even with her gloomy prognosis, her owner Dr. Thomas MacPhail hasnt given up. He hopes stem-cell treatment, a procedure that uses an animals own cells to spark healing, will help repair nerves in Lucys back. If that happens, she could gain more control over her bowels and rear legs.

Its a shot in the dark, but it will give her a chance, said MacPhail, who owns DeLand Animal Hospital.

MacPhail has treated about 20 dogs with stem cells at his clinic over the past two years. DeLand Animal Hospital is one of only a few clinics in the area that offer the treatment.

A banner on the buildings side advertises the procedure to motorists passing on U.S. 92.

Stem-cell treatment for humans has been a controversial topic, but for the past decade, veterinarians have been using it on animals. Vets extract an animals own adult stem cells and inject them. The type of stem cells used differs from the embryonic stem cells that spurred an ethics debate.

The procedure was first used to treat tendon and ligament injuries in horses. A few years ago, vets started using stem cells to treat arthritis in dogs and the occasional cat.

Lucys case is taking the procedure into less-tested waters.

She was born unable to walk because of a condition known as swimmers pup, which damaged her joints. The breeder turned Lucy over to MacPhail in hopes that he could save her. Two days after Lucy was signed over, she started walking. For the past two years, though, a spinal condition has left her struggling to walk.

Research conducted by veterinarians could eventually pave the way for similar types of stem-cell treatments to be used on humans, said Gregory L. Ferraro, director of the University of California, Davis Center for Equine Health.

At UC Davis, researchers in the veterinary and medical schools are working together to advance stem-cell therapy. One day, stem cells could be used to repair a severed Achilles tendon, slow kidney failure and alleviate spinal-cord issues similar to Lucys.

Research has demonstrated stem cells are effective in treating arthritis in animals, but the procedure is still new and unrefined, said Ferraro, who has worked in veterinarian science for 40 years.

We need to do more work, he said. We dont know what the perfect dose is and what the perfect re-treatment time is.

One thing is certain. Stem-cell treatment is expensive.

MacPhail said the procedure costs about $2,000. Typically, it provides relief for six to 48 months, he said.

The treatment begins when vets remove stem-cell-rich fat from a dogs abdomen. The fat is sent to a laboratory in California operated by San Diego-based Vet-Stem, which has treated more than 8,000 horses, dogs and cats since it was founded in 2002.

At the laboratory, stem cells are extracted from the fat. A stem-cell injection is sent back to the vet office, which is then administered in the animals arthritic joints.

The cells work by reducing inflammation and sparking the bodys healing process, MacPhail said.

Testimonials supplied by Vet-Stem tout the treatment as life saving.

Lizbeth Grall, 50, of Alpharetta, Ga., said she watched her four-legged soul mate Apollos degenerative arthritis cause him so much discomfort he couldnt get up. She turned to stem cell therapy in hopes that it would extend the 3-year-old bullmastiffs life span. She spent $3,500 on the initial treatment and $1,500 on follow-up IV treatments.

It was like black and white, Grall said. He went from the intensive-care unit in the hospital to out on the ball field.

MacPhail hopes he will soon be able to share a similar story about Lucy.

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Veterinary Stem Cell Therapy - DeLand, FL DeLand Animal ...

Applying regenerative cells from your pets own healthy tissue directly to the site of an injury helps the body heal itself by secreting growth factors, reducing inflammation, modulating the immune system and regenerating injured tissue in a potent but natural way. This holistic process can be used in addition to or as an alternative to chronic drug therapy or surgery saving 1000s of dollars over your pets life.

Fat tissue is obtained from your pet in an in-clinic procedure, and regenerative cells (including stem cells) are prepared for re-injection in about 90 minutes. Initial results may be evident as early as the 1st week.

Regenerative cells promote healing and regeneration of injured or damaged tissue. Stem cells are regenerative cells that can differentiate into multiple cell types to form new functional tissue. These cells, located in your pets fat stores can be harvested, separated from the fat and stimulated to revert to an active reparative state. Regenerative cells may also secrete factors that reduce autoimmune responses and inflammation, promote cell survival, and stimulate tissue regeneration.

Our system providers, InGeneron and Medivet Biologics, have been conducting research for years on the use of autologous adult stem cells in regenerative medicine. InGenerons team of scientists and clinicians have published more than 40 peer-reviewed studies in collaboration with renowned academic facilities such as M.D. Anderson Cancer Center and Tulane University. Medivet is currently conducting research on stem cell therapy for osteoarthritis at Kansas State University, and Cartilage Regeneration and osteoarthritis at the University of Georgia.

Unlike other cell therapy procedures, both the InGeneron and MediVet systems enable isolation and treatment within the same day processed at the Safari Stem Cell Laboratory assuring high quality and quantity of cells.

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Pet Stem Cell Therapy | Safari Veterinary Care Centers in ...

Jeff Hays is a filmmaker and a serial entrepreneur. He began making films back in the late nineties. Hes best known for Fahrenhype 9/11 (2004), a response to Michael Moores Fahrenheit 9/11, and On Native Soil (2006), a documentary focusing on the passionate demand of the surviving family members of 9/11 victims for an official investigation into the 9/11 attacks. This documentary, which was narrated by Kevin Costner and Hillary Swank was short-listed for an Academy Award in 2005.

Hays recent health documentary releases are Bought, Doctored, Undoctored, Rigged 2016 and the GMOs Revealed and Vaccines Revealed series programs. Hays explains, In recent years my eyes have been opened to alternative healthcare options. The immediate increase in health I experienced personally after starting down this road is something Ive just got to share with people.

Hays most recent release is Christ Revealed, a 9-episode docuseries featuring exclusive expert interviews and a stunning tour of Israel.

Also, Chasing the Scream, the New York Times Best Selling book by Johann Hari is being brought to life by Jeff Hays Films and is now in pre-production with Academy Award winning co-producers and Academy Award nominated directors attached.

Two additional documentary series from Jeff Hays Films are being released in early 2018. The Healing Miracle: the truth about stem cells, and The Real Skinny on Fat, the truth about weight loss.

A pet project is Movie Maker Academy where Hays is on the faculty teaching filmmakers and entrepreneurs how to create successful donor crowdfunding projects based on his 7-figure success in crowdfunding.

Hays lives in the mountains of Utah with his dog Abby and works from his office in NY. Hes the father of 9, and grandfather of 12, with new ones annually

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Stem Cell Docu Series

Home / ServicesStem Cell Therapy Exam and Evaluation for Stem Cell Therapy

Examination

Physical Examination, Consultation for appropriateness of stem cell therapy

80

Radiographs

To determine if there is any evidence of cancer as this is a contraindication for stem cell therapy

250

Blood Tests

To determine internal organ function & tolerance of anesthesia. Also, pets that have infections are not candidates for stem cell therapy.

150

Mri

Pets that have spinal or neurological disease that stem cell therapy is being considered require this imaging to determine the location of the lesion.

1500

Surgical Fat Harvest

General anesthesia & a small incision over the upper abdomen to remove a golf ball size amount of abdominal fat.

300

Stem Cell Preparation

Enzymatic Separation of Stem Cells from the fat. Concentration of the stem cells for injection

1500

Platelet Rich Plasma

Blood is collected from your pet & used to concentrate the blood platelets. This "Platelet Rich Plasma" (PRP) is sometimes used alone to stimulate regeneration. PRP may also be used w/ the stem cells to activate & support stem cell function in certain conditions. PRP is used in most cases of regenerative therapy.

250

Sedation for Administration

Some procedures such as intra-articular injection may require sedation

100

I.V. Administration of Stem Cells

Infusion of a preparation of stem cells into your pets blood stream

350

Joint Injection of Stem Cells

Intra-articular injection of cells into the joint space. Price is per joint.

150

Ultrasound Guidance

Some injections require ultrasound to guide the needle into the appropriate tissue

250

Each case is evaluated to determine if Regenerative Therapy is appropriate. A prognosis for therapy will be discussed as well as the likelihood of the need for additional treatment. Stem cell therapy can repair damaged tissues but it may not change the conditions that caused the damage in the first place so repeat therapy may be necessary. This repeat therapy will require additional stem cells from stored cells or from additional surgical collection procedures.

Account Set up

One time fee per family of pets

150

Yearly Storage Fee (waived for first year)

Cells are stored in Liquid Nitrogen Vapor

150

Retrieval Fee

This fee is per aliquot of cells

75

Culturing Fee

Expansion of cells to achieve a therapeutically effective number of Cells

150

Once cells are frozen one time they cannot be re-frozen. For this reason the sample is stored in several (2-4) separate tubes (aliquots). Depending on your pets needs only the amount required will be retrieved so that future stores are still available.

Your veterinarian can use the Stem Cell Safari processing system. Your veterinarian does the diagnostic tests & consultation to determine if your pet is a candidate for stem cell therapy. Then your veterinarian collects a sample of your pets fatty tissue. We collect this tissue & process it returning it to your veterinarian promptly for application of the stem cells to the appropriate area in need of regenerative therapy.

Stem Cell Processing

90 minute process of separating stem cells from fatty tissue.

1000

Platelet Rick Plasma Kit

Allows your veterinarian to collect platelet rich plasma from your pet.

75

Hand Delivery

If local to the Houston Texas are we will provide pick up of adipose tissue & delivery of stem cells to your veterinarians practice

0

Shipping Charges

If your veterinarian is not local to the Houston area then overnight shipping charges are necessary to deliver processed stem cells to your veterinarian.

250

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Pet Stem Cell Therapy Services | Stem Cell Safari, League ...

As degenerative joint disease is a natural part of the aging process, preventing it is challenging, and these preventative measures can only be effective to a certain extent. Building and maintaining muscles, tendons and joints can be the most effective measure an owner can take. This entails regular exercise for the dog. The frequency, durations and intensity should be varied depending on the dog, but exercise will ensure the muscles and limbs are as healthy as possible for as long as possible. This measure also comes with the benefit of keeping owners fit and healthy. On top of regular exercise, massaging the dog, undertaking at-home strengthening exercises and water therapy may also help to prevent arthritis in the long term.

The next step for owners to take is to alter their dogs diet. Carbohydrates should be discouraged as they promote inflammation. Fresh foods that are unprocessed, are rich in unadulterated enzymes and can help to reduce inflammation. A healthy, balanced diet is key to the long-term health of the dogs muscles and joints.

Certain supplements can also be added to the dogs diet, to encourage muscle and joint retention and prevent degeneration. These are known as joint supportive agents, and common, effective agents are eggshell membrane, glucosamine sulfate with MSM, and cetyl myristoleate.

Both the exercise measures outlined above and the diet alterations may not prevent degeneration entirely, but they may well prevent it occurring until dogs are much older.

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Stem Cell Therapy in Dogs - Procedure, Efficacy, Recovery ...

Pulmonary hypertension, high pressure in the blood vessels of the lungs, is a common and serious complication of chronic lung diseases, including idiopathic pulmonary fibrosis (IPF).

IPF is a type of interstitial lung disease, which causes progressive scarring, leading to the lung tissue thickening and stiffening. In particular, it affects the interstitium, or the area between the alveoli where gas exchange takes place in the lungs, and the blood vessels. The scar tissue reduces lung capacity and restricts gas exchange, resulting in less oxygen being transferred to the blood.

The exact mechanismthrough which IPF can cause pulmonary hypertension is not well understood, but it is thought that the scarring restricts blood vessels, impeding blood flow and making it more difficult for the heart to pump blood through the lungs. Another theory is that the damage response and resulting scar tissue reactivates pathways involved in lung development and triggers vascular remodeling. This can change the shape of the blood vessels, such as causing them to narrow and restrict blood flow.

IPF is a debilitating and fatal condition, and while current therapies can help to improve survival and quality of life, there is no known cure. However, research into promising approaches like stem cell therapy is ongoing.

The body is made up of many different types of specialized cells that fulfill specific functions.

Once a cell is specialized, it generally cannot change and will only divide to produce similar cells. Stem cells are different in that they have the potential to develop and specialize into multiple different types of cells. Depending on where the stem cell originates, the type and range of cells it can develop into will differ.

By administering stem cells to IPF patients, it may be possible to generate the new lung tissue necessary for effective gas exchange.

Mesenchymal stem cells (MSCs) are now being investigated to treat IPF due to their ability to potentially reduce inflammation in the lungs. Damage caused by inflammation can lead to scarring in the lungs, so reducing lung inflammation may be able to lessen further scarring.

MSCs can be obtained from various tissues, including the adult bone marrow, umbilical cord blood, and the placenta.

Bothongoing and completed clinical trials have investigated stem cell therapy in IPF patients.

A proof-of-concept,open-label Phase 1 clinical trial (NCT01385644), carried out at The Prince Charles Hospital in Brisbane, Australia, aimed to determine whether MSC therapy was safe and feasible. The study enrolled eight IPF patients, who received either a high or low concentration of MSCs. Trial results, published in the journal Respirology, suggested that the therapy is feasible and both doses were well-tolerated, with only minor and short-term adverse effects. At six months after treatment, the patients showed no worsening in their condition.

A Phase 1 randomized and blinded, placebo-controlled clinical trial, called AETHER (NCT02013700), enrolled 25 IPF patients at the Interdisciplinary Stem Cell Institute at the University of Miami. The trial aimed to assess the safety of MSC therapy, and gain a preliminary idea of its efficacy over a 60-week period. Participants were randomly assigned a single dose of one of three concentrations of MSCs or to a placebo. The trial is ongoing, but no longer recruiting participants.

Results from nine patients, who were treated and monitored for the full 60 weeks, have been published in the scientific journal, Chest. These results did not include a placebo arm. The treatment appeared to be well-tolerated and no serious side effects due to the therapy were recorded. However two patients died for reasons attributed to disease progression.

The only study currently recruiting patients is a Phase 1/2 clinical trial (NCT02745184) taking place at two sites in China. Researchers intend to isolate lung stem cells from the patients own bronchi (the large tubes of the lungs) and expand them in the laboratory. About 20 enrolled patients will then receive a single injection of their cultured lung stem cells directly into the area affected by IPF.

To assess the safety of the treatment, patients will be monitored for side effects for up to one year. Efficacy will be measured by changes in several lung function and exercise ability tests. The primary test, at 48 weeks post-treatment, will be the change in forced vital capacity (FVC), or the volume of air that can be quickly exhaled after a deep breath. The trial is expected to finish in December 2018.

***

Pulmonary Hypertension Newsis strictly a news and information website about the disease. It does not provide medical advice, diagnosis ortreatment.This contentis not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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Stem Cell Therapy & Idiopathic Pulmonary Fibrosis

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